The Nuclear Receptor Signaling Atlas, a trans-National Institutes of Health project based at Baylor College of Medicine has received its third cycle of funding at $1.5 million annually for five years.

Over the past 10 years, NURSA has developed into a popular research resource for the nuclear receptor signaling community. During its existence, NURSA has attracted support from seven different NIH institutes, attesting to the cross-disciplinary nature of nuclear receptor and receptor co-regulator research and the importance of the site as a research resource. When the Eunice Kennedy Shriver National Institute of Child Health and Disease joins the consortium next year, annual funding is expected to increase to $1.65 million.

Principal investigators on the project are Dr. Bert W. O’Malley, chair of molecular and cellular biology at BCM and a founder of the project, Dr. Neil McKenna, assistant professor of molecular and cellular biology at BCM and Dr. Ronald Evans, professor and director of the Gene Expression Library at the Salk Institute for Biological Studies in La Jolla, Calif.

The NURSA website team is led by McKenna and Dr. Lauren Becnel, director of bioinformatics for the Dan L Duncan Cancer at BCM. The website,, contains reference Molecule Pages for accessing essential information on nuclear receptors, co-regulators and their ligands, a Datasets section for accessing data generated by NURSA Labs, and an Open Access MEDLINE-indexed journal, Nuclear Receptor Signaling.

The administrative and informatics component based at BCM has three main functions: 1) to continue to build web-based data analysis and visualization tools for the NURSA website 2) to manage a research funding program open for application by all members of the research community and 3) to make the data generated by this project available for free access to the worldwide community on the NURSA website.