Scott
Middle Name
Edward
Wenderfer, M.D.-Ph.D.
Middle Name
Edward
Picture
Positions
- Associate Professor
-
Pediatrics
Renal
Baylor College of Medicine
Houston, TX US
Addresses
- Renal Service (Clinic)
-
Texas Children's Hospital
6701 Fannin St., 11th Floor
Houston, TX 77030
United States
(832) 824-3800
http://www.texaschildrens.org/departments/kidney-renal
- Renal Laboratory (Lab)
-
1102 Bates St., Suite C.0720.01
Feigin Center
Houston, TX 77030
United States
(832) 824-3886
- Office (Office)
-
1102 Bates St., Suite C.0720.06
Texas Children's Hospital
Houston, TX 77030
United States
(832) 824-3873
wenderfe@bcm.edu
Wenderfer BCM Page
Education
- MD from University Of Cincinnati College Of Medicine
- 07/2001 - Cincinnati, Ohio United States
- BS from University Of Notre Dame
- 06/1993 - Notre Dame, Indiana United States
- Biology
- Fellowship at University Of Texas At Houston
- 06/2006 - Houston, Texas United States
- Pediatric Nephrology
- Residency at University Of Texas At Houston
- 06/2004 - Houston, Texas United States
- Pediatrics
- PhD from University Of Cincinnati College Of Medicine
- 07/2001 - Cincinnati, Ohio United States
- Molecular Genetics, Biochemistry, and Microbiology
Certifications
- Physician
- (09/01/2014 - 12/17/2020)
- American Board of Pediatrics
Honors & Awards
- Leadership Development Program
- American Society of Pediatric Nephrology (05/2013 - 05/2014)
Professional Interests
- Immune Complex Glomerulonephritis
- Pediatric Clinical Trials
- Clinical Research
- Translational Research
- Mouse Models of Disease
- Tissue culture
- Genetic Kidney Diseases
- Dialysis
- Pheresis
- Kidney biopsy
Websites
Professional Development
- MWPNC 2019 Fall Meeting
- Workshop (Presenter, 2019)
- Sponsor: Midwest Pediatric Nephrology Consortium
- Kidney Week 2019
- Conference (Participant, 2019)
- Sponsor: American Society of Nephrology
- 21st Centuray Lupus Conference
- Conference (Presenter, 2018)
- CARRA 2019
- Conference (Organizer, 2019)
- Sponsor: Childhood Arthritis and Rheumatology Research Alliance
- CARRA 2018
- Conference (Organizer, 2018)
- Sponsor: Childhood Arthritis and Rheumatology Research Alliance
- CARRA 2017
- Conference (Organizer, 2017)
- Sponsor: Childhood Arthritis and Rheumatology Research Alliance
- CARRA 2016
- Conference (Organizer, 2016)
- Sponsor: Childhood Arthritis and Rheumatology Research Alliance
- CARRA 2014 Spring Meeting
- Workshop (Presenter, 2014)
- Sponsor: Childhood Arthritis and Rheumatology Research Alliance
- PRYSM 2017
- Conference (Presenter, 2017)
- Sponsor: American College of Rheumatology
- PRSYM 2014
- Conference (Presenter, 2014)
- Sponsor: Pediatric Rheumatology
- 2014 Pediatric Academic Societies Meeting
- Conference (Presenter, 2014)
- Sponsor: American Society of Pediatric Nephrology
- Kidney Week 2013
- Conference (Participant, 2013)
- Sponsor: American Society of Nephrology
- 2012 Pediatric Academic Societies Meeting
- Conference (Presenter, 2012)
- Sponsor: American Society of Pediatric Nephrology
- Kidney Week 2018
- Conference (Presenter, 2018)
- Sponsor: American Society of Nephrology
- Kidney Week 2017
- Conference (Participant, 2017)
- Sponsor: Percentage of Glomerular Crescents Predicts Renal Outcomes in Children with IgA Vasculitis - a Midwest Pediatric Nephrology Consortium Study
- Kidney Week 2016
- Conference (Presenter, 2016)
- Sponsor: Percentage of Glomerular Crescents Predicts Renal Outcomes in Children with IgA Vasculitis - a Midwest Pediatric Nephrology Consortium Study
- Kidney Week 2015
- Conference (Presenter, 2015)
- Sponsor: Crescentic Glomerulonephritis in Children
Selected Publications
- Dhande, Zhu, Kneedler, Joshi, Hicks, Wenderfer, Braun, Doris "Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension." J Am Heart Assoc. 2020 9 (5): e014142. Pubmed PMID: 32075490
- Hanson, Wenderfer, et al. "Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study." Am J Kidney Dis. 74 (1): 82-94. Pubmed PMID: 30885704
- Mariani, Bomback, Canetta, Flessner, Wenderfer, et al. "Cure Glomerulonephropathy Network (CureGN): Rational and Study Design." Am J Kidney Dis. 2018 73 (2): 218-229.
