Infants> 1500 Grams
1. Spontaneously breathing infant requires > 50% oxygen in the first day of life and has a history compatible with HMD. Such patients are candidates for CPAP by endotracheal tube and treatment with rescue surfactant.
2. Infants requiring IPPV and with a PaO2/PAO2 ratio <0.22 (FiO2>35%) qualify for diagnosis of HMD and rescue surfactant treatment.
3. Negative blood culture (if done).
Infants <1500 Grams
1. Infant is on IPPV. Prior to or following treatment with surfactant, the PaO2/PAO2 ratio is <0.22 (FiO2>35%) for more than twelve hours.
2. Infants treated with CPAP because of oxygen requirement >50% meet diagnostic criteria for HMD and also qualify for rescue surfactant treatment.
3. Negative blood culture (if done).
Baylor College of Medicine - Neonatology Section
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