- Graduate Student
- Molecular Physiology & Biophysics
- Baylor College of Medicine
- Houston, TX, US
- BS from University of Nebraska - Lincoln
Honors & Awards
- People's Choice & First Prize (tie) BCM 3MT Competition
- Cover Art Competition Winner
- Best Student Oral Presentation
- "Hippo Pathway Regulation of Retinal Regeneration"
- 1st & 3rd Place Image Competition
- Poster Finalist
- "Hippo Pathway Regulation of Retinogenesis"
- Cellular and Molecular Mechanisms of Regeneration
- Müller Glia-mediated Retinal Regeneration
- *Rueda EM, *Hall BM, Hill MC, Swinton PG, Tong X, Martin JF, Poché RA. "The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming.." Cell Reports. 2019 May 7;27(6):16371649. Pubmed PMID: 31067451
- *Dustin D, *Hall BM, Annapragada A, Pautler RG. "Neuroimaging in Alzheimer's disease: preclinical challenges toward clinical efficacy.." Translational Research. 2016 March 12;175:37-53. Pubmed PMID: 27033146
- Hippo Pathway Regulation of Mammalian Müller Glia-mediated Regeneration
- Vision loss due to congenital retinal degeneration, aging, or traumatic injury remains a significant clinical burden. While retinal neuron loss is permanent in mammals, non-mammalian vertebrate retinae have an amazing ability to regenerate. To do so, glial cells in the retina called Müller glia (MG) proliferate and reprogram to a multi-potent state that can re-differentiate into new retinal neurons capable of vision restoration. Mammalian retinae also contain MGs and we aim to determine the reason why they are not also regenerative.
- The Hippo pathway has been shown to negatively regulate regeneration in the mammalian heart, liver, and small intestine. We hypothesized that the Hippo pathway may have a similar role in the retina by preventing MG regenerative reprogramming. To test this hypothesis, we first determined that Hippo signaling is active during retinal injury. Using genetic mouse models, we bypassed Hippo signaling in mouse MGs which were then able to proliferate – a critical first step in the regenerative process driven by Müller glia in regenerative species.
- My future work will determine whether the newly generated cells can become neurons to restore vision in blind mice.