- Suwanichkul, A, Wenderfer SE "Differential expression of functional Fc-receptors and additional immune complex receptors on mouse kidney cells." Molecular Immunology. 2013 56 (4): 369-79. Pubmed PMID: 23911392
- Rovin, Caster, Cattran, Gibson, Hogan, Moeller, Roccatello, Cheung, Wheeler, Winkelmayer, Floege, Wenderer, et al. "Management and treatment of glomerular diseases (part2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference." KIdney Int. 2019 92 (2): 281-295. Pubmed PMID: 30665569
- Floege, Barbour, Cattran, Hogan, Nachman, Tang, Wetzels, Cheung, Wheeler, Winkelmayer, Rovin, Wenderer, et al. "Management and treatment of glomerular diseases (part1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference." KIdney Int. 2019 95 (2): 268-280. Pubmed PMID: 30665568
- Wenderfer SE, Swinford RD, Braun MC "C1q nephropathy in the pediatric population: pathology and pathogenesis.." Pediatr. Nephrol.. 2010 August ; 25 (8): 1385-96. Pubmed PMID: 20180137
- Canetta, Wenderfer, et al. "CureGN Consortium. Health-related quality of life in glomerular disease." KIdney Int. 2019 95 (5): 1209-1224. Pubmed PMID: 30898342
- Dhande, Kneedler, Joshi, Zhu, Hicks, Wenderfer, Braun, Doris "Germ-line Genetic Variation in the Immunoglobulin heavy chain Creates Stroke Susceptibility in the Spontaneously Hypertensive Rat." Physiol Genomics. 2019 51 (11): 578-585.
- Ardoin, Daly, Merzoug, Tse, Ardalan, Arkin, Knight, Rubinstein, Ruth, Wenderfer, Hersh "Research Priorities in Childhood-Onset Lupus: Results of a Multidisciplinary Prioritization Exercise." Pediatric Rheum Obline J. 2019 17 (1): 32.
- Brunner, Holland, Beresford, Ardoin, Appenzeller, Silva, Flores, Goilav, Avar Aydin, Wenderfer, et al. "American College of Rheumatology Provisional criteria for clinically relevant improvement in children and adolescents with childhood-onset systemic lupus erythematosus." Arthritis Care Res. 2019 71 (5): 579-590. Pubmed PMID: 30680946
- HI Brunner, M Holland, MW B, N Ruperto, SP Ardoin, S Appenzeller, CA Silva, F Flores, B Goilav, SE Wenderfer, DM Levy, A Ravelli, R Khunchandani, T Avcin, MS Klein-Gitelman, BM Feldman, J Ying "American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. Arthritis Care and Research." Arthritis Care and Research. 2018 : Pubmed PMID: 29693328
- MN Rheault, SE Wenderfer "Evolving Epidemiology of Pediatric Glomerular Disease." CJASN. 2018 : Pubmed PMID: 29915130
- T Gutman, CS Hanson, S Bernays, JC Craig, A Sinha, A Dart, AA Eddy, M Michael, SE Wenderfer, A Tong, et al. "Child and parental perspectives on communication and decision-making in chronic kidney disease." American Journal of Kidney Disease. 2018 :
- Selewski, Ambruzs, Appel, Bomback, Matar, Cai, Cattran, Chishti, D'Agati, D'Alessandri-Silva, Gbadegesin, Hogan, Iragorri, Jennette, Julian, Khalid, Lafayette, Liapis, Wenderfer, et al. "Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study." Kidney Int Reports. 2018 3 (6): 1373-1384. Pubmed PMID: 30450464
- Vasylyeva, Díaz-González de Ferris, Hains, Ho, Harshman, Reidy, Brady, Okamura, Samsonov, Wenderfer, Hartung "Developing a Research Mentorship Program: The American Society of Pediatric Nephrology’s Experience." Frontiers in Pediatrics. 2019 7 : 155.
