Developmental Neurogenetics Laboratory
Click on the sign to list the poster and platform presentations by year. Then click on the link to view that presentation.
2022
- Encephalopathy in kv1.1 KO mice is associated with hippocampal BDNF and EGR3.
- Nonlinear dysregulation of glutamate and neural activity facilitates glioma-induced epilepsy.
- A digenic mechanism for absence epilepsy.
- Emx1-Cre is expressed in peripheral neurons that regulate cardiorespiratory tone.
- mTOR complexes in epilepsy and seizure disorders.
- Dissecting the role of mTOR complexes in epilepsy and seizure disorders.
- Layer- and cell type- specific cortical circuit deficits underlying the absence epilepsy.
- Transcriptional dysregulation of thalamic t-type calcium channel gene precedes seizure onset in childhood absence epilepsy mouse model tottering.
- Actigraphic correlates of psychiatric disability in patients with focal epilepsy.
American Epilepsy Society (AES)
76th Annual Meeting in Nashville, Tenn. (Dec. 2-6, 2022)
Society for Neuroscience (SFN)
52nd Annual Meeting in San Diego, Calif. (Nov. 12-16, 2022)
American Neurological Association (ANA)
147th Annual Meeting in Chicago, Ill. (Oct. 22-25, 2022)
2021
- Spontaneous cortical spreading depolarization in a SCN1A deficient Dravet syndrome mouse model.
- System xc: Friend or foe in KCNA1-null mice?
- On the mental status of Stargazer mice.
- Actigraphic correlates of disability in patients with focal epilepsy.
- On the digital psychopharmacology of antiseizure medications.
- Making absence epilepsy by combining two epilepsy genes.
- Fenfluramine directly inhibits cortical spreading depolarization&emdash;A pathophysiologic process linked to SUDEP.
- Transcriptional dysregulation of thalamic T-type calcium channel CACNA1G gene precedes seizure onset in childhood absence epilepsy mouse model tottering.
- Layer- and pathway-specific disruption of perisomatic inhibition in the somatosensory cortex of the stargazer model of absence epilepsy.
- The utility of additional depth or subdural electrodes following stereotactic EEG evaluation.
American Epilepsy Society (AES)
75th Annual Meeting in Chicago, Ill. (Dec. 3-7, 2021)
Society for Neuroscience (SFN)
Virtual Annual Meeting (Nov. 8-11, 2021)
American Clinical Neurophysiology Society (ACNS)
Virtual 2021 Annual Meeting (Feb. 10-14, 2021)
<2020
- Actigraphic correlates of disability in patients with focal epilepsy.
- Epileptic encephalopathy in KCNA1 KO mice disrupts active state organization.
- Deficits in 5-HT2C receptor signaling coordinately impact seizure risk and behavioral activity.
- On the digital psychopharmacology of valproic acid in mice: Adult and prenatal exposure.
- Epileptic encephalopathy in Kcna1 KO mice disrupts active state organization.
- Mice lacking 5-HT2C receptors have a lowered spreading depolarization threshold compared to wildtype littermates.
- Arx mouse model of x-linked infantile spasms shows augmented wave of early cortical apoptosis without evidence of cellular inflammation.
- Cav3.1 and 3.2 T-type Ca2+ channels collectively contribute to oscillatory excitation of nucleus ambiguus neurons.
- A genetic cross between Gad2-Cre and loxTB Htr2c mouse strains does not prevent seizures and death in a 5-HT2C-null SUDEP mouse model.
- Progression of cortical hypersynchrony and epileptogenesis induced by brain tumors.
[Platform Presentation]
- Mice with adult-onset P/Q calcium channel deletion recapitulates childhood absence epilepsy.
- Tau loss modifies network excitability in brain tumor-related epilepsy.
- Functional involvement of periventricular nodular heterotopia.
- An objective description of PTZ kindling in a standardized instrumented home cage environment.
- Home cage monitoring reveals the presence of comorbid depression-related behavior in mice with deletions of Kcna1.
- Mice lacking 5-HT2C receptors display a novel adult-onset SUDEP phenotype and increased mortality in males.
- Conditional deletion of PQ-type calcium channels in kainate receptor4 (Grik4)-expressing hippocampal neurons leads to adult onset absence epilepsy.
