Positions
- Associate Professor
-
Department of Pathology & Immunology
Baylor College of Medicine
Houston, Texas United States
Addresses
- Texas Children's Hospital (Lab)
-
Department of Pathology
1102 Bates Street FC830.20
Houston, TX 77030
United States
Education
- PhD from University of Buenos Aires, School of Biochemistry and Pharmacy
- Buenos Aires, Capital Federal Argentina
- Visiting Fellow from National Institutes of Health
- Bethesda, Maryland United States
- Senior Research Scientist from Memorial Sloan-Kettering Cancer Center
- New York, New York United States
Professional Interests
- Genetic regulation of blood formation including the immune system
- Pathobiology and treatment of myeloid and lymphoid leukemia
- Mechanisms of self-renewal in normal and leukemic hematopoietic stem cells
Websites
Selected Publications
- Yamada T, Park CS, Mamonkin M, Lacorazza HD "Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2.." Nat. Immunol.. 2009 Jun;10(6):618-26. Pubmed PMID: 19412182
- Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JP, Lacorazza HD. "Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.." Leukemia. 2017; Pubmed PMID: 27872496
- Chun Shik Park 1, Andrew H Lewis 1 2, Taylor J Chen 1 2, Cory S Bridges 1, Ye Shen 1 2, Koramit Suppipat 3, Monica Puppi 1, Julie A Tomolonis 4, Paul D Pang 2, Toni-Ann Mistretta 1, Leyuan Ma 5, Michael R Green 5, Rachel Rau 6, H Daniel Lacorazza 1 "A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells." Blood. 2019 Nov 28;134(22):1960-1972. Pubmed PMID: 31515251
- Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD "The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells.." Cancer Cell. 2006 Mar;9(3):175-87. Pubmed PMID: 16530702
Funding
- Mechanisms of KLF4 suppression in pediatric leukemia - #1R01CA207086 (03/09/2017 - 02/28/2022) Grant funding from National Cancer Institute (NIH)
- Bridge Award Grant funding from American Society of Hematology
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