David
Middle Name
R.
Murdock, M.D., F.A.C.M.G.
Middle Name
R.
Picture
Positions
- Assistant Professor
-
Mol. & Human Gen./B Lee Lab
Baylor College of Medicine
- Assistant Director - Clinical Lab
-
Human Genome Sequencing Center
Baylor College of Medicine
Addresses
- Adult Genetics Clinic (Clinic)
-
Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
(713) 798-7764
Adult Genetics Clinic
Education
- BS from Rice University
- Houston, Texas United States
- Bioengineering
- MD from Baylor College of Medicine
- Houston, Texas United States
- Postdoctoral Fellowship at Baylor College of Medicine
- Houston, Texas United States
- Human Genome Sequencing Center
- Residency at Louisiana State University Health Sciences Center
- Shreveport, Louisiana United States
- Internal Medicine
- Clinical Fellowship at the National Institutes of Health
- Bethesda, Maryland United States
- Clinical Genetics, NIH-Johns Hopkins Consortium
- Fellowship at the National Institutes of Health
- Bethesda, Maryland United States
- Molecular Genetics
Certifications
- Internal Medicine
- American Board of Internal Medicine
- Clinical Genetics
- American Board of Medical Genetics and Genomics
- Molecular Genetics
- American Board of Medical Genetics and Genomics
Professional Interests
- Connective Tissue Disorders (Marfan, Loeys-Dietz, Ehlers-Danlos)
- Adult and Cardiovascular Genetics
- Xia-Gibbs syndrome
- Precision Medicine
- Bioinformatics
Professional Statement
My clinical and research interests involve connective tissue disorders such as Marfan syndrome and Loeys-Dietz syndrome, conditions that lead to aortic aneurysms and dissections. I am particularly interested in identifying new genes associated with such aortopathies and exploring the mechanisms of genetically-mediated aneurysm development. I also study Xia-Gibbs syndrome, a developmental disorder due to truncating mutations in the AHDC1 gene. The goal of these research efforts is to develop new therapies to improve outcomes. Among the tools I use are whole exome and genome sequencing as well as RNAseq.As a member of the adult genetics team I diagnose and manage adults with a variety of genetic conditions (e.g., cancer). I am also the assistant director of the HGSC CAP/CLIA clinical lab where I perform analysis, interpretation, and reporting of sequencing data. I am committed to the growing field of personalized medicine through the eMERGE and BCM Cardiovascular Disease Genetics efforts. Lastly, I am dedicated to education and enjoy teaching about principles of genetics.
Selected Publications
- Jiang Y, Wangler MF, McGuire AL, Lupski JR, Posey JE, Khayat MM, Murdock DR, Sanchez-Pulido L, Ponting CP, Xia F, Hunter JV, Meng Q, Murugan M, Gibbs RA "The phenotypic spectrum of Xia-Gibbs syndrome." Am J Med Genet Part A. 2018 : Pubmed PMID: 29696776
- Murdock, DR, Donovan, FX, Chandrasekharappa, SC, Banks, N, Bondy, C, Muenke, M, Kruszka, P "Whole-exome Sequencing for Diagnosis of Turner Syndrome: Towards Next Generation Sequencing and Newborn Screening." J. Clin. Endocrinol. Metab. 2017 May 1; 102(5):1529-1537 : Pubmed PMID: 28324009
- Stokes, B, Berger, SI, Hall, BA, Weiss, K, Hadley, DW, Murdock, DR, Ramanathan, S, Clark, RD, Roessler, E, Kruszka, P, Muenke, M "SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly." Congenit Anom. 2018 January ; 58(1):29-32 : Pubmed PMID: 28670735
- Fleming, L, Lemmon, M, Beck, N, Johnson, M, Mu, W, Murdock, DR, Bodurtha, J, Hoover-Fong, J, Cohn, R, Bosemani, T, Barañano, K, Hamosh, A "Genotype-phenotype correlation of congenital anomalies in multiple congenital anomalies hypotonia seizures syndrome (MCAHS1)/PIGN-related epilepsy." Am. J. Med. Genet. A. 2016 January ; 170A(1):77-86 : Pubmed PMID: 26394714
- Carvalho, CMB, Zuccherato, LW, Williams, CL, Neill, NJ, Murdock, DR, Bainbridge, M, Jhangiani, SN, Muzny, DM, Gibbs, RA, Ip, W, Guillerman, RP, Lupski, JR, Bertuch, AA "Structural variation and missense mutation in SBDS associated with Shwachman-Diamond syndrome." BMC Med. Genet. 2014 June 4; 15:64 : Pubmed PMID: 24898207
- Hanchard, NA, Murdock, DR, Magoulas, PL, Bainbridge, M, Muzny, D, Wu, YQ, Wang, M, McGuire, AL, Lupski, JR, Gibbs, RA, Brown, CW "Exploring the utility of whole-exome sequencing as a diagnostic tool in a child with atypical episodic muscle weakness." Clin Genet. 2013 May ; 83(5):457-461 : Pubmed PMID: 22901280
- Campeau, PM, Kim, JC, Lu, JT, Schwartzentruber, JA, Abdul-Rahman, OA, Schlaubitz, S, Murdock, DR, et al "Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome." Am J Hum Genet. 2012 February 10; 90(2):282-9 : Pubmed PMID: 22265014
- Murdock, DR, Clark, GD, Bainbridge, MN, Newsham, I, Wu, Y-Q, Muzny, DM, Cheung, SW, Gibbs, RA, Ramocki, MB "Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria." Am. J. Med. Genet. A. 2011 September ; 155A(9):2071-7 : Pubmed PMID: 21834044
- Bainbridge, MN, Wiszniewski, W, Murdock, DR, Friedman, J, Gonzaga-Jauregui, C, Newsham, I, Reid, JG, Fink, JK, Morgan, MB, Gingras, M, Muzny, DM, Hoang, LD, Yousaf, S, Lupski, JR, Gibbs, RA "Whole-genome sequencing for optimized patient management." Sci. Transl. Med. 2011 June 15; 3(87) : Pubmed PMID: 21677200
- Murdock DR, Dai H, Burrage LC, Rosenfeld JA, Ketkar S, Müller MF, Yépez VA, Gagneur J, Liu P, Chen S, Jain M, Zapata G, Bacino CA, Chao HT, Moretti P, Craigen WJ, Hanchard NA, Lee B. "Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing." J Clin Invest. 2020 : Pubmed PMID: 33001864
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