- Wenderfer SE, Ruth NM, Brunner HI "Advances in the care of children with lupus nephritis." Pediatr Res. 2017 January 4; : Pubmed PMID: 27855151
- Hamdani G, Nehus EJ, Hanevold CD, Sebestyen Van Sickle J, Woroniecki R, Wenderfer SE, Hooper DK, Blowey D, Wilson A, Warady BA, Mitsnefes MM "Ambulatory Blood Pressure, Left Ventricular Hypertrophy, and Allograft Function in Children and Young Adults After Kidney Transplantation." Transplantation. 2017 January ; 101 (1): 150-156. Pubmed PMID: 26895218
- Dhande I, Zhu Y, Braun MC, Hicks MJ, Wenderfer SE, Doris PA "Mycophenolate Mofetil Prevents Cerebrovascular Injury in Stroke-prone Spontaneously Hypertensive Rats." Physiol Genomics. 2016 December 23; 49 (3): 132-140. Pubmed PMID: 28011882
- Wenderfer SE, Lane JC, Shatat IF, von Scheven E, Ruth NM "Practice patterns and approach to kidney biopsy in lupus: a collaboration of the Midwest Pediatric Nephrology Consortium and the Childhood Arthritis and Rheumatology Research Alliance." Pediatr Rheumatol Online J. 2015 13 : 26. Pubmed PMID: 26087651
- J Alge, SE Wenderfer "The Hemolytic Uremic Syndrome." J Pediatrics. 2018 : Pubmed PMID: 29801537
- Boneparth A, Radhakrishna SM, Greenbaum LA, Yen E, Okamura DM, Cooper JC, Mason S, Levy DM, Sule SD, Jensen PT, Yildirim-Toruner C, Ardoin SP, Wenderfer SE "Approach to Membranous Lupus Nephritis: A Survey of Pediatric Nephrologists and Pediatric Rheumatologists." J Rheumatol. 2017 44 (11): 1619-1623. Pubmed PMID: 28916546
- Holland MJ, Beresford MW, Feldman BM, Ravelli A, Wenderfer SE, Ruperto N, Brunner HI, et al.; PRINTO PRCSG Investigators "Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus." Arthritis Care Res. 2018 : Pubmed PMID: 29409150
- Dhande IS, Cranford SM, Zhu Y, Kneedler SC, Hicks MJ, Wenderfer SE, Braun MC, Doris PA "Susceptibility to Hypertensive Renal Disease in the Spontaneously Hypertensive Rat Is Influenced by 2 Loci Affecting Blood Pressure and Immunoglobulin Repertoire." Hypertension. 2018 71 (4): 700-708. Pubmed PMID: 29437896
- Pereira M, Muscal E, Eldin K, Hicks MJ, Sagcal-Gironella ACP, DeGuzman M, Wenderfer SE "Clinical presentation and outcomes of childhood-onset membranous lupus nephritis." Pediatr Nephrol. 2017 32 (12): 2283-2291.
