Parkinson's Disease Research, Education and Clinical Center

Journal articles authored and co-authored by members of the Parkinson's Disease Research, Education and Clinical Center are listed here in reverse chronological order and grouped by published year. Click on the Expand plus symbol or Collapse minus symbol symbol to expand/collapse the list of journal publications by year, respectively.

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Journal Articles Published in 2023 (n = 2)

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Newsome MR, Martindale SL, Davenport N, Dennis EL, Diaz M, Esopenko C, et al. Subcortical functional connectivity and its association with walking performance following deployment related mild TBI. Front Neurol. 2023;14:1276437. PMID: 38156092.


Yusuff T, Chang YC, Sang TK, Jackson GR, Chatterjee S. Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD. Front Genet. 2023;14:881638. PMID: 36968586.


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Journal Articles Published in 2022 (n = 2)

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Shah C, Jackson GR, Sarwar AI, Mandava P, Jamal F. Treatment patterns in essential tremor: A retrospective analysis. Tremor Other Hyperkinet Mov (N Y). 2022;12:10. PMID: 35415009.


Troyanskaya M, Pastorek NJ, Jamal F, Jackson GR, Sarwar AI, Wilde EA, et al. A pilot study of olfactory function in veterans with a history of deployment-related mild traumatic brain injury. Neurocase. 2022;:1-8. PMID: 36576237.


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Journal Articles Published in <2021 (n = 86)

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Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Kent TA, et al. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Prog Neurobiol. 2020;184:101716. PMID: 31604111.


White DL, Kunik ME, Yu H, Lin HL, Richardson PA, Moore S, et al. Post-traumatic stress disorder is associated with further increased Parkinson's disease risk in veterans with traumatic brain injury. Ann Neurol. 2020;88(1):33-41. PMID: 32232880.


Chatterjee S, Ambegaokar SS, Jackson GR, Mudher A. Insulin-mediated changes in tau hyperphosphorylation and autophagy in a Drosophila model of tauopathy and neuroblastoma cells. Front Neurosci. 2019;13:801. PMID: 31427921.


Bryant MS, Workman CD, Jamal F, Meng H, Jackson GR. Feasibility study: Effect of hand resistance exercise on handwriting in Parkinson's disease and essential tremor. J Hand Ther. 2018;31(1):29-34. PMID: 28389133.


Jackson GR. Lifestyles of a toxic twosome: A novel tau strain induced by alpha-synuclein oligomers. Biol Psychiatry. 2018;84(7):472-3. PMID: 30176989.


Sarwar AI. Trazodone and parkinsonism: The link strengthens. Clin Neuropharmacol. 2018;41(3):106-8. PMID: 29634584.


Jackson GR. SCA31 flies perform in a balancing act between RAN translation and RNA-binding proteins. Neuron. 2017;94(1):4-5. PMID: 28384473.


Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, et al. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathol Commun. 2016;4(1):62. PMID: 27338814.


Iyer J, Wang Q, Le T, Pizzo L, Gronke S, Ambegaokar SS, et al. Quantitative assessment of eye phenotypes for functional genetic studies using Drosophila melanogaster. G3 (Bethesda). 2016;6(5):1427-37. PMID: 26994292.


Calleo JS, Amspoker AB, Sarwar AI, Kunik ME, Jankovic J, Marsh L, et al. A pilot study of a cognitive-behavioral treatment for anxiety and depression in patients with Parkinson disease. J Geriatr Psychiatry Neurol. 2015;28(3):210-7. PMID: 26047635.


Rothlind JC, York MK, Carlson K, Luo P, Marks WJ, Jr, et al. Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: Comparisons of treatment at pallidal and subthalamic targets versus best medical therapy. J Neurol Neurosurg Psychiatry. 2015;86(6):622-9. PMID: 25185211.


Sengupta U, Guerrero-Munoz MJ, Castillo-Carranza DL, Lasagna-Reeves CA, Gerson JE, Paulucci-Holthauzen AA, et al. Pathological Interface Between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies. Biol Psychiatry. 2015;78(10):672-83. PMID: 25676491.


