Email

viveks@bcm.edu

Positions

Assistant Professor of Surgery

Division of Cardiothoracic Surgery
Baylor College of Medicine
Houston, Texas

Addresses

BCM-Jewish Institute for Research (Lab)

Room: BCMD-R412
Houston, TX 77030
United States
Phone: (713) 798-3227
viveks@bcm.edu

Education

PhD from Sanjay Gandhi Post Graduate Institute of Medical Sciences

01/2006 - Lucknow, Uttar Pradesh India

Medical Genetics

MS from Dr. Ram Manohar Lohia, Avadh University

05/2001 - Faizabad, Uttar Pradesh India

Biochemistry

Honors & Awards

Best Junior Faculty Award

5th Annual Cardiovascular Research Institute (CVRI) Symposium

Baylor College of Medicine, Houston, TX, USA (04/2017)

Outstanding New Investigator Award-Council of Basic Cardiovascular Sciences

American Heart Association (AHA) Scientific Session, Las Vegas, USA (07/2014)

Early Career Investigator Award, Council of Basic Cardiovascular Sciences

American Heart Association Scientific Session (08/2014 - 08/2014)

Outstanding Investigator Award -North American Section Meeting (pathology and treatment of heart failure)

International Society of Heart Research (ISHR), Banff, Canada (05/2012)

American Heart Association Fellowship Award-Great-Rivers Affiliate

American Heart Association, USA (07/2010 - 06/2012)

Young Investigator's Award-Cardiac Regulatory Mechanisms

Gordon Research Conference (GRC), New London, New Hampshire, USA (06/2010)

Best Research Award

Scott and White Hospital, Texas AandM University, Texas, USA (05/2009)

Outstanding Research Award-Internal Medicine Day

Scott and White Hospital, Texas AandM University, Texas, USA (06/2008)

Outstanding Research Award-Cardiovascular Research Retreat

Texas AandM University, Health Science Center, Texas, USA (04/2007)

Outstanding Research Award-Cardiovascular Research Retreat

Texas AandM University, Health Science Center, Texas, USA (03/2006)

University Gold Medalist-Master of Science

Dr. R.M.L. Avadh University Faizabad, Uttar Pradesh, INDIA (05/2001)

Professional Interests

• Hypertension/ Arrhythmia • Ischemia and Reperfusion • Diabetic Cardiomyopathy • Cellular Reprogramming • Diabetes/obesity • Gene Therapy

Professional Statement

Dr. Vivek Singh’s research focuses on molecular and genetic mechanisms that mediate myocardial remodeling and heart failure, and the development of new drug and gene-based therapies for heart disease. The research Dr. Singh accomplished during his doctoral and post-doctoral tenures has significantly contributed to a better understanding of the biochemical, molecular, and genetic mechanisms that regulate cardiac function. A significant amount of Dr. Singh work has focused on the renin-angiotensin system and its direct involvement in mediating cell growth in the heart. Dr. Singh has characterized an intracardiac intracellular renin-angiotensin system and has shown that the precursor genes of the system significantly modulate a number of pathological conditions such as diabetic cardiomyopathy. Recently, he identified the genetic biomarkers predisposing to sudden death in heart failure patients and studied the underlying mechanism of ventricular arrhythmias and increased risk of sudden cardiac death in dilated cardiomyopathy. More recently, Dr. Singh examined key developmental cardiac regulators, known as transcription factors GMT (GATA4, MEF2C and TBX5), that reprogram cardiac fibroblasts into functional, beating cardiomyocytes, a novel, promising gene therapy strategy to treat heart failure. Dr. Vivek has a vast experience working on cardiac myocytes and fibroblast both in vitro and in vivo, especially in cardiac electrophysiology. The overall summary of his work is to better understand the molecular signaling pathways, to identify genetic biomarkers and gene regulatory events that modulate cardiac function, and to better understand how these mechanisms may contribute to the development of interventions to modulate heart failure.

Websites

Selected Publications

• Vivek P Singh, Jaya Pratap Pinnamaneni , Aarthi Pugazenthi , Deepthi Sanagasetti, Megumi Mathison , Kai Wang , Jianchang Yang , Todd K Rosengart "Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming." JAHA. 2020 June 16; 16 (9(12)): e015686. Pubmed PMID: 32500803
• Ravi K Ghanta, Samira Aghlara-Fotovat, Aarthi Pugazenthi, Christopher T Ryan, Vivek P Singh, Megumi Mathison, Maria I Jarvis, Sudip Mukherjee, Andrea Hernandez , Omid Veiseh "Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium." Biomaterial Science. 2020 September 15; 8 (18): 5061-5070. Pubmed PMID: 32797143
• Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK. "p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells.." J Thorac Cardiovasc Surg.. 2018 April 13; : S0022-5223(18)30986-3.. Pubmed PMID: 29716728
• Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS; Cancer Genome Atlas Research Network, Sood AK, Gunaratne PH, Sumazin P. "Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context." Cell Report. 2018 April 3; 23 (1): 297-312.e12. Pubmed PMID: 29617668

Funding

Cell Plasticity-Based Reprogramming Strategies to Enhance Human Myocardial Regeneration - #HL 152280

(04/01/2020 - 03/31/2024) Grant funding from NIH R01-Co Investigator

This grant supports research studies to investigate cell plasticity-based reprogramming myocardial regeneration

In situ Cardiac Infarct Cellular Reprogramming - #HL121294-01A1

(09/01/2015 - 02/28/2019) Grant funding from NIH/NHLBI R01-Co Investigator

Reprogramming cardiac fibroblasts into cardiac-like myocytes in vitro/in vivo for potential use in regenerative medicine

(AHA)

(07/01/2010 - 06/30/2012) Grant funding from American Heart Association