Jeffrey L. Neul, M.D., Ph.D.
Assistant Medical Director - Blue Bird Circle Rett Center
Jeffrey L. Neul, M.D., Ph.D.
6701 Fannin, CC 1250
Houston, TX 77030-2399
University of Chicago - M.D.
University of Chicago - Ph.D.
Current Positions in Professional Organizations
Member - Child Neurology Society
Member - American Neurological Association
Interested in translating knowledge acquired from basic science research into potential therapies for Rett syndrome. Actively using animal models of Rett syndrome to elucidate the pathophysiological mechanisms of disease and to conduct preclinical trials of potential therapies.
Current Research and Support
- Characterization of autonomic dysfunction in Rett syndrome and other MECP2 disorders. J. Neul, PI. NIH/NICHD. The goal of this project is to determine the neuroanatomic region in which MeCP2 function is required for normal lifespan and autonomic function.
- Molecular Pathogenic Studies of Rett Syndrome. H. Zoghbi, PI., J. Neul, Co-Investigator. NIH/NINDS. The goal of this project is to characterize the behavioral and molecular consequences of loss of MeCP2 function from specific neuronal populations. Co-Investigators' role: behavior analysis of conditional knock-out of MeCP2 function from neuronal populations.
- Characterization of cardiac abnormalities in Rett syndrome. J. Neul, PI. International Rett Syndrome Foundation - Research Grant #2462. The goal of this project is to define the relative contribution of the nervous system and the cardiomyocytes to the repolarization defect found both in people with Rett syndrome and in the animal model of Rett syndrome.
- Analysis of RO5046013 in a mouse model of Rett syndrome. J. Neul, PI. Roche. The goal of this project is to define the pharmokinetics and effects on lifespan of Roche compound RO5046013 in a mouse model of Rett syndrome.
- Philip R. Dodge Award. Child Neurology Society. J. Neul, Awardee. This award was given for work performed to date characterizing the role of the biogenic amines in a mouse model of Rett syndrome and the initial work characterizing HOXB1 CKO animals.
- Glaze DG, Percy AK, Skinner S, Motil KJ, Neul JL, Barrish JO, Lane JB, Geerts SP, Annese F, Graham J, McNair L, Lee HS. Epilepsy and the natural history of Rett syndrome. Neurology. 2010; 74(11):909-12.
- Percy AK, Lee HS, Neul JL, Lane JB, Skinner SA, Geerts SP, Annese F, Graham J, McNair L, Motil KJ, Barrish JO, Glaze DG. Profiling scoliosis in Rett syndrome. Pediatr Res. 2010; 67(4):435-9.
- Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A. 2009; 106(51):21966-71.
- Glaze DG, Percy AK, Motil KJ, Lane JB, Isaacs JS, Schultz RJ, Barrish JO, Neul JL, O'Brien WE, Smith EO. A study of the treatment of Rett syndrome with folate and betaine. J Child Neurol. 2009; 24(5):551-6.
- Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY. Deletion of Mecp2 in
Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron. 2008; 59(6):947-58.
- Neul JL, Fang P, Barrish J, Lane J, Caeg EB, Smith EO, Zoghbi H, Percy A, Glaze DG. Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome. Neurology. 2008; 70(16):1313-21.
- Samaco RC, Fryer JD, Ren J, Fyffe S, Chao HT, Sun Y, Greer JJ, Zoghbi HY, Neul JL. A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet. 2008; 17(12):1718-27.