- Interictal dentate gyrus hyperexcitation in a mouse model of Dravet syndrome.
- Dysregulation of mTORC2, but not mTORC1, underlies the neurophysiological and behavior abnormalities in Pten-deficient mouse model of ASD and epilepsy.
- Tau loss modifies network excitability in brain tumor related epilepsy.
- β-spectrins maintain Na+ channels at axon initial segments and nodes of Ranvier.
- T-type calcium channel bursting in thalamic association pathways precedes sensory pathways and can be activated by GABAergic input during early postnatal development.
- Tau loss modifies network excitability in glioma-associated epilepsy.
- Evidence for brainstem network disruption in focal epilepsy and sudden unexplained death in epilepsy: A first validation study.
- mTORC2 dysfunction underlies the neuronal physiological and behavioral abnormalities in Pten-deficient mouse model of autism.
- Development of T-type calcium channel bursting in thalamic association pathway precedes sensory pathways.
- Adrenergic signaling promotes T-type Ca2+ channel mediated oscillatory discharges in nucleus ambiguus neurons.
- Clinical utility of genetic testing in adults with epilepsy: 4-year experience of the Baylor Genetic Epilepsy Clinic.
- Center for SUDEP Research: Brainstem atrophy in SUDEP.
- The role of tau in modulating hyper excitability in an emerging model of tumor associated epilepsy.
- Dynamics of gamma oscillations in a mouse model of absence epilepsy.
- Clinical utility of genetic testing in adults with epilepsy: Pilot experience of the Baylor genetic epilepsy clinic.
- Asynchronous suppression of superficial cortex during absence seizures.
[Platform Presentation]
- A critical developmental window for 17β-estradiol antiepileptogenic effect in a mouse model of X-linked infantile spasms.
- Characterization of a polysynaptic microcircuit involved in sensory vagal afferent activation of dorsomotor vagal neurons in mouse.
- The role of tau in modulating hyper-excitability in an emerging model of tumor associated epilepsy.
- αII-spectrin-dependent cytoskeletons are essential for axon function, domain assembly and integrity.
- Early development of thalamic low-threshold T-type calcium current in the VPM of C57BL/6 mice.
- A critical developmental window for 17β-estradiol antiepileptogenic effect in a mouse model of X-linked infantile spasms.
- Prevalence and character of severe epileptic encephalopathy in patients affected by MECP2 duplication syndrome.
- Dynamic participation patterns of superficial cortex during absence seizures.
- Polysynaptic activation of dorsomotor vagal neurons by sensory afferent nerve.
- Severe epileptic encephalopathy is a frequent neurological comorbidity of children affected by the MECP2 duplication syndrome.
[Oral Presentation]
- Leaky ryanodine receptor-2 mutation lowers threshold for hypoxic spreading depolarization.
- Interictal relative gamma power as a biomarker for anti-epileptic drug response in absence epilepsy.
- MECP2 duplication is associated with severe epileptic encephalopathy in the presence of permissive genetic background.
- A critical developmental window for 17β-estradiol anti-epileptogenic effect in a mouse model of x-linked infantile spasms.
- Cardiac arrhythmogenic leaky ryanodine receptor 2 mutation increases cortical excitability and lowers threshold for spreading depolarization in mouse brain.
- Neonatal estradiol prevents infantile spasms and seizures in arx-linked infantile spasms syndrome.
[Platform Presentation]
- Treatment resistance correlates with ECG abnormalities in a pilot clinical surveillance of epilepsy patients.
- Increased risk of hypoxic depolarization of the brainstem autonomic circuit in a mouse SUDEP model.
- Lateralization of temporal lobe epilepsy with long-term ambulatory intracranial monitoring using the RNS system: Experience in 82 patients.
- STOP SUDEP Program: Application of visual automated fluorescence electrophoresis in the qualitative profiling of archived SUDEP samples.
- In vivo 2-photon confocal microscopy of cortical absence epilepsy.
- Bexarotene decreases hyperexcitability in two mouse models with epilepsy.
- Genetic ablation of betaII-spectrin in the central nervous system results in axon degeneration, epilepsy and postnatal lethality.
- Sudden unexplained death in epilepsy: Can genomics help?
