Positions
- Assistant Professor
-
Neuroscience
Baylor College of Medicine
Houston, TX US
Addresses
- BCM-Smith Medical Research Bldg (Lab)
-
Room: BCMS-S607
Houston, TX 77030
United States
Education
- PhD from Nanjing Agricultural University
- 12/2006 - Nanjing, China
- Postdoctoral Fellowship at Institute of Neuroscience, Chinese Academy of Sciences
- 03/2009 - Shanghai, China
- Postdoctoral Fellowship at Vanderbilt University
- 07/2014 - Nashville, TN
Professional Interests
- Chronic pain, chronic pain-induced mood disorders, opioid analgesic tolerance and addiction.
Professional Statement
The primary research of my group is centered on synaptic and circuitry plasticity mechanisms underlying chronic pain, chronic pain-induced mood disorders, and opioid tolerance and translational studies in chronic pain management. We perform a multi-disciplinary approach to address these issues, including Patch-seq, mouse genetic tools, electrophysiology, behavioral assays, viral-mediated gene transfer, in vitro and in vivo imaging, molecular biology, and biochemistry. We are currently actively recruiting for a postdoctoral fellow, staff scientist, and research assistant with excellent skills/experience in one or more of the following areas: mouse behavior, rodent animal surgery, electrophysiology, imaging, biochemistry.Selected Publications
- Ru Q, Lu Y, Saifullah MAB, Blanco FA, Yao C, Cata JP, Li DP, Tolias KF, and Li L. "Tiam1-mediated synaptic plasticity drives comorbid depressive symptoms in chronic pain." BioRxiv (Under revision based on reviewers’ comments for SCIENCE). :
- Li L, Chen SR, Zhou MH, Wang L, Li DP, Chen H, Lee G, Jayaraman V, and Pan HL "α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly." Cell Rep. 2021 July ; 36 (3): 109396.
- Chen J, Li L (co-first author), Chen SR, Chen H, Xie JD, Sirrieh RE, Maclean DM, Zhang Y, Jayaraman V, and Pan HL. "A novel α2δ-1-NMDA receptor coupling is critically involved in neuropathic pain and gabapentin action." Cell Rep. 2018 22 : 2307-2321.
- Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL "Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain." Cell Rep. 2016 May ; 15(7) : 1376-1383.
- Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV "G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)." J Bio Chem. 2015 April ; 290(17) : 10775-90.
- Li L*, Liu S, Lei Y, Cheng Y, Yao C, Zhen X "Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2." J Neurosci Res. 2014 July ; 92(7) : 835-46.
- Li L, Cheng H, Gai J, Yu D "Genome-wide identification and characterization of putative cytochrome P450 genes in the model legume Medicago truncatula." Planta. 2007 June ; 226 (1) : 109-23.
- Li L, Wang X, Gai J, Yu D "Molecular cloning and characterization of a novel microsomal oleate desaturase gene from soybean." J Plant Physiol. 2007 November ; 164(11) : 1516-26.
Memberships
- Society of Neuroscience
- Gulf Coast Consortium for Translational Pain Research
- Therapeutic Innovation Center at BCM
Funding
- Synaptic structural and functional plasticity underlying transition to chronic pain
- $1,440,000.00 (09/01/2020 - 08/31/2024) Grant funding from DoD Chronic Pain Management Research Program
- Synaptic plasticity mechanism underlying the development of opioid analgesic tolerance and opioid-induced hyperalgesia (OIH)
- $200,000.00 (06/01/2020 - 05/31/2022) Grant funding from Mission Connect/TIRR Foundation
- Synaptic plasticity mechanisms underlying chronic pain-induced depression
- $60,000.00 (01/01/2021 - 12/31/2022) Grant funding from Mission Connect/TIRR Foundation
- Synaptic plasticity mechanisms underlying neuropathic pain following spinal cord injury
- $800,000.00 (09/01/2021 - 08/31/2024) Grant funding from DoD Spinal Cord Injury Research Program
Log In to edit your profile
