Email

susanh@bcm.edu

Positions

Professor and L. F. McCollum Chair in Molecular Physiology

Integrative Physiology
Baylor College of Medicine
Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Education

Advanced Training from Columbia University College Of Physicians And Surgeons

01/1976 - New York, NY United States

Ph.D. from University Of Colorado School Of Medicine

01/1976 - Denver, CO United States

B.S. from Indiana University

01/1971 - Bloomington, IN United States

Professional Interests

• Biochemistry and Biophysics
• Cardiovascular Sciences
• Cell and Developmental Biology
• Human Disease

Professional Statement

Skeletal Muscle Excitation-Contraction coupling, ryanodine receptors L-type Ca2+ Channels and diseases of skeletal muscle.

Websites

Selected Publications

• Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL "AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.." Nat. Med.. 2012;18(2):244-51. Pubmed PMID: 22231556
• Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E "Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.." Neuron. 2008 Dec 10;60(5):832-45. Pubmed PMID: 19081378
• Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL "RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice.." Cell. 2008 Apr 4;133(1):53-65. Pubmed PMID: 18394989
• Andronache Z, Hamilton SL, Dirksen RT, Melzer W "A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.." Proc. Natl. Acad. Sci. U.S.A.. 2009 Mar 17;106(11):4531-6. Pubmed PMID: 19246389