- Wenderfer SE, Gaut JP "Glomerular Diseases in Children." 2017 24 (6): 364-371. Pubmed PMID: 29229167
- Alge JL, Wenderfer SE, Hicks J, Bekheirnia MR, Schady DA, Kain JS, Braun MC "Hemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report." BMC Nephrol. 2017 18 (1): 243. Pubmed PMID: 28720077
- Singla S, Wenderfer SE, Muscal E, Sagcal-Gironella ACP, Orange JS, Makedonas G "Changes in Frequency and Activation Status of Major CD4+ T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus." Front Pediatr. 2017 5 : 104. Pubmed PMID: 28555177
- Bekheirnia MR, Wenderfer SE, Gibbs RA, Belmont JW, Braun MC, Lupski JR, Lamb DJ, et al. "Whole-exome sequencing in the molecular diagnosis of individuals with congenital anomalies of the kidney and urinary tract and identification of a new causative gene." Genet Med. 2017 19 (4): 412-420. Pubmed PMID: 27657687
- Boneparth A, Wenderfer SE, Moorthy LN, Radhakrishna SM, Sagcal-Gironella AC, von Scheven E; CARRA Registry investigators "Clinical characteristics of children with membranous lupus nephritis: the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry." Lupus. 26 (3): 299-306. Pubmed PMID: 27510603
- Potter SL, Venkatramani R, Wenderfer S, Graham BH, Vasudevan SA, Sher A, Wu H, Wheeler DA, Yang Y, Eng CM, Gibbs RA, Roy A, Plon SE, Parsons DW "Renal cell carcinoma harboring somatic TSC2 mutations in a child with methylmalonic acidemia." Pediatr Blood Cancer. 2016 October 17; : Pubmed PMID: 27748010
- Orjuela A, Suwanichkul A, Canter D, Minard CG, Devaraj S, Hicks MJ, Muscal E, Wenderfer SE "High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus." Am J Nephrol. 2015 41 (3): 241-7. Pubmed PMID: 25926050
- Campbell JF, Swartz SJ, Wenderfer SE "Nocturnal Hypertension and Attenuated Nocturnal Blood Pressure Dipping is Common in Pediatric Lupus." F1000Res. 2015 4 : 164. Pubmed PMID: 26664705
- SE Wenderfer "Viral-associated glomerulopathies in children." Pediatr Nephrol. 2015 30 (11): 1929-1938. Pubmed PMID: 25752759
- Braun MC, Herring SM, Gokul N, Monita M, Bell R, Zhu Y, Gonzalez-Garay ML, Wenderfer SE, Doris PA "Hypertensive renal injury is associated with gene variation affecting immune signaling." Circ Cardiovasc Genet. 2015 7 (6): 903-910. Pubmed PMID: 25366137
- Braun MC, Herring SM, Gokul N, Monita M, Bell R, Hicks MJ, Wenderfer SE, Doris PA "Hypertensive renal disease: susceptibility and resistance in inbred hypertensive rat lines." J Hypertens. 2013 31 (10): 2050-9. Pubmed PMID: 24107734
- Wenderfer SE "Can inhibition of proteasomes or NF-kappaB help control idiopathic nephrotic syndrome?." Nephrol. Dial. Transplant.. 2012 May ; 27 (5): 1698-701. Pubmed PMID: 22547747
- Wenderfer SE, Thacker T "Intravenous immunoglobulin in the management of lupus nephritis.." Autoimmune Dis. 2012 2012 : 589359. Pubmed PMID: 23056926
- Herring SM, Gokul N, Monita M, Bell R, Boerwinkle E, Wenderfer SE, Braun MC, Doris PA "Immunoglobulin locus associates with serum IgG levels and albuminuria.." J. Am. Soc. Nephrol.. 2011 May ; 22 (5): 881-9. Pubmed PMID: 21454716
- Wenderfer SE, Wang H, Ke B, Wetsel RA, Braun MC "C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse.." Mol. Immunol.. 2009 April ; 46 (7): 1397-404. Pubmed PMID: 19167760
- Wenderfer SE, Dubinsky WP, Hernandez-Sanabria M, Braun MC "Urine proteome analysis in murine nephrotoxic serum nephritis.." Am. J. Nephrol.. 2009 30 (5): 450-8. Pubmed PMID: 19776558
