Positions
- Associate Professor
-
Medicine-Immun, Allergy and Rheum
Baylor College of Medicine
Houston, TX US
Professional Interests
- Vaccines for substance abuse
Websites
Selected Publications
- Orson FM, Kinsey BM, Singh RA, Wu Y, Kosten TR "Vaccines for cocaine abuse.." 2009 Apr;5(4):194-9. Pubmed PMID: 19276665
- Shen XY, Orson FM, Kosten TR "Vaccines Against Drug Abuse.." Clin. Pharmacol. Ther. 2011 Nov 30 Pubmed PMID: 22130115
- Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S "The concept of pharmacologic cocaine interception as a treatment for drug abuse.." Chem. Biol. Interact. 2010 Sep 6;187(41277):421-4. Pubmed PMID: 20219449
- Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR "Substance abuse vaccines.." Ann. N. Y. Acad. Sci. 2008 Oct;1141:257-69. Pubmed PMID: 18991962
- Orson FM, Rossen RD, Shen X, Lopez AY, Wu Y, Kosten TR "Spontaneous Development of IgM Anti-Cocaine Antibodies in Habitual Cocaine Users: Effect on IgG Antibody Responses to a Cocaine Cholera Toxin B Conjugate Vaccine.." Am J Addict. 2013 Mar;22(2):169-74. Pubmed PMID: 23414504
- Orson FM, Kinsey BM, Densmore CL, Nguyen T, Wu Y, Mbawuike IN, Wyde PR "Protection against influenza infection by cytokine-enhanced aerosol genetic immunization.." J Gene Med. 2006 Apr;8(4):488-97. Pubmed PMID: 16389596
- Brimijoin S, Shen X, Orson F, Kosten T "Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.." Expert Rev Vaccines. 2013 Mar;12(3):323-32. Pubmed PMID: 23496671
- Ramakrishnan M, Alves De Melo F, Kinsey BM, Ladbury JE, Kosten TR, Orson FM "Probing cocaine-antibody interactions in buffer and human serum.." PLoS ONE. 2012;7(7):e40518. Pubmed PMID: 22859949
- Gao Y, Geng L, Orson F, Kinsey B, Kosten TR, Shen X, Brimijoin S "Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.." Chem. Biol. Interact. 2013 Mar 25;203(1):208-11. Pubmed PMID: 22935511
- Singh RA, Kosten TA, Kinsey BM, Shen X, Lopez AY, Kosten TR, Orson FM "Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion.." Pharmacol. Biochem. Behav. 2012 Dec;103(2):230-6. Pubmed PMID: 23010423
- Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S "Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.." PLoS ONE. 2012;7(8):e43536. Pubmed PMID: 22912888
- Martell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T, Kosten TR "Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.." Arch. Gen. Psychiatry. 2009 Oct;66(10):1116-23. Pubmed PMID: 19805702
- Kinsey BM, Jackson DC, Orson FM "Anti-drug vaccines to treat substance abuse.." Immunol. Cell Biol. ;87(4):309-14. Pubmed PMID: 19333250
- Kinsey BM, Kosten TR, Orson FM "Anti-cocaine vaccine development.." Expert Rev Vaccines. 2010 Sep;9(9):1109-14. Pubmed PMID: 20822352
- Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ, Gao Y "Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.." Chem. Biol. Interact. 2013 Mar 25;203(1):212-6. Pubmed PMID: 22960160
- Shen X, Orson FM, Kosten TR "Anti-addiction vaccines.." F1000 Med Rep. 2011;3:20. Pubmed PMID: 22003367
- Shen XY, Kosten TA, Lopez AY, Kinsey BM, Kosten TR, Orson FM "A vaccine against methamphetamine attenuates its behavioral effects in mice.." Drug Alcohol Depend. 2013 Apr 1;129(41276):41-8. Pubmed PMID: 23022610
Memberships
- AAI
- AAAAI
- ACP
Funding
- Cocaine Vaccine Development - #DA030338 NIDA
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