Positions
- Postdoc Fellow-PhD
-
Pathology
Baylor College of Medicine
Houston, TX US
Education
- BS from Biola University
- 12/2004 - La Mirada, California United States
- Biology
- MS from California State University Long Beach
- 08/2008 - Long Beach, California United States
- Microbiology
- PhD from University of Cincinnati
- 04/2014 - Cincinnati, Ohio United States
- Systems Biology and Physiology
Honors & Awards
- AGA Fellow Abstract Prize
- American Gastroenterological Association (AGA) (06/2018)
- IHMC Early Career Bursary
- International Human Microbiome Consortium (IHMC) (06/2018)
- Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award
- American Physiological Society (05/2018)
- FASEB Gastrointestinal Tract XVI Poster Award
- Federation of American Societies for Experimental Biology (FASEB) (07/2017)
- FASEB Gastrointestinal Tract XVI Travel Award
- Federation of American Societies for Experimental Biology (FASEB) (07/2017)
- DDW Basic Science Travel Award
- Digestive Disease Week (DDW) (05/2017)
- AGA Early Career Investigator Award
- American Gastroenterological Association (AGA) (06/2018)
- AGA Early Career Investigator Award
- American Gastroenterological Association (AGA) (05/2017)
- NextProf Science Future Faculty Workshop Scholarship
- University of Michigan (06/2016)
- APS Gastrointestinal and Liver Section Takeda Research Award
- American Physiological Society (05/2016)
- FASEB Gastrointestinal Tract XV Poster Award
- Federation of American Societies for Experimental Biology (FASEB) (07/2015)
- APS Gastrointestinal and Liver Section Takeda Research Award
- American Physiological Society (05/2015)
- APS Gastrointestinal and Liver Physiology Section Trainee Poster Award
- American Physiological Society (05/2014)
- DDW Poster of Distinction
- Digestive Disease Week (05/2015)
- APS Cellular and Molecular Physiology (CAMPs) Robert Gunn Student Award
- American Physiological Society (05/2014)
- BCM Postdoctoral “Slice of Science” Symposium Presentation Competition Award Winner 1st Place
- Baylor College of Medicine (11/2017)
- Texas Medical Center Frontiers in Digestive Diseases Symposium Poster Award Winner 1st place
- Baylor College of Medicine (02/2018)
- Annual Postdoctoral Science Symposium Platform Presentation Competition Award Winner 3rd Place
- MD Anderson Cancer Center (09/2017)
- Annual Postdoctoral Science Symposium Platform Presentation Competition Award Winner 3rd Place
- MD Anderson Cancer Center (09/2016)
- Texas Medical Center Frontiers in Digestive Diseases Symposium Poster Award Winner 1st place
- Baylor College of Medicine (02/2016)
- UC Systems Biology and Physiology Retreat Award Winner 1st place
- University of Cincinnati (01/2014)
- UC Graduate Student Research Forum Award Winner 1st place
- University of Cincinnati (10/2013)
- UC Graduate Student Scholarship Award
- University of Cincinnati (09/2012)
- UC Graduate Student Research Forum Award Winner 3rd Place
- University of Cincinnati (10/2012)
- UC Choose Ohio First Scholarship Recipient Ohio Board of Regents
- University of Cincinnati (09/2009)
- AGA Women’s Leadership Conference Selected Attendee
- American Gastroenterological Association (AGA) (03/2019 - 03/2019)
- AGA Basic Science Plenary Oral Presentation
- Digestive Disease Week (DDW) (05/2019 - 05/2019)
- AGA Women’s Leadership Conference Selected Attendee
- merican Gastroenterological Association (AGA) (02/2019 - 02/2019)
- Precision Environmental Health: Integrating Environmental Sciences, Genomics, and Data Science to Advance Human Health Poster Award Winner
