Jihye Yun, Ph.D.
Jihye Yun, Ph.D.
- Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine (BCM)
Houston, TX, US
Dan L Duncan Comprehensive Cancer Center (BCM)
Houston, TX, United States
Texas Medical Center (TMC)
Digestive Disease Center (DDC)
The Alkek Center for Metagenomics and Microbiome Research (BCM)
- Postdoctoral Fellowship at Weill Cornell Medicine
- New York, New York, United States
- PhD from Johns Hopkins University, School of Medicine
- Baltimore, Maryland, United States
- MS from Korea Advanced Institute of Science and Technology (KAIST)
- Daejoen, South Korea
- BA from Sogang University
- Seoul, South Korea
- Understanding the role of dietary factors in colorectal cancer pathogenesis (Key words: Cancer Metabolism, Microbiome, Genetic mutations, Mouse models, Organoids)
Professional StatementColorectal cancer is the second leading cause of cancer-related deaths in developed countries. Epidemiological studies strongly suggest that diet is the most important environmental factors in colorectal cancer development. Indeed, diet is known to affect many important aspects of cancer development by influencing epigenetics, metabolism, immune systems and gut microbiota and others. As such, if we can identify and understand the mechanisms by which dietary factors can prevent or facilitate cancer development, we will be able to control cancer initiation, progression and metastasis more effectively. Unfortunatley, the field connecting diet to cancer has been difficult to study experimentally in human. One of the challenges is that it is very hard to control or restrict one’s diet or life style, which can confound the dietary factors in question. Furthermore, it is difficult to dissect the molecular mechanisms of complex relationship between diet and pathogenesis of colorectal cancer in human subjects.
The goal of our laboratory is to identify dietary factors that can affect tumorigenesis and understand the molecular basis for the relationship between diet and colorectal cancer using preclinical model systems. Toward this end, we will use genetically engineered mouse models (GEMM), ex-vivo 3D organoid co-culture systems, and patient or mouse-derived organoid transplantation models. Furthermore, we have the integrative and systematic ‘-omics’ approaches using state-of-the-art techniques such as metabolomics and next-generation sequencing. Ultimately, we seek to develop and discover novel strategies to prevent and treat colorectal cancer and other types of cancer by understanding the role of diet in cancer, which we believe can have a positive impact on society directly and immediately.
- Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIC, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SG, Cantley LC "Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH." Science. 2016 : Pubmed PMID: 26541605
- Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells." Science. 2009 : Pubmed PMID: 19661383
- Gonclaves MD, Lu C, Tutnauer J, Hartman TE, Hwang S, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC*, and Yun J* "High-fructose corn syrup enhances intestinal tumor growth in mice." Science. 2019 : Pubmed PMID: 30898933
- CPRIT Scholar (09/01/2017 - 08/31/2021) Cancer Prevention Research Institute of Texas (CPRIT)
- Career Transition Award (K22) (03/01/2018 - 03/01/2020) National Cancer Institute
- V Scholar Award for Cancer Research (11/01/2019 - 11/01/2021) V Foundation
- Pew-Steward Scholar for Cancer Research (08/25/2020 - 08/22/2023) Pew Foundation
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