Neurology: Case of the Month

Test Yourself — Patient 79

Susac's Syndrome

1. Cotton-wool spots seen on funduscopic examination are MOST suggestive of which of the following:
   • [ A ] Arboviral encephalitis
   • [ B ] Multiple sclerosis exacerbation
   • [ C ] Vasculitis
   • [ D ] Refractive error
2. Susac's syndrome may be distinguished from multiple sclerosis by the presence of WHICH of the following findings on magnetic resonance (MR) imaging:
   • [ A ] Gray matter involvement
   • [ B ] Prominent involvement of the corpus callosum
   • [ C ] Multifocal supratentorial lesions
   • [ D ] A and B
   • [ E ] All of the above
3. Apparent clinical responsiveness to methylprednisolone treatment may frequently be seen in all of the following conditions, EXCEPT:
   • [ A ] Lymphoma
   • [ B ] Progressive multifocal leukoencephalopathy
   • [ C ] Multiple sclerosis
   • [ D ] CNS vasculitis
4. Which of the following statements are TRUE?
   • [ A ] Randomized, controlled trials have convincingly demonstrated the efficacy of glucocorticoid treatment in patients with Susac's syndrome.
   • [ B ] Short-term memory loss is rare in patients with Susac's syndrome, especially if treatment is begun quickly.
   • [ C ] Cerebral angiography is a sensitive screening procedure for patients with suspected Susac's syndrome.
   • [ D ] Mitochondrial disorders may mimic many of the features of Susac's syndrome.
   • [ E ] All of the above are true.
5. Intravenous or oral anticoagulation are useful adjuncts in treatment of patients with Susac's syndrome.
   • [ A ] True
   • [ B ] False

 

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