- Annual Keck Research Conference (11/2019 - 11/2019)
- ASIP George K. Michalopoulos Junior Faculty Travel Award
- American Society of Investigative Pathology (04/2020)
Professional Interests
- Intestinal mucins and glycosylation
- Host-bacterial interactions
- Bacterial modulation of cancer mucins
Websites
Selected Publications
- Engevik MA, Hickerson A, Shull GE, Worrell RT. "Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides.." Cell Physiol Biochem. 2013 : Pubmed PMID: 24429819
- Haar L, Ren X, Liu Y, Koch SE, Goines J, Tranter M, Engevik MA, Nieman ML, Rubinstein J, Jones WK. "Consumption of high fat diet acutely prior to ischemia/reperfusion results in cardioprotection through NF-κB dependent regulation of autophagic pathways.." AJPheart. 2014 September ; : Pubmed PMID: 25239807
- Donnelly JM, Engevik AC, Engevik M, Schumacher MA, Xiao C, Yang L, Worrell RT, Zavros Y. "Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.." Dig Dis Sci. 2014 : Pubmed PMID: 24202649
- Engevik MA, Aihara E, Montrose MH, Shull GE, Hassett DJ, Worrell RT. "Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth.." AJP-GI. 2013 : Pubmed PMID: 24072680
- Engevik MA, Faletti CJ, Paulmichl M, Worrell RT. "Prebiotic properties of galursan HF 7K on mouse gut microbiota.." Cell Physiol Biochem. 2013 : Pubmed PMID: 24429818
- Engevik MA, Yacyshyn MB, Engevik KA, Wang J, Darien B, Hassett DJ, Yacyshyn BR, Worrell RT "Human Clostridium difficile infection: Altered mucus production and composition." AJP-GI. 2015 March ; 306 (6): G510-24. Pubmed PMID: 25552581
- Engevik MA, Engevik KA, Yacyshyn MB, Wang J, Hassett DJ, Darien B, Yacyshyn BR, Worrell RT "Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile." AJP-GI. 2015 March ; 308 (6): G497-509. Pubmed PMID: 25552580
- Shawki A, Anthony SR, Nose Y, Engevik MA, Niespodzany EJ, Barrientos T, Ohrvik H, Worrell RT, Thiele DJ, Mackenzie B. "Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese." 2015 August 20; : Pubmed PMID: 26294671
- Luk B, Veeraragavan, Engevik M, Balderas M, Major A, Runge J, Luna RA1, Versalovic J "Postnatal colonization with human "infant-type" Bifidobacterium species alters behavior of adult gnotobiotic mice." PLOS ONE. 2018 May ; 13 (5): e0196510. Pubmed PMID: 5953436
- Hayley Coffing, Shubha Priyamvada, Arivarasu Natarajan Anbazhagan, Christine Salibay, Melinda Engevik, James Versalovic, Mary Yacyshyn, Bruce Yacyshyn, Sangeeta Tyagi, Seema Saksena, Ravinder Gill, Waddah Alrefai, and Pradeep Dudeja "Clostridium difficile Toxins A and B Decrease SLC26A3 Protein Expression in Human Intestinal Epithelial Cells." AJP-GI. 2018 July ; 15 (1): G43-G52. Pubmed PMID: 6109705
- Engevik AC1, Kaji I1, Engevik MA2, Meyer AR3, Weis VG, Goldstein A, Hess MW, Müller, Koepsell H, Dudeja P, Tyska M, Huber L, Shub MD, Ameen N, Goldenring JR "Loss of MYO5B Leads to Reductions in Na+ Absorption with Maintenance of CFTR-dependent Cl- Secretion in Enterocytes.." Gastroenterology. 2018 July ; : Pubmed PMID: 30144427
- 4. Hornstein BD, Roman D, Arévalo-Soliz LM, Engevik MA, Zechiedrich L "Effects of Circular DNA Length on Transfection Efficiency by Electroporation into HeLa Cells." PLoS One. 2016 December ; 11 (12): e0167537.
- 5. Shawki A, Engevik MA, Kim RS, Knight PB, Baik RA, Anthony SR, Worrell RT, Shull GE, Mackenzie B. "Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse." Am J Physiol Gastrointest Liver Physiol. 2016 September ; 311 (3): G423-30.
