Gianfranco Spalletta, M.D.
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Gianfranco Spalletta, M.D.
Adjunct Associate Professor
Positions
- Adjunct Associate Professor
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Menninger Department of Psychiatry and Behavioral Sciences
Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry
Baylor College of Medicine
Houston, Texas United States
Addresses
- Medical Office Bldg-McNair (Office)
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Room: MMOB-E4.400
Houston, TX 77030
United States
gianfranco.spalletta@bcm.edu
- IRCCS Santa Lucia Foundation - Neuropsychiatry Laboratory (Lab)
-
Via Ardeatina, 306
Rome, TX 00179
United States
Phone: 390651501575
g.spalletta@hsantalucia.it
http://www.neuropsichiatrialab.com
Education
- MD from Sapienza University
- Rome, Italy Italy
- Residency at Tor Vergata University
- Rome, Italy
- Psychiatry
- PhD from Catholic University
- Rome, Italy
- Neuropsychology
Professional Interests
- Neuropsychiatry of Alzheimer's disease and Mild Cognitive Impairment
- Neuropsychiatry of Parkinson's disease
- Neuropsychiatry of stroke
- Cognitive deficits and associated brain structural abnormalities of schizophrenia
- Mechanisms of brain aging and subclinical neuropsychiatry phenomenology in healthy people
Websites
Selected Publications
- Di Paola M, Phillips O, Orfei MD, Piras F, Cacciari C, Caltagirone C, Spalletta G "Corpus Callosum Structure is Topographically Correlated with the Early Course of Cognition and Depression in Alzheimer's Disease." J Alzheimers Dis. 2015 February 3; : Pubmed PMID: 25649657
- Spalletta G, Piras F, Piras F, Sancesario G, Iorio M, Fratangeli C, Cacciari C, Caltagirone C, Orfei MD "Neuroanatomical correlates of awareness of illness in patients with amnestic mild cognitive impairment who will or will not convert to Alzheimer's disease." Cortex. 2014 December ; 61 : 183-195. Pubmed PMID: 25481475
- Pontieri FE, Assogna F, Pellicano C, Cacciari C, Pannunzi S, Morrone A, Danese E, Caltagirone C, Spalletta G "Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson׳s disease." Eur Neuropsychopharmacol. 2015 January ; 25 (1): 69-76. Pubmed PMID: 25435085
- Chiapponi C, Piras F, Fagioli S, Girardi P, Caltagirone C, Spalletta G "Hippocampus age-related microstructural changes in schizophrenia: a case-control mean diffusivity study." Schizophr Res. 2014 August ; 157 (1): 214-217. Pubmed PMID: 24924408
- Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H "Seroprevalence of autoantibodies against brain antigens in health and disease." Ann Neurol. 2014 July ; 76 (1): 82-94. Pubmed PMID: 24853231
- Spalletta G, Piras F, Piras F, Caltagirone C, Orfei MD "The structural neuroanatomy of metacognitive insight in schizophrenia and its psychopathological and neuropsychological correlates." Hum Brain Mapp. 2014 September ; 35 (9): 4729-4740. Pubmed PMID: 24700789
- Spalletta G, Robinson RG, Cravello L, Pontieri FE, Pierantozzi M, Stefani A, Long JD, Caltagirone C, Assogna F "The early course of affective and cognitive symptoms in de novo patients with Parkinson's disease." J Neurol. 2014 June ; 261 (6): 1126-1132. Pubmed PMID: 24695996
- Sannino S, Gozzi A, Cerasa A, Piras F, Scheggia D, Managò F, Damiano M, Galbusera A, Erickson LC, De Pietri Tonelli D, Bifone A, Tsaftaris SA, Caltagirone C, Weinberger DR, Spalletta G, Papaleo F "COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans." Cereb Cortex. 2014 March 21; : Pubmed PMID: 24658585
- Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L; E V O L U T I O N study Working Group "Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study." PLoS One. 2014 February 19; 9 (2): e89216. Pubmed PMID: 24586603
