Neurology: Case of the Month

Test Yourself — Patient 2

Isaacs' Syndrome

1. The following symptom/sign is commonly seen in Isaacs' syndrome
   • [ A ] increased reflexes
   • [ B ] percussion myotonia
   • [ C ] muscle cramping
   • [ D ] proximal muscle weakness
2. Characteristic EMG findings in a patient with Isaacs' syndrome may include
   • [ A ] doublets
   • [ B ] neuromyotonic discharges
   • [ C ] myokymic discharges
   • [ D ] all of the above
3. Therapy for Isaacs' syndrome may include all of the following EXCEPT:
   • [ A ] phenytoin
   • [ B ] tegretol
   • [ C ] benzodiazepines
   • [ D ] plasma exchange
4. The following is true about Stiffman's syndrome
   • [ A ] the muscle stiffness persists in sleep
   • [ B ] is associated with anti-GAD antibodies
   • [ C ] myokymia is seen on EMG
   • [ D ] phenytoin and carbamazepine are beneficial in the treatment of stiffness
5. The underlying cause of Isaacs' syndrome is thought to be
   • [ A ] altered myelination
   • [ B ] antibodies influencing the potassium channel
   • [ C ] vasculitis
   • [ D ] impaired axoplasmic transport

 

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