Email

david.murdock@bcm.edu

Positions

Assistant Professor

Mol. and Human Gen./B Lee Lab
Baylor College of Medicine

Assistant Director - Clinical Lab

Human Genome Sequencing Center
Baylor College of Medicine

Addresses

Adult Genetics Clinic (Clinic)

Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
(713) 798-7764
Adult Genetics Clinic

Education

BS from Rice University

Houston, Texas, United States

Bioengineering

MD from Baylor College of Medicine

Houston, Texas, United States

Postdoctoral Fellowship at Baylor College of Medicine

Houston, Texas, United States

Human Genome Sequencing Center

Residency at Louisiana State University Health Sciences Center

Shreveport, Louisiana, United States

Internal Medicine

Clinical Fellowship at the National Institutes of Health

Bethesda, Maryland, United States

Clinical Genetics, NIH-Johns Hopkins Consortium

Fellowship at the National Institutes of Health

Bethesda, Maryland, United States

Molecular Genetics

Certifications

Internal Medicine

American Board of Internal Medicine

Clinical Genetics

American Board of Medical Genetics and Genomics

Molecular Genetics

American Board of Medical Genetics and Genomics

Professional Interests

• Connective Tissue Disorders (Marfan, Loeys-Dietz, Ehlers-Danlos)
• Adult and Cardiovascular Genetics
• Xia-Gibbs syndrome
• Precision Medicine
• Bioinformatics

Professional Statement

My clinical and research interests involve connective tissue disorders such as Marfan syndrome and Loeys-Dietz syndrome, conditions that lead to aortic aneurysms and dissections. I am particularly interested in identifying new genes associated with such aortopathies and exploring the mechanisms of genetically-mediated aneurysm development. I also study Xia-Gibbs syndrome, a developmental disorder due to truncating mutations in the AHDC1 gene. The goal of these research efforts is to develop new therapies to improve outcomes. Among the tools I use are whole exome and genome sequencing as well as RNAseq.

As a member of the adult genetics team I diagnose and manage adults with a variety of genetic conditions (e.g., cancer). I am also the assistant director of the HGSC CAP/CLIA clinical lab where I perform analysis, interpretation, and reporting of sequencing data. I am committed to the growing field of personalized medicine through the eMERGE and BCM Cardiovascular Disease Genetics efforts. Lastly, I am dedicated to education and enjoy teaching about principles of genetics.

Selected Publications

• Jiang Y, Wangler MF, McGuire AL, Lupski JR, Posey JE, Khayat MM, Murdock DR, Sanchez-Pulido L, Ponting CP, Xia F, Hunter JV, Meng Q, Murugan M, Gibbs RA "The phenotypic spectrum of Xia-Gibbs syndrome." Am J Med Genet Part A. 2018 : Pubmed PMID: 29696776
• Murdock, DR, Donovan, FX, Chandrasekharappa, SC, Banks, N, Bondy, C, Muenke, M, Kruszka, P "Whole-exome Sequencing for Diagnosis of Turner Syndrome: Towards Next Generation Sequencing and Newborn Screening." J. Clin. Endocrinol. Metab. 2017 May 1; 102(5):1529-1537 : Pubmed PMID: 28324009
• Stokes, B, Berger, SI, Hall, BA, Weiss, K, Hadley, DW, Murdock, DR, Ramanathan, S, Clark, RD, Roessler, E, Kruszka, P, Muenke, M "SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly." Congenit Anom. 2018 January ; 58(1):29-32 : Pubmed PMID: 28670735
• Fleming, L, Lemmon, M, Beck, N, Johnson, M, Mu, W, Murdock, DR, Bodurtha, J, Hoover-Fong, J, Cohn, R, Bosemani, T, Barañano, K, Hamosh, A "Genotype-phenotype correlation of congenital anomalies in multiple congenital anomalies hypotonia seizures syndrome (MCAHS1)/PIGN-related epilepsy." Am. J. Med. Genet. A. 2016 January ; 170A(1):77-86 : Pubmed PMID: 26394714