[Plenary Talk]
- SUDEP Tissue Donation Program (STOP): Collaborative network in support of SUDEP registry, tissue repository and human translational research.
- Universal DNA extraction protocol for the utilization of alternative tissue sources in downstream epilepsy genetic analysis.
- SUDEP research consortium: A new collaborative network to discover predictive genes, mechanisms and biomarkers of SUDEP.
[Investigators' Workshop]
- Loss of tau protein reduces hyperexcitability in mouse and drosophila genetic models of epilepsy.
- Myotonia in brain: 'Skeletal' chloride channel ClC-1 linked to idiopathic generalized epilepsy with focal myotonia.
- Channotyping epilepsy: Profiling personal variation in ion channel genes.
- 17?-estradiol decreases seizure and interictal spike frequency in a genetic mouse model of X-linked infantile spasms.
- Neuronal Elavl proteins regulate RNA splicing and abundance to control brain glutaminase expression and neuronal excitability.
- Intracellular dialysis can be exploited to distinguish sources of intracellular Zn2+ accumulation in hippocampal neurons.
- Dendritic AMPA receptor deficit on cortical interneurons in the stargazer mouse model of absence epilepsy.
- NMDA receptor activation prolongs the duration of ionic dyshomeostasis following spreading depolarization in murine brain slices.
- Propagation of spreading depolarizations is limited by the synaptic release and extracellular actions of Zn2+.
- Flupirtine reverses hyperexcitability in Kv1.1 potassium channel deficient myelinated vagal axons.
- Tau loss regulates excitability in mouse and Drosophila genetic models of epilepsy.
- ADAM11 is responsible for trafficking of Kv1 subunits to cerebellar basket cell terminals.
- Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia.
- Early 17-beta-estradiol treatment decreases seizure and interictal spike frequency in the ARX(GCG)10+7 genetic mouse model of X-linked infantile spasms.
- Suppression of the protein kinase PKR promotes network hypersynchrony and enhanced cognition.
- NMDA-R activation contributes to metabolic burden following spreading depolarization in murine hippocampal slices.
- Coding and decoding pathogenic ion channels in epilepsy.
- High resolution copy number variation of ion channel genes in epilepsy.
- Metabolic dependence of zinc effects on spreading depression in murine brain slices.
- MeCP2 deficiency in GABAergic neurons recapitulates Rett syndrome phenotypes.
- Different roles of extracellular and intracellular Zn2+ in spreading depression-like events in hippocampal slice.
- Spontaneous epilepsy and neuronal hyperexcitability in Kv12.2 -/- mice.
- Long QT mouse model links the dual phenotype of cardiac arrhythmias and epilepsy with sudden unexplained death in epilepsy.
- MeCP2 regulation of GABAergic neuronal function modulates behavior and synaptic plasticity.
- MeCP2 regulation of GABAergic neuronal function modulates behavior and synaptic plasticity.
- Non-convulsive seizure phenotypes and dementia in mice and humans.
- Spontaneous epilepsy and neuronal hyperexcitability in Kv12.2 -/- mice.
- Human KvLQT1 mutations in mice link the dual phenotype of cardiac arrhythmias and epilepsy with sudden unexplained death in epilepsy.
- Summary of the U.S. National Institute of Neurological Disorders and Stroke (NINDS)
Workshop on SUDEP.
- Kcna1 is a novel candidate gene for sudden unexplained death in epilepsy (SUDEP).
- Kcna1 is a novel candidate gene for sudden unexplained death in epilepsy (SUDEP).
- Growth curve analysis of changes in spatial and verbal learning characteristics after anterior temporal lobectomy.
- Masking epilepsy by combining two epilepsy mutations.
- Genomic research in the era of identifiable genetic information.
- Varied roles of BK-type potassium channels in the regulation of neuronal excitability: Which are important for epilepsy?
- Expression profile of voltage-gated sodium channel genes in two knockout mouse models exhibiting spontaneous seizures.
- Development of a transgenic mouse model of spike-wave epilepsy by overexpression of α1G T-type calcium channels.
- The prevalence of inter-ictal cardiac arrhythmias and LQT gene variants in patients with idiopathic epilepsy.
- Ion channel gene interactions in inherited epilepsy.
