« Back to protocol index

PI Name Protocol Number Protocol Title Status Approval Date
LAU, CHANTAL H-20976 VISCOSITY VARIABILITY IN BREAST MILK AND INFANT FORMULAE WITH THE USE OF THICKENERS Approved  

 

Funding Source

Baylor

Background Info
Infants who have difficulty feeding by mouth may experience episodes of coughing, choking, and/or aspiration. Under such circumstances, speech-language pathologists (SLP) will routinely conduct a videofluoroscopic swallow study (VFSS), also called modified Barium study (MBS) in order to identify by x-ray the potential causes that put infants at risk of aspiration. Causes in swallowing difficulties include (1) during the oral phase of swallow, decreased lingual control which may lead to poor bolus formation and/or delayed initiation of the swallow reflex and/or (2) during the pharyngeal phase of swallow, discoordination of the pharyngeal musculature leading to delayed bolus transport into the esophagus and/or untimely epiglotic closure leading to liquid aspiration into the lungs .

If aspiration is present when swallowing milk/formula, the latter is thickened to a consistency that the infant can handle without any further sign of aspiration. Based on such observation, SLPs customarily recommend that the milk/formula be thickened to a consistency similar to that of "nectar", "honey" etc... However, accurate reproduction of the appropriate consistency recommended by SLPs is difficult to replicate because there are different levels of "nectar" or "honey". In addition, VFSS necessitates the use of a contrasting agent, most commonly being 40% barium sulfate, in order to view the swallowing process with the same image quality regardless of the viscosity of the liquid. It is unclear the extent to which barium sulfate intrinsically increase milk/formula even when no thickener is added. It is therefore understandable that attempts at replicating the consistency recommended by SLPs by the bedside is difficult and very subjective. In addition, replicating the recommended thicknesses, at times, can create new problems. Indeed, as thickened milks do not always flow out of the bottles readily, nipple holes are enlarged in order to allow for flow without considering whether the resulting increased flow can be handled safely by the infants.

Depending upon the type of thickeners used, e.g., rice cereal flakes, some will thickened over time. For instance, with rice cereal, over time, flakes agglutinate and plug the bottle nipples making it even more difficult for the infant to suck.

Purpose and Objectives
The purpose of this study is to improve on the ability of caretakers to replicate the milk/formula consistencies recommended by SLPs following a VFSS assessment for infants suspected of aspiration. This can be carried out by measuring the actual viscosities (centipoise, cp) of the solutions used by SLPs during their assessments and determining the amount of specific thickeners needed to replicate such consistencies (w/v). Temporal viscosity changes of the thickened milk/formula need to be measured as this would provide a time window during which the feeding ought to be carried out. In addition, appropriate bottle nipple size need also be identified for the various thicknesses recommended based on the type of thickeners used to insure that appropriate flow rate are obtained.
Design
Other
Potential Risks
None
Potential Benefits
None

^Back to top^