- Papiol S, Mitjans M, Assogna F, Piras F, Hammer C, Caltagirone C, Arias B, Ehrenreich H, Spalletta G "Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample. Transl Psychiatry." Transl Psychiatry. 2014 February 18; 4 : e362. Pubmed PMID: 24548877
- Spalletta G, Cravello L, Imperiale F, Salani F, Bossù P, Picchetto L, Cao M, Rasura M, Pazzelli F, Orzi F, Caltagirone C, Robinson RG, Cacciari C "Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke." J Neuropsychiatry Clin Neurosci. 2013 25 (4): 255-263. Pubmed PMID: 24247852
- Piras F, Piras F, Caltagirone C, Spalletta G "Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies." Neurosci Biobehav Rev. 2013 December ; 37 (10): 2856-2877. Pubmed PMID: 24177038
- Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, et al "Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity." Mol Psychiatry. 2014 October ; 19 (10): 1143-1149. Pubmed PMID: 23999527
- Spalletta G, Piras F, Caltagirone C, Fagioli S "Hippocampal multimodal structural changes and subclinical depression in healthy individuals." J Affect Disord. 2014 January ; 152 : 105-112. Pubmed PMID: 23800444
- Spalletta G, Fagioli S, Meco G, Pierantozzi M, Stefani A, Pisani V, Caltagirone C, Pontieri FE, Assogna F "Hedonic tone and its mood and cognitive correlates in Parkinson's disease." Depress Anxiety. 2013 January ; 30 (1): 85-91. Pubmed PMID: 23300113
- Laricchiuta D, Petrosini L, Piras F, Macci E, Cutuli D, Chiapponi C, Cerasa A, Picerni E, Caltagirone C, Girardi P, Tamorri SM, Spalletta G "Linking novelty seeking and harm avoidance personality traits to cerebellar volumes." Hum Brain Mapp. 2014 January ; 35 (1): 285-296. Pubmed PMID: 22965823
- Carlesimo GA, Piras F, Assogna F, Pontieri FE, Caltagirone C, Spalletta G "Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study." Neurology. 2012 June 12; 78 (24): 1934-1945. Pubmed PMID: 22649213
- Orfei MD, Piras F, Macci E, Caltagirone C, Spalletta G "The neuroanatomical correlates of cognitive insight in schizophrenia." Soc Cogn Affect Neurosci. 2013 April ; 8 (4): 418-423. Pubmed PMID: 22287264
- Assogna F, Palmer K, Pontieri FE, Pierantozzi M, Stefani A, Gianni W, Caltagirone C, Spalletta G "Alexithymia is a non-motor symptom of Parkinson disease." Am J Geriatr Psychiatry. 2012 February ; 20 (2): 133-141. Pubmed PMID: 22273734
- Assogna F, Cravello L, Caltagirone C, Spalletta G "Anhedonia in Parkinson's disease: a systematic review of the literature." Mov Disord. 2011 August 15; 26 (10): 1825-1834. Pubmed PMID: 21661052
- Adriano F, Caltagirone C, Spalletta G "Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis." Neuroscientist. 2012 April ; 18 (2): 180-200. Pubmed PMID: 21531988
- Donohoe G, Rose E, Frodl T, Morris D, Spoletini I, Adriano F, Bernardini S, Caltagirone C, Bossù P, Gill M, Corvin AP, Spalletta G "ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia." Neuroimage. 2011 February 1; 54 (3): 2132-2137. Pubmed PMID: 20934520
- Spoletini I, Piras F, Fagioli S, Rubino IA, Martinotti G, Siracusano A, Caltagirone C, Spalletta G "Suicidal attempts and increased right amygdala volume in schizophrenia." Schizophr Res. 2011 January ; 125 (1): 30-40. Pubmed PMID: 20869847
- Piras F, Caltagirone C, Spalletta G "Working memory performance and thalamus microstructure in healthy subjects." Neuroscience. 2010 December 1; 171 (2): 496-505. Pubmed PMID: 20850507
- Orfei MD, Varsi AE, Blundo C, Celia E, Casini AR, Caltagirone C, Spalletta G "Anosognosia in mild cognitive impairment and mild Alzheimer's disease: frequency and neuropsychological correlates." Am J Geriatr Psychiatry. 2010 December ; 18 (12): 1133-1140. Pubmed PMID: 20808100