- Absence of mossy fibers in NeuroD/BETA2 null mice prevents pilocarpine-induced status epilepticus.
- Secretion and functional analysis of LGI/Epitempin family members.
- Regional and developmental localization of ion-channel genes coexpressed in heart and brain.
- Expression of apoptosis inhibitor protein MCL1 linked to neuroprotection in CNS neurons.
- Presidential symposium: The developing epileptic brain.
- Elevated T-type calcium currents in thalamic neurons are associated with spike-wave seizure generation in the mouse mutant Coloboma (Cm/+).
- Expression pattern of candidate epilepsy ion channel genes in mouse and human brains.
- EEG abnormalities and epilepsy in Smith-Magenis syndrome and in a genetic mouse model.
- The effect of topiramate on excitatory synaptic transmission in mouse hippocampus.
- Magnetoencephalography mislocalizes interictal epileptogenic activity in mesial temporal epilepsy.
- Differential early expression of novel genes in the hippocampus after pilocarpine-induced status epilepticus in inbred mouse strains with high and low seizure susceptibility.
- Increased calcium currents in thalamocortical relay cells of tottering and lethargic mice.
- Genetic aggregation of calcium channel defects in mice simulates non-Mendelian inherited human epilepsy.
- Expression of a family of calcium channel γ-subunits (CACNG 1-8) in mice.
- Absence of pilocarpine-induced status epilepticus in NeuroD knock out mice.
- Changes in presynaptic Ca currents and transmitter release are synapse-dependent in epileptic mice with calcium channel mutations.
- Altered calcium currents in thalamocortical relay cells of stargazer, a mouse epilepsy model caused by a calcium channel gamma sub-unit mutation.
- Mutation of the voltage-dependent calcium channel beta subunit gene Cchb4 is associated with absence seizures and ataxia in the lethargic (lh) mouse.
- A mutation in the sodium/hydrogen exchanger-1 gene causes ataxia and epilepsy in the slow-wave epilepsy mutant mouse.
- Subtype-specific downregulation of glutamate transporter gene expression in three models of temporal lobe epilepsy.
American Epilepsy Society (AES)
74th Annual Meeting in Seattle, Wash. (Dec. 4-8, 2020)
American Neurological Association (ANA)
145th Annual Meeting in Los Angeles, Calif. (Oct. 4-6, 2020)
American Epilepsy Society (AES)
73rd Annual Meeting in Baltimore, Md. (Dec. 6-10, 2019)
Society for Neuroscience (SFN)
49th Annual Meeting in Chicago, Ill. (Oct. 19-23, 2019)
American Epilepsy Society (AES)
72nd Annual Meeting in New Orleans, La. (Nov. 30 - Dec. 4, 2018)
Society for Neuroscience (SFN)
48th Annual Meeting in San Diego, Calif. (Nov. 3-7, 2018)
American Epilepsy Society (AES)
71st Annual Meeting in Washington, DC (Dec. 1-5, 2017)
Society for Neuroscience (SFN)
47th Annual Meeting in Washington, DC (Nov. 11-15, 2017)
American Neurological Association (ANA)
142nd Annual Meeting in San Diego, Calif. (Oct. 15-17, 2017)
American Epilepsy Society (AES)
70th Annual Meeting in Houston, Texas (Dec. 2-6, 2016)
Society for Neuroscience (SFN)
46th Annual Meeting in San Diego, Calif. (Nov. 12-16, 2016)
American Neurological Association (ANA)
141st Annual Meeting in Baltimore, Md. (Oct. 16-18, 2016)
Federation of American Societies for Experimental Biology (FASEB)
Science Research Conference (Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies) in Saxtons River, Vt. (July 17-22, 2016)
American Academy of Neurology (AAN)
68th Annual Meeting in Vancouver, BC, Canada (April 15-21, 2016)
