Email

coffin@bcm.edu

Positions

Graduate Student

Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US

Education

BS from University of Iowa

05/2013 - Iowa City, IA

Health and Human Physiology

MS from Temple University

05/2017 - Philadelphia, PA

Bioinformatics

Professional Interests

• Zoghbi Lab
• Neurodegeneration, Genomics, Gene Therapy

Selected Publications

• Ramachandran S, Coffin SL, Tang TY, Jobaliya CD, Spengler RM, Davidson BL. "Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts." Human Molecular Genetics. 2016 November 15; : Pubmed PMID: 28171541
• Nitschke L, Tewari A, Coffin SL, Xhako E, Pang K, Gennarino VA, Johnson JL, Blanco FA, Liu Z, Zoghbi HY. "miR760 regulates ATXN1 levels via interaction with its 5' untranslated region." Genes & Development. 2020 August 1; : Pubmed PMID: 32763910
• Nitschke L, Coffin SL, Xhako E, El-Najjar DB, Orengo JP, Alcala E, Dai Y, Wan YW, Liu Z, Orr HT, Zoghbi HY. "Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1." JCI Insight. 2021 February 8; : Pubmed PMID: 33554954

Funding

Brain region specific contribution of the ATXN1/CIC interaction to spinocerebellar ataxia type 1 - #1F31NS115296-01

Grant funding from NIH NINDS NRSA