- Wenderfer SE, Stepkowski SM, Braun MC "Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist.." Kidney Int.. 2008 November ; 74 (10): 1319-26. Pubmed PMID: 18769369
- Wenderfer SE, Soimo K, Wetsel RA, Braun MC "Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.." Arthritis Res. Ther.. 2007 9 (5): R114. Pubmed PMID: 17971229
- Wenderfer SE, Swinford RD, Mauiyyedi S, Witte DP, Braun MC "Cytomegalovirus and recurrent idiopathic membranoproliferative glomerulonephritis type 1: cause or consequence?." Transplantation. 2007 February 27; 83 (4): 523-4. Pubmed PMID: 17318089
- Wenderfer SE, Ke B, Hollmann TJ, Wetsel RA, Lan HY, Braun MC "C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice.." J. Am. Soc. Nephrol.. 2005 December ; 16 (12): 3572-82. Pubmed PMID: 16207826
- Wenderfer SE, Monaco JJ "Exon trapping for positional cloning and fingerprinting.." Methods Mol. Biol.. 2004 256 : 41475. Pubmed PMID: 15024156
- Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11.." Genomics. 2000 February 1; 63 (3): 354-73. Pubmed PMID: 10704283
- Grandea AG, Comber PG, Wenderfer SE, Schoenhals G, Früh K, Monaco JJ, Spies T "Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly.." Immunogenetics. 1998 September ; 48 (4): 260-5. Pubmed PMID: 9716645
Memberships
- American Society of Nephrology
- Member (07/2004)
- American Society of Pediatric Nephrology
- Member (07/2004)
- National Kidney Foundation
- Member (01/2008)
- Midwest Pediatric Nephrology Consortium
- Member (09/2013)
- Childhood Arthritis and Rheumatology Research Alliance
- Associate-Member (03/2014)
- International Pediatric Hypertension Association
- Member (07/2004)
- International Pediatric Nephrology Association
- Member (01/2012)
- American Association of Immunologists
- Member (07/2003)
- International Complement Society
- Member (07/2003)
- American Association of Pediatrics
- Member (11/2011)
- American Medical Association
- Member (11/2011)
Funding
- Learning Health Systems for Pediatric Lupus Nephritis Research - #DK114786 (09/01/2018 - 08/31/2020) Grant funding from NIDDK
- Pilot award from the CHOP Pediatric Center of Excellence in Nephrology using the PEDSNet database
- Improving Pediatric Lupus Nephritis through Personalized MMF Therapy - #AR071651 (09/01/2018 - 06/30/2020) Grant funding from NIAMS
- LUpus Nephritis and Cellcept precision dosing in cHildren (LaUNCH) will prepare for a clinical trial called PLUMM (Pediatric Lupus Nephritis on Mycophenolate Mofetil)
- CureGN: Integrative Proteomics and Metabolomics for Pediatric Glomerular Disease Biomarkers - #DK100866 (06/01/2014 - 06/30/2024) Grant funding from NIDDK
- This study is enrolling and following 2400 patients with glomerular disease in a prospective registry
- Immun Complex Receptors in the Kidney - #DK-081663 (09/01/2009 - 08/31/2014) Grant funding from NIDDK
- Immunoglobulin Receptors and Immune Complex Processing in the Kidney
- Young Investigator Grant ( Grant funding from National Kidney Foundation
- Immune Complex Receptors on Cells of the Glomerulus
- The C1q Nephropathy Study (01/01/2020 - 12/31/2020) Grant funding from Nephcure Kidney International
- This project uses the Cure Glomerulopathy Network (CureGN) which has enrolled 2400 patients with nephrotic syndrome, to study clinical, pathologic, genetic, and autoimmune characteristics of an important subset of patients: those with C1q Nephropathy.
Skills
- Immunology
- Pediatric Nephrology
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