American Epilepsy Society (AES)
69th Annual Meeting in Philadelphia, Penn. (Dec. 4-8, 2015)
Society for Neuroscience (SFN)
45th Annual Meeting in Chicago, Ill. (Oct. 17-21, 2015)
31st International Epilepsy Congress (IEC)
Istanbul, Turkey (Sept. 5-9, 2015)
American Epilepsy Society (AES)
68th Annual Meeting in Seattle, Wash. (Dec. 5-9, 2014)
Society for Neuroscience (SFN)
44th Annual Meeting in Washington, DC (Nov. 15-19, 2014)
American Academy of Neurology (AAN)
66th Annual Meeting in Philadelphia, Penn. (April 26 - May 3, 2014)
American Epilepsy Society (AES)
67th Annual Meeting in Washington, DC (Dec. 6-10, 2013)
Society for Neuroscience (SFN)
43rd Annual Meeting in San Diego, Calif. (Nov. 9-13, 2013)
American Neurological Association (ANA)
138th Annual Meeting in New Orleans, La. (Oct. 13-15, 2013)
Alzheimer's Association, Houston and Southeast Texas Chapter
7th Annual Research Symposium on Alzheimer's Disease (Sept. 12, 2013)
American Epilepsy Society (AES)
66th Annual Meeting in San Diego, Calif. (Nov. 30 - Dec. 4, 2012)
Society for Neuroscience (SFN)
42nd Annual Meeting in New Orleans, La. (Oct. 13-17, 2012)
2011 International Society for Zinc Biology (ISZB)
Meeting in Melbourne, Australia (Jan. 15-19, 2012)
American Epilepsy Society (AES)
65th Annual Meeting in Baltimore, Md. (Dec. 2-6, 2011)
Society for Neuroscience (SFN)
41st Annual Meeting in Washington, DC (Nov. 12-16, 2011)
Gordon Research Conferences (GRC)
Excitatory Synapses & Brain Function Meeting in Easton, Mass. (June 26 - July 1, 2011)
American Academy of Neurology (AAN)
63rd Annual Meeting in Honolulu, Hawaii (April 9-16, 2011)
American Epilepsy Society (AES)
64th Annual Meeting in San Antonio, Texas (Dec. 3-7, 2010)
Society for Neuroscience (SFN)
40th Annual Meeting in San Diego, Calif. (Nov. 13-17, 2010)
American Society for Neurochemistry (ASN)
41st Annual Meeting in Santa Fe, N.M. (March 6-10, 2010)
Baylor College of Medicine (BCM)
20th Annual Rush and Helen Record Neuroscience Forum in Galveston, Texas (Feb. 19-21, 2010)
American Epilepsy Society (AES)
63rd Annual Meeting in Boston, Mass. (Dec. 4-8, 2009)
Society for Neuroscience (SFN)
39th Annual Meeting in Chicago, Ill. (Oct. 17-21, 2009)
28th International Epilepsy Congress (IEC)
Budapest, Hungary (June 29 - July 2, 2009)
American Epilepsy Society (AES)
62nd Annual Meeting in Seattle, Wash. (Dec. 5-9, 2008)
Society for Neuroscience (SFN)
38th Annual Meeting in Washington, DC (Nov. 15-19, 2008)
Mechanisms of Epilepsy and Neuronal Synchronization
Gordon Research Conference in Waterville, Maine (Aug. 3-8, 2008)
American Epilepsy Society (AES)
61st Annual Meeting in Philadelphia, Penn. (Nov. 30 - Dec. 4, 2007)
American Epilepsy Society (AES)
60th Annual Meeting in San Diego, Calif. (Dec. 1-5, 2006)
Mechanisms of Epilepsy and Neuronal Synchronization
Gordon Research Conference in Waterville, Maine (Aug. 6-11, 2006)
American Epilepsy Society (AES)
58th Annual Meeting in New Orleans, La. (Dec. 3-7, 2004)
American Epilepsy Society (AES)
57th Annual Meeting in Boston, Mass. (Dec. 5-10, 2003)
25th International Epilepsy Congress (IEC)
Lisbon, Portugal (Oct. 12-16, 2003)
American Epilepsy Society (AES)
56th Annual Meeting in Seattle, Wash. (Dec. 6-11, 2002)
American Epilepsy Society (AES)
55th Annual Meeting in Philadelphia, Penn. (Nov. 30 - Dec. 5, 2001)
American Epilepsy Society (AES)
54th Annual Meeting in Los Angeles, Calif. (Dec. 1-6, 2000)
American Epilepsy Society (AES)
51st Annual Meeting in Boston, Mass. (Dec. 7-10, 1997)