Positions
- Assistant Professor
-
Urology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- One Baylor Plaza, ALKT-N730 (Office)
-
Houston, TX 77030
United States
Phone: (713) 798-6266
Education
- Ph.D. from Baylor College Of Medicine
- 01/2005 - Houston, TX United States
- Post-Doctoral Fellowship at Baylor College Of Medicine
- 01/2010 - Houston, Texas United States
Honors & Awards
- Outstanding Abstract Award
- Endocrine Society (01/2012)
- Travel Award for American Society of Andrology
- National Institutes of Health (01/2011)
- Poster Merit Award
- American Society of Andrology (01/2011)
- Travel Scholar at the American Society for Reproductive Medicine
- Society of Male Reproductive Urology (01/2010)
- Travel Award for the American Society of Andrology
- National Institutes of Health (01/2010)
- Poster Merit Award
- American Society of Andrology (01/2010)
- Outstanding Abstract Award
- Endocrine Society (01/2005)
Professional Interests
- Urology Research
Professional Statement
Carolina J. Jorgez, Ph.D., specializes in the study of the genetics of male infertility and the causes of congenital and acquired pediatric urologic diseases ranging from common defects such as cryptorchidism and hypospadias to rare ones such as bladder exstrophy. By understanding etiology, she hopes to advance prospects for treatment. In order to understand the molecular mechanisms and phenotypic effects of genomic rearrangements in the development of the genitourinary tract, she uses different molecular techniques that allow one to identify and characterize the breakpoints of submicroscopic chromosome deletions and duplications, to infer mechanisms and to study patients to determine potential phenotypic consequences of copy-number variation and gene mutations. In addition, she is interested in learning how the function of the mitochondrion is important in the development of the genitourinary tract.Websites
VIICTR Research Database
Selected Publications
- Jorgez CJ, Weedin JW, Sahin A, Tannour-Louet M, Han S, Bournat JC, Mielnik A, Cheung SW, Nangia AK, Schlegel PN, Lipshultz LI, Lamb DJ "Aberrations in Pseudoautosomal Regions (PARs) Found in Infertile Men with Y-Chromosome Microdeletions.." J. Clin. Endocrinol. Metab.. 2011 Apr;96(4):E674-9. Pubmed PMID: 21252244
- Shen JJ, Huang L, Li L, Jorgez C, Matzuk MM, Brown CW "Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.." Mol. Endocrinol.. 2009 Jan;23(1):113-23. Pubmed PMID: 19008465
- Jorgez CJ, Dang DD, Wapner R, Farina A, Simpson JL, Bischoff FZ "Elevated levels of total (maternal and fetal) beta-globin DNA in maternal blood from first trimester pregnancies with trisomy 21.." Hum. Reprod.. 2007 Aug;22(8):2267-72. Pubmed PMID: 17584747
- Jorgez CJ, Lin YN, Matzuk MM "Genetic manipulations to study reproduction.." Mol. Cell. Endocrinol.. 2005 Apr 29;234(41276):127-35. Pubmed PMID: 15836961
- Jorgez CJ, Bischoff FZ "Improving enrichment of circulating fetal DNA for genetic testing: size fractionation followed by whole gene amplification.." Fetal. Diagn. Ther.. 2009;25(3):314-9. Pubmed PMID: 19776594
- Jorgez CJ, De Mayo FJ, Matzuk MM "Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal.." Genesis. 2006 Apr;44(4):183-8. Pubmed PMID: 16604527
- Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM "Intraovarian activins are required for female fertility.." Mol. Endocrinol.. 2007 Oct;21(10):2458-71. Pubmed PMID: 17609433
- Orozco AF, Jorgez CJ, Horne C, Marquez-Do DA, Chapman MR, Rodgers JR, Bischoff FZ, Lewis DE "Membrane protected apoptotic trophoblast microparticles contain nucleic acids: relevance to preeclampsia.." Am. J. Pathol.. 2008 Dec;173(6):1595-608. Pubmed PMID: 18974299
- Hwang K, Yatsenko AN, Jorgez CJ, Mukherjee S, Nalam RL, Matzuk MM, Lamb DJ "Mendelian genetics of male infertility.." Ann. N. Y. Acad. Sci.. 2010 Dec;1214(1):E1-E17. Pubmed PMID: 21382200
- Orozco AF, Jorgez CJ, Ramos-Perez WD, Popek EJ, Yu X, Kozinetz CA, Bischoff FZ, Lewis DE "Placental release of distinct DNA-associated micro-particles into maternal circulation: reflective of gestation time and preeclampsia.." Placenta. 2009 Oct;30(10):891-7. Pubmed PMID: 19692120
- Jorgez CJ, Dang DD, Simpson JL, Lewis DE, Bischoff FZ "Quantity versus quality: optimal methods for cell-free DNA isolation from plasma of pregnant women.." Genet. Med.. 2006 Oct;8(10):615-9. Pubmed PMID: 17079877
- Jorgez CJ, Simpson JL, Bischoff FZ "Recovery and amplification of placental RNA from dried maternal blood spots: utility for non-invasive prenatal diagnosis.." Reprod. Biomed. Online. 2006 Oct;13(4):558-61. Pubmed PMID: 17007679
- Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM "Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.." Mol. Cell. Biol.. 2008 Dec;28(23):7001-11. Pubmed PMID: 18809571
- Jorgez CJ, Bischoff FZ "Stability of placental RNA using dried maternal blood spots.." Reprod. Biomed. Online. 2008 Nov;17(5):716-21. Pubmed PMID: 18983758
Memberships
- American Society for Reproductive Medicine
- Member
- Society for the Study of Reproduction
- Member
- American Society for Human Genetics
- Member
- American Society for Andrology
- Member
- American Urological Association
- Member
- Endocrine Society
- Member
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