Bakhoum MF, Bakhoum CY, Ding Z, Carlton SM, Campbell GA, Jackson GR. Evidence for autophagic gridlock in aging and neurodegeneration. Transl Res. 2014;164(1):1-12. PMID: 24561013.


Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34(12):4260-72. PMID: 24647946.


Choksi DK, Roy B, Chatterjee S, Yusuff T, Bakhoum MF, Sengupta U, et al. TDP-43 phosphorylation by casein kinase Iepsilon promotes oligomerization and enhances toxicity in vivo. Hum Mol Genet. 2014;23(4):1025-35. PMID: 24105464.


Guerrero-Munoz MJ, Castillo-Carranza DL, Krishnamurthy S, Paulucci-Holthauzen AA, Sengupta U, Lasagna-Reeves CA, et al. Amyloid-beta oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiol Dis. 2014;71:14-23. PMID: 25134727.


Jackson GR. Learn to forget: Regulation of age-related memory impairment by neuronal-glial crosstalk. Neuron. 2014;84(4):658-9. PMID: 25459404.


Mehanna R, Moore S, Hou JG, Sarwar AI, Lai EC. Comparing clinical features of young onset, middle onset and late onset Parkinson's disease. Parkinsonism Relat Disord. 2014;20(5):530-4. PMID: 24631501.


Patel AJ, Sarwar AI, Jankovic J, Viswanathan A. Bilateral pallidal deep brain stimulation for X-linked dystonia-parkinsonism. World Neurosurg. 2014;82(1-2):241 e1-4. PMID: 24076056.


Roy B, Jackson GR. Interactions between tau and alpha-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2014;23(11):3008-23. PMID: 24430504.


Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier). Alzheimers Dement. 2013;9(2):189-98. PMID: 23062850.


Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288(23):17042-50. PMID: 23632019.


Wightman PJ, Jackson GR, Dipple KM. Disruption of glycerol metabolism by RNAi targeting of genes encoding glycerol kinase results in a range of phenotype severity in Drosophila. PLoS One. 2013;8(9):e71664. PMID: 24039719.


Ambegaokar SS, Jackson GR. The downward spiral of tau and autolysosomes: a new hypothesis in neurodegeneration. Autophagy. 2012;8(7):1144-5. PMID: 22635052.


Hou JG, Wu LJ, Moore S, Ward C, York M, Atassi F, et al. Assessment of appropriate medication administration for hospitalized patients with Parkinson's disease. Parkinsonism Relat Disord. 2012;18(4):377-81. PMID: 22236581.


Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8(4):445-544. PMID: 22966490.


Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V, et al. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep. 2012;2:700. PMID: 23050084.


Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, et al. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. Faseb J. 2012;26(5):1946-59. PMID: 22253473.


Wightman PJ, Jackson GR, Dipple KM. Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. PLoS One. 2012;7(3):e31779. PMID: 22427807.


Ambegaokar SS, Jackson G. Double vision: Pigment genes do more than just color. Fly (Austin). 2011;5(3):206-9. PMID: 21406968.


Ambegaokar SS, Jackson GR. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet. 2011;20(24):4947-77. PMID: 21949350.


Bakhoum MF, Jackson GR. Demise of the flies: Why Drosophila models still matter. Prog Mol Biol Transl Sci. 2011;100:483-98. PMID: 21377634.


Chang YC, Hung WT, Chang HC, Wu CL, Chiang AS, Jackson GR, et al. Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLoS Genet. 2011;7(2):e1001288. PMID: 21304887.


Clos AL, Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Jackson GR, Kelly B, et al. Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis. Br J Dermatol. 2011;165(6):1349-54. PMID: 21729025.


Clos AL, Lasagna-Reeves CA, Kelly B, Wagner R, Wilkerson M, Jackson GR, et al. Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis. J Am Acad Dermatol. 2011;65(5):1023-31. PMID: 21669474.


Kayed R, Jackson GR, Estes DM, Barrett AD. Alzheimers disease: Review of emerging treatment role for intravenous immunoglobulins. J Cent Nerv Syst Dis. 2011;3:67-73. PMID: 23861639.


Lasagna-Reeves CA, Castillo-Carranza DL, Jackson GR, Kayed R. Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies. Curr Alzheimer Res. 2011;8(6):659-65. PMID: 21605039.


Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener. 2011;6:39. PMID: 21645391.


Ambegaokar SS, Jackson GR. Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster. Genetics. 2010;186(1):435-42. PMID: 20592261.


Ambegaokar SS, Roy B, Jackson GR. Neurodegenerative models in Drosophila: Polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis. Neurobiol Dis. 2010;40(1):29-39. PMID: 20561920.


Barrett AD, Kayed R, Jackson GR, Cunningham KA. New vaccine development for chronic brain disease. Neuropsychopharmacology. 2010;35(1):354. PMID: 20010720.


Clos AL, Lasagna-Reeves CA, Wagner R, Kelly B, Jackson GR, Kayed R. Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies. Exp Dermatol. 2010;19(10):904-11. PMID: 20626464.


Langbehn DR, Hayden MR, Paulsen JS, Predict-HD Investigators of the Huntington Study Group. CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(2):397-408. PMID: 19548255.


Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. 2010;49(47):10039-41. PMID: 21047142.


Lasagna-Reeves CA, Clos AL, Midoro-Hiriuti T, Goldblum RM, Jackson GR, Kayed R. Inhaled insulin forms toxic pulmonary amyloid aggregates. Endocrinology. 2010;151(10):4717-24. PMID: 20685871.


Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, et al. Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull. 2010;82(3-4):201-7. PMID: 20385209.


Quaid KA, Swenson MM, Sims SL, Harrison JM, Moskowitz C, Stepanov N, et al. What were you thinking? Individuals at risk for Huntington Disease talk about having children. J Genet Couns. 2010;19(6):606-17. PMID: 20734119.


Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, et al. Motor abnormalities in premanifest persons with Huntington's disease: The PREDICT-HD study. Mov Disord. 2009;24(12):1763-72. PMID: 19562761.


Chatterjee S, Sang TK, Lawless GM, Jackson GR. Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18(1):164-77. PMID: 18930955.


Kayed R, Jackson GR. Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders. Curr Opin Immunol. 2009;21(3):359-63. PMID: 19482462.


Kuo SH, Jackson GR. Emerging subspecialties in neurology: Translational research in movement disorders. Neurology. 2009;73(8):e40-1. PMID: 19704074.


Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, et al. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci. 2009;29(7):1962-76. PMID: 19228951.


Marder K, Zhao H, Eberly S, Tanner CM, Oakes D, Shoulson I, et al. Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants. Neurology. 2009;73(5):385-92. PMID: 19652143.


Jackson GR. Guide to understanding Drosophila models of neurodegenerative diseases. PLoS Biol. 2008;6(2):e53. PMID: 18303955.


Oster E, Dorsey ER, Bausch J, Shinaman A, Kayson E, Oakes D, et al. Fear of health insurance loss among individuals at risk for Huntington disease. Am J Med Genet A. 2008;146A(16):2070-7. PMID: 18627059.


Ratnaparkhi A, Lawless GM, Schweizer FE, Golshani P, Jackson GR. A Drosophila model of ALS: Human ALS-associated mutation in VAP33A suggests a dominant negative mechanism. PLoS One. 2008;3(6):e2334. PMID: 18523548.


Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, et al. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch Neurol. 2008;65(10):1368-74. PMID: 18852354.



Vanek Z, Sarwar A. Dystonia - A review of current concepts and their application in Pakistan. Pak J Neurol Sci. 2008;3(1):20-6.


Sang TK, Chang HY, Lawless GM, Ratnaparkhi A, Mee L, Ackerson LC, et al. A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. J Neurosci. 2007;27(5):981-92. PMID: 17267552.



Davis TL, Brodsky MA, Carter VA, DiFazio M, Frishberg B, Lai EC, et al. Consensus statement on the use of botulinum neuro-toxin to treat spasticity in adults. P&T. 2006;31(11):666-82.


Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, et al. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2006;50(3):359-75. PMID: 16675392.


Fogel B, Wu M, Kremen S, Murthy K, Jackson G, Vanek Z. Creutzfeldt-Jakob disease presenting with alien limb sign. Mov Disord. 2006;21(7):1040-2. PMID: 16552737.