- 14. Engevik MA, Versalovic J "Bugs as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease. ‘Targeted selection of commensal bacteria for applications in therapeutic microbiology’." American Society for Microbiology Press. 2016 :
- Shi Z, Fultz RS, Engevik MA, Gao C, Hall A, Major A, Mori-Akiyama Y, Versalovic J. "Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis.." AJP-GI. 2019 : Pubmed PMID: 30462522
- Ihekweazu FD, Fofanova TY, Queliza K, Nagy-Szakal D, Stewart CJ, Engevik MA, Hulten KG, Tatevian N, Graham DY, Versalovic J, Petrosino JF, Kellermayer R. "Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model.." Gut Microbes. 2019 : Pubmed PMID: 30663928
- Chang-Graham AL, Danhof H, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM "Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion." CMGH. 2019 : Pubmed PMID: 31029854
- Engevik MA, Luk B, Hall A, Chang-Graham A, Herrmann B, Endres B, Shi Z, Garey KW, Hyser J, Versalovic J "Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways." mBIO. 2019 :
- Melinda Engevik, James Versalovic "Taking a Closer Look at the Biogeography of the Human Gastrointestinal Microbiome." Gastroenterology. 2019 July ; :
- Fultz R, Engevik MA, Shi Z, Hall A, Herrmann B, Ganesh BP, Major A, Haag A, Mori-Akiyama Y, Versalovic J. "Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.." Microbiologyopen. 2019 : Pubmed PMID: 31369218
- "ClC transporter activity modulates histidine catabolism in Lactobacillus reuteri by altering intracellular pH and membrane potential.." Microb Cell Fact. 2019 : Pubmed PMID: 31830990
- "Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.." Frontiers Microbiology. 2019 : Pubmed PMID: 31649646
- "Healthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration.." Dig Dis Sci.. 2020 : Pubmed PMID: 32067143
- "Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-lined Inclusions and Alterations in Sodium Transporters.." Gastroenterology. 2020 : Pubmed PMID: 32112796
- Engevik MA, Danhof HA, Chang-Graham A, Spinler J, Engevik KA, Hermann B, Endres BT, Garey KW, Hyser JM, Britton RA, Versalovic J "Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis." AJP-GI. 2020 : Pubmed PMID: 32223302
- Ruan W, Fishman DS, Lerner DG, Engevik MA, Elmunzer JB, Furlano RI, Thompson M, Walsh CM. "Pediatric Endoscopic Practice Change during the COVID-19 Pandemic." Gastroenterology. 2020 : Pubmed PMID: 32485178
- Engevik MA, Banks LD, Engevik KA, Chang-Graham A, Hutchinson DS, Adjami NJ, Petrosino JF, Hyser JM "Rotavirus Infection Induces Segment-specific Changes in the Intestinal Microbiome." Gut Microbes. 2020 : Pubmed PMID: 32404017
- Ruan W*, Engevik MA*, Danhof H, Goodwin A, Chang-Graham AL, Hall A, Di Rienzi SC, Venable S, Britton RA, Hyser J, Versalovic J. "Human jejunal enteroids secrete a unique profile of cytokines in response to host and microbial stimuli." Journal of Physiology. 2020 : Pubmed PMID: 32428244
- Luk B, Engevik MA, Ganesh BP, Lackey EP, Lin T, Balderas M, Major A, Runge J, Luna RA, Sillitoe RV, Versalovic J. "Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial activation." Scientific Reports. 2020 : Pubmed PMID: 32385412
- "Human-derived Bifidobacterium dentium modulates the mammalian serotonergic system and gut-brain axis." CMGH. 2020 : Pubmed PMID: 32795610
- "Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation." Gut Microboes. 2020 : Pubmed PMID: 32804011
Memberships
- American Society of Microbiology (ASM)
- (01/2013)
- American Physiological Society (APS)
- (11/2008)
- American Gastroenterological Association (AGA)
- (01/2015)
- National Postdoctoral Association (NPA)
- (01/2014)
- American Society of Investigative Pathology (ASIP)
- (08/2019)
- International Cytokine and Interferon Society (ICIS)
- (01/2020)
- Society for Glycobiology
- (01/2016)
- Association for Women in Science (AWIS)
- (01/2015)
Funding
- Pediatric GI - #T32DK07644 Ruth L. Kirschstein NRSA Institutional Research Training Grant (T32)
- Pilot Feasibility Award (02/01/2018 - 02/01/2019) Grant funding from Texas Medical Center Digestive Disease Center
- The Texas Medical Center Digestive Diseases Center provides grant funds to support pilot/feasibility (P/F) projects in the area of GI-related research. These funds support projects related to the theme for the DDC - GI infection and injury.
- Career Development Grant for Postdoctoral Women (04/01/2018 - 08/31/2018) Grant funding from American Society for Microbiology
- QuantStudio 3 qPCR Connectivity Equipment Grant (11/01/2015 Grant funding from Applied Biosystems
- Graduate Student Research Fellowship Grant (05/01/2012 - 08/24/2012) Grant funding from University of Cincinnati
- Elucidating the role of dietary cysteine and Bifidobacterium dentium γ-glutamylcysteine in suppressing proinflammatory reactive oxygen species (07/01/2019 - 06/01/2020) Grant funding from Young Investigator Grant for Probiotics Research
- Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repair - #DK123195-01 (01/13/2020 - 01/12/2025) Grant funding from NIDDK K01
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