- Spalletta G, Musicco M, Padovani A, Rozzini L, Perri R, Fadda L, Canonico V, Trequattrini A, Pettenati C, Caltagirone C, Palmer K "Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease." Am J Geriatr Psychiatry. 2010 November ; 18 (11): 1026-1035. Pubmed PMID: 20808086
- De Gennaro L, Cipolli C, Cherubini A, Assogna F, Cacciari C, Marzano C, Curcio G, Ferrara M, Caltagirone C, Spalletta G "Amygdala and hippocampus volumetry and diffusivity in relation to dreaming." Hum Brain Mapp. 2011 September ; 32 (9): 1458-1470. Pubmed PMID: 20740648
- éran P, Cherubini A, Assogna F, Piras F, Quattrocchi C, Peppe A, Celsis P, Rascol O, Démonet JF, Stefani A, Pierantozzi M, Pontieri FE, Caltagirone C, Spalletta G, Sabatini U "Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature." Brain. 2010 November ; 133 (11): 3423-3433. Pubmed PMID: 20736190
- Adriano F, Spoletini I, Caltagirone C, Spalletta G "Updated meta-analyses reveal thalamus volume reduction in patients with first-episode and chronic schizophrenia." Schizophr Res. 2010 October ; 123 (1): 1-14. Pubmed PMID: 20682456
- Robinson RG, Spalletta G "Poststroke depression: a review." Can J Psychiatry. 2010 June ; 55 (6): 341-349. Pubmed PMID: 20540828
- Di Paola M, Di Iulio F, Cherubini A, Blundo C, Casini AR, Sancesario G, Passafiume D, Caltagirone C, Spalletta G "When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study." Neurology. 2010 April 6; 74 (14): 1136-1142. Pubmed PMID: 20368633
- Di Iulio F, Palmer K, Blundo C, Casini AR, Gianni W, Caltagirone C, Spalletta G "Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes." Int Psychogeriatr. 2010 June ; 22 (4): 629-640. Pubmed PMID: 20367890
- Piras F, Cherubini A, Caltagirone C, Spalletta G "Education mediates microstructural changes in bilateral hippocampus." Hum Brain Mapp. 2011 February ; 32 (2): 282-289. Pubmed PMID: 20336658
- Cherubini A, Péran P, Spoletini I, Di Paola M, Di Iulio F, Hagberg GE, Sancesario G, Gianni W, Bossù P, Caltagirone C, Sabatini U, Spalletta G "Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patients." J Alzheimers Dis. 2010 19 (4): 1273-1282. Pubmed PMID: 20308792
- Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, Spalletta G "Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy." J Alzheimers Dis. 2010 20 (1): 175-183. Pubmed PMID: 20164594
- Carlesimo GA, Cherubini A, Caltagirone C, Spalletta G "Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study." Neurology. 2010 January 19; 74 (3): 194-200. Pubmed PMID: 20054010
- Donohoe G, Frodl T, Morris D, Spoletini I, Cannon DM, Cherubini A, Caltagirone C, Bossù P, McDonald C, Gill M, Corvin AP, Spalletta G "Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia." Neuropsychopharmacology. 2010 January ; 35 (2): 368-373. Pubmed PMID: 19794403
- Di Paola M, Luders E, Di Iulio F, Cherubini A, Passafiume D, Thompson PM, Caltagirone C, Toga AW, Spalletta G "Callosal atrophy in mild cognitive impairment and Alzheimer's disease: different effects in different stages." Neuroimage. 2010 January 1; 49 (1): 141-149. Pubmed PMID: 19643188
- Spoletini I, Cherubini A, Banfi G, Rubino IA, Peran P, Caltagirone C, Spalletta G "Hippocampi, thalami, and accumbens microstructural damage in schizophrenia: a volumetry, diffusivity, and neuropsychological study." Schizophr Bull. 2011 January ; 37 (1): 118-130. Pubmed PMID: 19542526
- Cherubini A, Spoletini I, Péran P, Luccichenti G, Di Paola M, Sancesario G, Gianni W, Giubilei F, Bossù P, Sabatini U, Caltagirone C, Spalletta G "A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients." Neurosci Lett. 2010 January 22; 469 (2): 214-218. Pubmed PMID: 19962428
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