Cinnamon
Middle Name
L.
Hardee
Middle Name
L.
Picture
Cinnamon
Middle Name
L.
Hardee
Middle Name
L.
Graduate Student, PhD Candidate
Positions
- Graduate Student, PhD Candidate
-
Integrative Molecular and Biomedical Sciences Graduate Program
Baylor College of Medicine
Houston, Texas United States
- Staff Research Associate III
-
Microbiology, Immunology & Molecular Genetics
University of California, Los Angeles
Los Angeles, California United States
- Research Specialist
-
Research Immunology/Bone Marrow Transplantation
Children's Hospital Los Angeles
Los Angeles, California United States
- Research Assistant
-
Research Immunology/Bone Marrow Transplantation
Children's Hospital Los Angeles
Los Angeles, California United States
Addresses
- Zechiedrich (Lab)
-
Department of Molecular Virology & Microbiology
Room: 220A
Houston, TX 77030
United States
Phone: (713) 798-5127
https://www.bcm.edu/research/labs/lynn-zechiedrich
Education
- BS from Univeristy of Southern California
- Los Angeles, California United States
- Biological Sciences, Psychology
Professional Interests
- Cell & Gene Therapy
- Immunotherapy
Professional Statement
I am currently a senior graduate student whose dissertation research focuses on the development of a non-viral gene therapy-based aerosol treatment strategy for both lung and systemic diseases. Our hope is to provide further treatment options for patients whose only options rely heavily on injection-based peptide administration (e.g. insulin). Progress in my research has generated important pre-clinical data needed to establish the feasibility of this approach, and will hopefully lead to therapies that are cheaper, less invasive, less frequent, and more convenient for patients in the future.Websites
Selected Publications
- "Effects of Vector Backbone and Pseudotype on Lentiviral Vector-Mediated Gene Transfer: Studies in Infant ADA-Deficient Mice and Rhesus Monkeys." 2014 : Pubmed PMID: 24925206
- "Modification of Hematopoietic Stem/Progenitor Cells with CD19-specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy." 2012 : Pubmed PMID: 23978226
- "Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells." 2012 : Pubmed PMID: 23380815
- "Regulated expansion of human pancreatic beta-cells." 2010 : Pubmed PMID: 20389286
- "Lentiviral vectors with amplified beta cell-specific gene expression." 2009 : Pubmed PMID: 19440227
- "CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model." 2008 : Pubmed PMID: 18606658
- "Advances in Non-Viral DNA Vectors for Gene Therapy." 2017 : Pubmed PMID: 28208635
- Lirio M Arévalo-Soliz, Cinnamon L Hardee, Jonathan M Fogg, Nathan R Corman, Cameron Noorbakhsh, Lynn Zechiedrich "Improving therapeutic potential of non-viral minimized DNA vectors." Cell Gene Ther Insights. 2020 November ; : 1489-1505. Pubmed PMID: 33953961
- Denise A Carbonaro-Sarracino, Alice F Tarantal, C Chang I Lee, Michael L Kaufman, Stephen Wandro, Xiangyang Jin, Michele Martinez, Danielle N Clark, Krista Chun, Colin Koziol, Cinnamon L Hardee, Xiaoyan Wang, Donald B Kohn "Dosing and re-administration of lentiviral vector for in vivo gene therapy in rhesus monkeys and ADA-deficient mice." Mol Ther Methods Clin Dev. 2020 March 13; 16 : 78-93. Pubmed PMID: 31871959
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