Baylor College of Medicine

Low-carb diet may reduce risk of postmenopausal weight gain

Dipali Pathak


Houston, TX -

In an analysis of dietary patterns of postmenopausal women using data from the Women’s Health Initiative Observational Study, researchers at the USDA/ARS Children’s Nutrition Research Center at Baylor College of Medicine and Texas Children’s Hospital found that those who consumed the fewest carbohydrates had a significantly reduced risk of gaining 10 percent of their body weight over an eight-year period, whereas those who consumed the least fat had a significantly increased risk of gaining more than 10 percent of their body weight over that time period. Their report appeared this week in the British Journal of Nutrition.

Researchers analyzed four dietary patterns that are common in the general population to see which was predictive of a 10 percent weight gain over eight years: a diet that was low in fat compared to the rest of the population, a diet relatively low in carbohydrates, a Mediterranean-style diet and a diet that adhered to the Dietary Guidelines for Americans that is released by the U.S. Department of Agriculture and updated every five years.

Researchers used data from more than 93,000 women who were a part of the Women’s Health Initiative Observational Study. Their habitual diet was measured at baseline and at year three, and they self-reported their height and weight over the eight-year period. Researchers controlled for caloric intake and physical activity.

“We found that when we adjusted for some potential confounders such as socioeconomic status and age, people who ate the least fat, when we followed up with them eight years later, had a significantly increased risk of gaining more than 10 percent of their body weight, and the same pattern was seen for those following the Dietary Guidelines for Americans,” said Dr. Alexis C. Frazier-Wood, assistant professor of pediatrics at Baylor and the CNRC and senior author of the paper. “We saw no association with following a Mediterranean-style diet and risk of weight gain, and we found that those who ate the least carbohydrates had a significantly reduced risk of gaining 10 percent of their weight over an eight-year period.”

Frazier-Wood and the first author Dr. Christopher Ford did not look at other risk factors or outcomes such as cardiovascular disease or diabetes.

“This is a first step – I would not make recommendations for diet changes based on this study alone, but it is suggesting that too many carbohydrates in the diet are not helpful from the point of view of weight gain,” said Wood. “These data are in line with other emerging evidence, which collectively emphasize the need to consider carefully the dogma that reducing fat from the diet is helpful for obesity prevention.”

Frazier-Wood said that the next steps would be determining whether changes to someone’s diet changes their risk of weight gain, looking at why we see such an association and whether it is dependent on the type of carbohydrate or fat eaten, and then looking at other health outcomes, such as whether metabolic rates, glucose sensitivity and insulin sensitivity are different between the various diets.

Others who took part in the study include Christopher Ford, who is now at Emory University; Shine Chang with The University of Texas MD Anderson Cancer Center; Mara Z. Vitolins with Wake Forest School of Medicine; Jennifer I. Fenton with Michigan State University; Barbara V. Howard with Georgetown University Medical Center; Jinnie J. Rhee; Marcia Stefanick, Bertha Chen with Stanford School of Medicine; Linda Snetselaar with the University of Iowa College of Public Health and Rachel Urrutia with the University of North Carolina at Chapel Hill School of Medicine.

Funding for this study came from the National Institutes of Health, National Cancer Institute (5 R25 CA057730-24). The Women’s Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN26801100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C.

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