Huntington Study Group PHAROS Investigators. At risk for Huntington disease: The PHAROS (Prospective Huntington At Risk Observational Study) cohort enrolled. Arch Neurol. 2006;63(7):991-6. PMID: 16831969.


Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, et al. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron. 2006;51(5):549-60. PMID: 16950154.


Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, et al. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006;45(50):15111-9. PMID: 17154549.


Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, et al. Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins. Proc Natl Acad Sci U S A. 2006;103(39):14367-72. PMID: 16980414.


Hogarth P, Kayson E, Kieburtz K, Marder K, Oakes D, Rosas D, et al. Interrater agreement in the assessment of motor manifestations of Huntington's disease. Mov Disord. 2005;20(3):293-7. PMID: 15584032.


Mee L, Honkala H, Kopra O, Vesa J, Finnila S, Visapaa I, et al. Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1. Hum Mol Genet. 2005;14(11):1475-88. PMID: 15843405.


Sang TK, Jackson GR. Drosophila models of neurodegenerative disease. NeuroRx. 2005;2(3):438-46. PMID: 16389307.


Sang TK, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, et al. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 2005;14(3):357-72. PMID: 15590702.


Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron. 2002;34(4):509-19. PMID: 12062036.


Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001;413(6857):739-43. PMID: 11607033.


Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, et al. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 1998;21(3):633-42. PMID: 9768849.


Pan Z, Sampath D, Jackson G, Werrbach-Perez K, Perez-Polo R. Nerve growth factor and oxidative stress in the nervous system. Adv Exp Med Biol. 1997;429:173-93. PMID: 9413574.


Jackson GR, Sampath D, Werrbach-Perez K, Perez-Polo JR. Effects of nerve growth factor on catalase and glutathione peroxidase in a hydrogen peroxide-resistant pheochromocytoma subclone. Brain Res. 1994;634(1):69-76. PMID: 8156393.


Jackson GR, Werrbach-Perez K, Pan Z, Sampath D, Perez-Polo JR. Neurotrophin regulation of energy homeostasis in the central nervous system. Dev Neurosci. 1994;16(5-6):285-90. PMID: 7768207.


Sampath D, Jackson GR, Werrbach-Perez K, Perez-Polo JR. Effects of nerve growth factor on glutathione peroxidase and catalase in PC12 cells. J Neurochem. 1994;62(6):2476-9. PMID: 8189251.


Foreman PJ, Taglialatela G, Jackson GR, Perez-Polo JR. Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells. J Neurosci Res. 1992;31(1):52-7. PMID: 1319504.


Jackson GR, Werrbach-Perez K, Ezell EL, Post JF, Perez-Polo JR. Nerve growth factor effects on pyridine nucleotides after oxidant injury of rat pheochromocytoma cells. Brain Res. 1992;592(1-2):239-48. PMID: 1450913.


Taglialatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, Jackson GR, Perez-Polo JR. Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol. 1992;44(3):577-85. PMID: 1324679.


Jackson GR, Morgan BC, Werrbach-Perez K, Perez-Polo JR. Antioxidant effect of retinoic acid on PC12 rat pheochromocytoma. Int J Dev Neurosci. 1991;9(2):161-70. PMID: 1647645.


Taglialatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, Jackson GR, Perez-Polo JR. Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor. Brain Res Dev Brain Res. 1991;59(2):221-30. PMID: 1655307.


Jackson GR, Apffel L, Werrbach-Perez K, Perez-Polo JR. Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance. J Neurosci Res. 1990;25(3):360-8. PMID: 2325161.


Jackson GR, Werrbach-Perez K, Perez-Polo JR. Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. II. A conditioning lesion paradigm. J Neurosci Res. 1990;25(3):369-74. PMID: 2325162.


Perez-Polo JR, Foreman PJ, Jackson GR, Shan D, Taglialatela G, Thorpe LW, et al. Nerve growth factor and neuronal cell death. Mol Neurobiol. 1990;4(1-2):57-91. PMID: 2076219.


Werrbach-Perez K, Jackson G, Marchetti D, Morgan B, Thorpe L, Perez-Polo JR. Growth factor-mediated protection in aging CNS. Prog Brain Res. 1990;86:183-94. PMID: 1965052.