Test Yourself — Patient 35 Progressive Non-fluent Aphasia (formerly Primary Progressive Aphasia) Typical frontotemporal lobe degeneration syndromes include all of the following, EXCEPT: [ A ] Frontotemporal dementia [ B ] Lewy body dementia [ C ] Semantic dementia [ D ] Progressive nonfluent aphasia One of the familial forms of FTDP (frontotemporal degeneration with parkinsonism) has been mapped to which chromosomal locus? [ A ] 5q11-13 [ B ] 17q21-22 [ C ] 17p11.2 [ D ] 19q13.2 Which candidate gene for FTDP lies within the region specified in question (2)? [ A ] Beta-amyloid precursor protein (beta-APP) [ B ] Apolipoprotein E [ C ] Microtubule-associated protein (tau) [ D ] Alpha-synuclein [ E ] Presenilin-1 Which clinical scenario is most consistent with a diagnosis of primary progressive aphasia? [ A ] Early mutism, early amnesia, and late behavioral changes [ B ] Early loss of social skills followed by anomia and apraxia [ C ] Memory loss followed by rapid onset of aphasia [ D ] Progressive impairment of expressive language, with mutism and behavioral changes as late features Supportive features for a diagnosis of progressive aphasia include all, EXCEPT: [ A ] Primitive reflexes, bradykinesia, rigidity, and tremor [ B ] Spatial disorientation, logoclonic speech, myoclonus, and cerebellar ataxia [ C ] Mildly asymmetric EEG and functional imaging [ D ] Onset before age 65, with a positive family history [ E ] Co-occurrence of motor neuron disease Email comments:
Baylor College of Medicine