Neurocritical Care Research Conference

September 4 – 6, 2009

Denton A. Cooley Auditorium
Texas Heart Institute
St. Luke's Episcopal Hospital
6770 Bertner
Houston, Texas 77030

Welcome

It is a great pleasure to welcome you to this the First Neurocritical Research Conference and to Houston. The field of neurocritical care is rapidly maturing into a major player in clinical medicine. This discipline has evolved from a primary focus on the post-operative care of neurosurgical patients to the broader resuscitation of patients with massive brain insults. This conference intends to bridge the gap between the daily clinical care and the research ideas that will promote improved outcomes. The overall goal of this interdisciplinary scientific symposium is to bring together scientists and physicians from diverse fields with a common interest in understanding and advancing research in neurocritical care. The symposium is unique in that it will provide a forum for presenting and discussing the latest advances in clinical trial design, research tools, and research priorities in the field of neurocritical care. The need for the creation of a neurocritical care research network will also be addressed to facilitate collaboration and patient enrollment in clinical trials. Funding has been provided by NINDS (1R13NS065494-01, P.I. JI Suarez), St. Luke's Episcopal Hospital in Houston, and the Integra Foundation.

At the conclusion of this program, participants will be able to: 1) understand the importance and opportunities for research in neurocritical care diseases; 2) discuss recent scientific advances related to clinical trial design and research tools that will have an impact on neurocritical care research; 3) determine the future directions of research of neurocritical care diseases; and 4) establish a collaborative network in neurocritical care research.

We are very excited to have you here with us. Your participation will be vital to the overall success of this symposium. We strongly encourage you to actively participate in all the interactive sessions. We will be videotaping the entire meeting and its content will be posted in the Neurocritical Care Society website for public view as soon as technically feasible. In addition the Organizing Committee and the invited speakers have prepared draft summary statements of the topics to be discussed with the goal of editing their contents during breakout discussions at the end of each session. The final manuscripts will be published in Neurocritical Care.

Jose I. Suarez, M.D.
Chair on behalf of the Organizing Committee

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Speakers and Planning Committee

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Organizing Committee

Dr. Jose I. Suarez

Jose I. Suarez, M.D.

Associate Professor of Neurology
Baylor College of Medicine
Houston, TX

 Eusebia Calvillo, R.N.

Eusebia Calvillo, R.N.

Research Coordinator
Baylor College of Medicine
Houston, TX

 Connie Boyd, R.N.

Connie Boyd, R.N.

Director, Neuroscience Service Line

St. Luke's Episcopal Hospital
Houston, TX

 Sarah Livesay, R.N., M.S.N., C.N.S., A.C.N.P.

Sarah Livesay, R.N., M.S.N., C.N.S., A.C.N.P.

Manager, Neuroscience Program

St. Luke's Episcopal Hospital
Houston, TX

Janet Lipnick

Janet Lipnick

CME Coordinator

St. Luke's Episcopal Hospital
Houston, TX

Yajaira Garza

Yajaira Garza

Administrative Assistant

St. Luke's Episcopal Hospital
Houston, TX

Dr. Christiana Hall

Christiana Hall, M.D.

Assistant Professor of Neurology
UT Southwestern
Dallas, TX

Dr. Christine Wijman

Christine Wijman, M.D.

Associate Professor of Neurology
and Neurological Sciences
Stanford University
Palo Alto, CA

Dr. Romergryko Geocadin

Romergryko Geocadin, M.D.

Associate Professor of Neurology, Neurosurgery, and Anesthesiology & Critical Care Medicine
Johns Hopkins University
Baltimore, MD

Dr. Peter D. LeRoux

Peter D. LeRoux, M.D.

Associate Professor of Neurosurgery
University of Pennsylvania
Philadelphia, PA

Dr. Sam O. Zaidat

Sam O. Zaidat, M.D.

Associate Professor of Neurology
and Neurosurgery
Medical College of Wisconsin
Milwaukee, WI

Dr. Stephan A. Mayer

Stephan A. Mayer, M.D.

Professor of Clinical Neurology
and Neurological Surgery
Columbia University
New York, NY

Dr. Paul Vespa

Paul Vespa, M.D.

Associate Professor of Neurosurgery
and Neurology
University of California, Los Angeles

   

Travel Fellowship Committee

Wendy Ziai, M.D.

Assistant Professor of Neurology, Neurosurgery,
and Anesthesiology and Critical Care Medicine
Johns Hopkins University
Baltimore, M.D.

Carmelo Graffagnino, M.D.

Associate Professor of Medicine and Neurology
Duke University
Durham, NC

Jennifer Frontera, M.D.

Assistant Professor of Neurology and Neurosurgery
Mt. Sinai School of Medicine
New York, NY

Speakers

Thomas P. Bleck, M.D.

Professor of Neurology, Neurosurgery,
Pulmonary & Critical Care Medicine, and Anesthesiology
Rush Medical College
Chicago, IL

Cherylee Chang, M.D.

Associate Clinical Professor of Neurology
University of Hawaii
Honolulu, HI

Jamie Cooper, M.D.

Professor and Deputy Director ICU
Monash University & Alfred Hospital
Melbourne, Australia

Janice Daly, Ph.D.

Associate Professor of Neurology
Case Western Reserve University
Cleveland, OH

Pramod Dash, Ph.D.

Professor of Neurobiology and Anatomy
University of Texas
Houston, TX

Michael Diringer, M.D.

Professor of Neurology and Neurosurgery
Washington University
St Louis, MO

Kalpalatha K. Guntupalli, M.D.

Professor of Medicine and Chief
Pulmonary, Critical Care, and Sleep Medicine Section
ARDSNET
Baylor College of Medicine
Houston, TX

Daniel F. Hanley, M.D.

Professor of Neurology, Neurosurgery,
and Anesthesiology & Critical Care Medicine
Johns Hopkins University
Baltimore, MD

Claude Hemphill, M.D., Ph.D.

Director, San Francisco General Hospital
Neurocritical Care Service
University of California, San Francisco

Walter Koroshetz, M.D.

Deputy Director, NINDS
Bethesda, MD

Marek Mirski, M.D., Ph.D.

Professor of Anesthesiology & Critical Care Medicine, Neurology, and Neurosurgery
Johns Hopkins University
Baltimore, MD

Yuko Palesch, Ph.D.

Professor of Biostatistics, Bioinformatics and Epidemiology
Medical University of South Carolina
Charleston, SC

Adnan I. Qureshi, M.D.

Professor of Neurology, Neurosurgery and Radiology
University of Minnesota
Minneapolis, MN

Claudia Robertson, M.D.

Professor of Neurosurgery
Baylor College of Medicine
Houston, TX

Robert Silbergleit, M.D.

Associate Professor of Emergency Medicine
NETT
University of Michigan
Ann Arbor, MI

Stelios Smirnakis, M.D., Ph.D.

Assistant Professor of Neurology and Neuroscience
Baylor College of Medicine
Houston, TX

Kinga Szigeti, M.D., Ph.D.

Assistant Professor of Neurology
Baylor College of Medicine
Houston, TX

Conference Schedule

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Friday, Sept. 4, 2009

6:00 p.m.

Speaker Registration

 

6:30

Welcoming Dinner and Reception
Opening Remarks

Jose I. Suarez, M.D., BCM
Walter Koroshetz, M.D., NINDS
David J. Fine, President & CEO, St. Luke's Episcopal Hospital

9:00

Session Ends

 

Saturday, Sept. 5, 2009

7:30 a.m.

Registration and Breakfast

 

8:30

Current Status of Neurocritical Care as a Clinical Discipline

Claude Hemphill, M.D., Ph.D.

9:00

The Future of Neurocritical Care

Cherylee Chang, M.D.

9:30

Coffee Break

 

Clinical Trial Design in the Neurocritical Care Unit ^

Moderator: Christiana Hall, M.D.

9:45

Endpoints and Surrogate Endpoints

Marek A. Mirski, M.D., Ph.D.

10:15

Outcome Measures: Dichotomize or Not

Yuko Palesch, Ph.D.

10:45

NIH Funding: Advantages and Disadvantages

Michael Diringer, M.D.

11:15

Industry Funding: Advantages and Disadvantages

Adnan I. Qureshi, M.D.

11:45

Waiver of Consent and Clinical Trials

Claudia Robertson, M.D.

12:15 p.m.

Questions for Presenters and Discussion

 

1:00

Lunch Break

 

Research and Technology in Neurocritical Care ^

Moderator: Christine Wijman, M.D. and Stelios Smirnakis, M.D., Ph.D.

2:00

Genomics: Deciphering Gene Association Studies in Critical Care

Kinga Szigeti, M.D., Ph.D.

2:30

Proteomic Analysis in Neurocritical Care

Pramod Dash, Ph.D.

3:15

Biomarkers of Primary and Enduring Brain Damage

Daniel F, Hanley, M.D.

3:45

Advances in Neuroimaging

Stelios Smirnakis, M.D., Ph.D.

4:15

Continuous Multi-Modality Neuromonitoring

Paul Vespa, M.D.

4:45

Questions for Presenters and Discussion

 

5:15

Coffee Break

 

The Critical Care Research Networks Experience ^

Moderator: Peter Leroux, M.D.

5:30

The Australian Experience

Jamie Cooper, M.D.

6:00

The ARDSNET Experience

Kalpalatha K. Guntupalli, M.D.

6:30

The NETT Experience

Robert Silbergleit, M.D.

7:00

Role of Rehabilitation in Neurocritical Care Research

Janice Daly, Ph.D.

7:30

Questions for Presenters and Discussion

 

8:15

Dinner

 

10:00

Session Ends

 

 

Sunday, Sept. 6, 2009

7:30 a.m.

Registration and Breakfast

 

Research Priorities in Neurocritical Care ^

Moderator: Romergryko Geocadin, M.D.

8:30

Insights from a TBI Researcher

Claudia Robertson, M.D.

9:00

Insights from an Experienced Neurointensivist

Thomas P. Bleck, M.D.

9:30

Do We Need Patient Registries?

Osama O. Zaidat, M.D.

10:00

Neurocritical Care Research Network: NINDS Viewpoint

Walter Koroshetz, M.D.

10:30

Questions for Presenters and Discussion

 

11:45

Concluding Remarks

Jose I. Suarez, M.D. and All Attendees

Noon

Meeting Adjourns

^ Presenters and moderators will have a 1-hour breakout session to refine summary statements and ideas following their presentation.

 

Continuing Medical Education

St. Luke's Episcopal Hospital is accredited by the Texas Medical Association to provide continuing medical education for physicians. St. Luke's designates this educational activity for a maximum of 12 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Sponsors

St. Luke's NeuroScience CenterDepartment of Neurology, Baylor College of Medicine

Integra FoundationNeurocritical Care Society

National Institute of Neurological Disorders and Stroke