Test Yourself — Patient 6

Inclusion Body Myositis

  1. The following statement is true about sporadic Inclusion Body Myositis (sIBM):
    • [ A ] occurs more often in females
    • [ B ] usually presents before the age of 50
    • [ C ] distal muscle weakness is rare
    • [ D ] none of the above are true
  2. The following muscle biopsy feature is not seen in hereditary Inclusion Body Myositis (hIBM):
    • [ A ] rimmed vacuoles
    • [ B ] atrophic denervated fibers
    • [ C ] eosinophilic inclusions
    • [ D ] mild to moderate inflammation
  3. The following EMG findings would typically be seen in a patient with sporadic Inclusion Body Myositis (sIBM):
    • [ A ] myopathic units
    • [ B ] fibrillations and positive sharp waves
    • [ C ] polyphasics of normal and longer durations and increased amplitudes
    • [ D ] all of the above
  4. All of the following statements are true regarding sporadic IBM (sIBM) EXCEPT:
    • [ A ] the muscle pathology of rimmed vacuoles and eosinophilic inclusions is specific
    • [ B ] steroids are generally ineffective in the treatment of sIBM
    • [ C ] the etiology is thought to be via an immune-mediated mechanism
    • [ D ] dysphagia is a common symptom
  5. All of the following are helpful in differentiating sporadic IBM (sIBM) from polymyositis EXCEPT:
    • [ A ] the presence of lymphocytes on muscle biopsy
    • [ B ] the response to immunosuppressant therapy
    • [ C ] distal weakness in the upper extremities
    • [ D ] the presence of beta-amyloid, phosphorylated tau, and ubiquitin on muscle biopsy

 

Email comments: