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Course Curriculum Syllabus

2015-2016


  
Term 1
  
  Course: GS-GS-501: Organization of the Cell
Course Director(s): Pedersen, Steen E \ Sifers, Richard N
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Aug 032:30 PMN315Overview and the Secretory PathwayCourse organization, outline etc. General protein expression and maturation. The secretory pathway and nature of various organelles.
  2Wed Aug 052:30 PMN315Nuclear TransportOverall structure of the nucleus and nuclear pore complexes. Transport of proteins and RNAs into and out of the nucleus. Nuclear transport and the control of gene expression
  1Thu Aug 065:15 PMN315OC-TA1Review general cell structures, their function and generation. Concepts of vesicular transport and protein import and export for the organelles
  3Fri Aug 072:30 PMN315Mitochondria and PeroxisomesStructure and biogenesis of mitochondria and peroxisomes. Protein import into these organelles
  4Mon Aug 102:30 PMN315The Endoplasmic ReticulumQuality control checkpoint and mother of the endomembrane system
  5Wed Aug 122:30 PMN315The Golgi ComplexRegulated vesicular trafficking in the endomembrane system
  2Thu Aug 135:15 PMN315OC-TA2Review of additional protein trafficking schemes
  6Fri Aug 142:30 PMN315Cytoskeleton IActin, microtubules, intermediate filaments, junctional complexes and cellular architecture, cell motility.
  7Mon Aug 172:30 PMN315Cytoskeleton IIActin, microtubules, intermediate filaments, junctional complexes and cellular architecture, cell motility.
  1Wed Aug 192:30 PMN315Midterm Review
  3Thu Aug 205:15 PMN315OC-TA3Review of cytoskeleton
  1Fri Aug 211:15 PMN315OC Midterm Exam
  8Mon Aug 242:30 PMN315Vesicular Transport in ReverseThe plasma membrane-endosome-lysosome connection
  9Wed Aug 262:30 PMN315ApoptosisApoptosis versus necrosis, mechanisms of programmed cell death, regulators of apoptosis.
  10Fri Aug 282:30 PMN315G ProteinsSignalling mechanisms, ligand recognition and conformation changes by receptors, GDP release kinetics, G protein structure and function, effectors, signal processing, inactivation and desensitization, receptor kinases and arrestins, putative roles for PKC
  11Wed Sep 022:30 PMN315Growth Factors/Tyrosine Kinase SignalingLigands and signals, structure of families of membrane receptors with intrinsic tyrosine kinase activity and introduction to cascades activated by binding to phosphotyrosines, SH2 and SH3 domains, tyrosine kinases associated with membrane bound receptors
  4Thu Sep 035:15 PMN315OC-TA4Review of endocytosis, apoptosis and G-protein signaling
  12Fri Sep 042:30 PMN315Energy Transduction and BioenergeticsMembrane permeability, mechanisms of transport, bio-energetics, mitochondrial and chloroplast function, chemiosmosis
  13Wed Sep 092:30 PMN315Calcium and phospholipase signalingCalcium and its protein complexes Phosphoinositides, phospholipase C, protein kinase C, IP3 receptors, proteins regulated by Ca, calmodulin, Ca-regulated channels, annexins, overview of methods for monitoring intracellular Ca and phosphoplipase activity
  5Thu Sep 105:15 PMN315OC-TA5Review of tyrosine kinase signaling, energy transduction and calcium signaling
  14Fri Sep 112:30 PMN315Transport MechanismsActive and passive transport, synporters, antiporters, ATPases
  15Mon Sep 142:30 PMN315Ion channelsNernst potential, electrical properties of excitable membranes, action potential
  1Wed Sep 162:30 PMN315Faculty Review
  6Thu Sep 175:15 PMN315OC-TA6Review of bioenergetics, transporters and ion channels
  1Fri Sep 181:15 PMN315OC Final Exam1:00-4:00
  
  Course: GS-GS-502: Molecular Methods
Course Director(s): Weigel, Nancy L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Aug 031:15 PMN315IntroductionOverview of course contents and schedule
  2Wed Aug 051:15 PMN315DNA Manipulation, Amplification and DetectionEnzymes to modify, label amplify or quantify nucleic acids; Polymerase chain reaction(PCR) and derivatives such as hybrid PCR, quantitative PCR, real time PCR, droplet PCR
  3Fri Aug 071:15 PMN315DNA Cloning IApplications of cloning, vectors, transformation methods, plasmid purification systems, traditional cloning methods, cloning diagnosis.
  4Mon Aug 101:15 PMN315DNA Cloning IIApplications of advanced cloning and mutagenesis; Gateway, sequence and ligation independent cloning, Gibson cloning, Type II's cloning; mutagenesis
  1Tue Aug 115:15 PMN315MM-TA1Lectures 1-4
  5Wed Aug 121:15 PMN315Flow CytometryIntroduction to the technique of flow cytometry and cell sorting, detecting fluorescent cells through expressed antigens and endogeneous fluorescent molecules
  6Fri Aug 141:15 PMN315cDNA and Genomic LibrariesConstruction and handling of cDNA libraries; whole genome libraries, targeted strategies such as exome and regional capture, circulating cell-free genomic libraries
  7Mon Aug 171:15 PMN315First-Generation Sequencing and GenotypingIntroduction to Maxam-Gilbert, Sanger and automated Sanger sequencing; microarrays, high-throughput genotyping assays
  2Tue Aug 185:15 PMN315MM-TA2Lectures 5-7
  8Wed Aug 191:15 PMN315Next Generation SequencingTechnology approaches and advances of current NGS platforms focusing on both clonally-amplified and single molecule strategies, alignment for variant detection; haplotype phasing and structural variant detection.
  9Mon Aug 241:15 PMN315Genomic ProfilingFunctional assays using NGS: RNA sequencing(RNA-Seq) and data analysis, single cell analyses, other functional sequencing assays
  3Tue Aug 255:15 PMN315MM-TA3Lectures 8-10
  10Wed Aug 261:15 PMN315Antibody Production, Characterization and Research ApplicationsMonoclonal antibodies(mAbs) - mouse and rabbit hybridomas, B cell IgG cloning and recombinant single domain mAbs; polyclonal antibodies; antibodies to protein post-translational modifications and peptides, characterization and validationo of Abs.
  1Fri Aug 281:15 PMN315Midterm Review
  1Tue Sep 011:15 PMN315MM Midterm Exam
  11Fri Sep 041:15 PMN315RNA Interference and genetic screensRNA interference(RNAi) mechanisms, RNAi tools, genetic screening methods, technical considerations in using RNAi
  12Tue Sep 082:30 PMN315Proteomics Mass Spectrometry - Basic PrinciplesMass spectometer instruments and analytical methods; principles of identification for peptides and post-translational modifications(PTMs); data processing
  13Wed Sep 091:15 PMN315Proteomics Mass Spectrometry - Applications in BiologyMS-based quantification, global proteome profiling, PTM profiling, protein-protein interaction networks from IP/MS
  4Wed Sep 095:15 PMN315MM-TA4Lectures 11-13
  14Fri Sep 111:15 PMN315Detection of Protein-Protein InteractionsPrinciples of: Western immunoblotting, Westerns coupled to co-immunoprecipitation; in vitro(GST) pull-down assays; yeast two-hybrid system; bimolecular fluorescence complementation(BiFC) and phage display
  15Mon Sep 141:15 PMN315Visualizing ProteinsImmunohistochemical detection methods; lacZ reporters; green fluorescence protein(GFP) reporters; luciferase reporters; fluorescence resonance energy transfer(FRET); bimolecular fluorescence complementation(BiFC); fluorescence recovery after photobleac
  16Wed Sep 161:15 PMN315High Throughput MethodsChromatin immunoprecipitation(ChIP) on ChIP(ChIP-Chip); ChIP and high throughput DNA sequencing(ChIP-Seq); protein microarrays(i.e.reverse and forward phase protein microarrays); tissue microarrays.
  17Mon Sep 211:15 PMN315Protein ExpressionExpression systems(E.coli, yeast, insect and mammalian cells), fusion tags(6x His, GST, MBP, intein); co-expression for protein complexes and in vitro translation
  5Tue Sep 225:15 PMN315MM-TA5Lectures 14-16
  18Wed Sep 231:15 PMN315Protein PurificationCell disruption methods; centrifugation, ammonium sulfate precipitatn, liquid chromatography(affinity, ion exchange, hydrophobic, size exclusion); SDS-PAGE; evaluting protein concentration(Bradford and extinction coefficients) and biological assays.
  19Fri Sep 251:15 PMN315Purification of Epitope-tagged Proteins and Refolding StrategiesPrufication of epitope tagged proteins; inclusion bodies; protein refolding strategies; disulfide formation and artificial chaperones.
  6Fri Sep 255:15 PMN315MM-TA6Lectures 17-19
  1Mon Sep 281:15 PMN315Faculty Review
  1Wed Sep 301:15 PMN315MM Final Exam1:00-4:00
  
  Course: GS-GS-503: Genetics A
Course Director(s): Herman, Christophe \ Dierick, Herman A.
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Aug 041:15 PMN315Mendelian GeneticsGene nomenclature: gene/allele/genotype/phenotype.Dominant v.recessive mutations.Mendel's laws. Penetrance v. expressivity.
  2Thu Aug 061:15 PMN315Cellular Mechanisms of Mendelian Genetics and LinkageMeiosis v.mitosis.Linkage.Two-point and three-point mapping. Complementation.
  3Tue Aug 111:15 PMN315Statistical Methods in Genetics.Basics of pedigrees.Binomial statistics: identifying probabilities of alternative choices.Bayesian statistics: altering a priori probability.X square tests: testing data against a model.
  4Thu Aug 131:15 PMN315Population GeneticsMultifactorial traits: continuous, dichotomous and meristic traits.Polygeneticity and heritability. Allele frequencies, genotype frequencies and Hardy Weinberg.Inbreeding and inbreeding coefficients. Selection and balanced polymorphisms.
  5Tue Aug 181:15 PMN315Genetic ScreensMutant building: discovering genes involved in a biological process through screens.Mutagens and screen saturation.Yeast genetics and tetrad analysis.
  1Wed Aug 195:15 PMN315GA-TA1General Genetic Principles
  6Thu Aug 201:15 PMN315Selecting and Identifying MutantsIdentifying mutated genes.Selection and screening strategies, reporter genes and secondary screens.
  7Tue Aug 251:15 PMN315Genetic SuppressionGenetics as a study of how proteins interact, fold and function.Mechanisms of genetic suppression.Genetic enhancement and synthetic lethality.
  8Thu Aug 271:15 PMN315Epistasis and Pathway AnalysisDetermining the order of action of proteins in a pathway by epistatis analysis.Ordering genes in metabolic and regulatory pathways.
  1Thu Aug 272:30 PMN315Faculty Review
  2Fri Aug 285:15 PMN315GA-TA2Phenotype, pathway analysis and genetics screens
  1Mon Aug 311:15 PMN315GA Mid-term Exam1:00-4:00
  9Thu Sep 031:15 PMN315Viral/Phage Genetics.Virus cycle, complementation group.
  10Tue Sep 081:15 PMN315Bacterial Genetics IGenetic transmission: haploid and circular genomes, P1-transduction, F-factors, HFRs, conjugation.
  11Thu Sep 101:15 PMN315Bacterial Genetics IIRecombination.
  12Tue Sep 151:15 PMN315Bacterial Genetics IIISOS response, transposition
  13Thu Sep 171:15 PMN315Genetic Engineering IArtificial chromosomes, recombineering in bacteria, homing endonucleases(I-SceI), seamless versus remnant engineering
  3Fri Sep 185:15 PMN315GA-TA3Bacterial Genetics
  14Tue Sep 221:15 PMN315Genetic Engineering IIIntegrases, Zn finger technology, TALE technology, Crispr/Cas technology
  1Thu Sep 241:15 PMN315Faculty Review
  4Thu Sep 245:15 PMN315GA-TA4Genetic Engineering
  1Fri Oct 021:15 PMN315GA Final Exam1:00-4:00
  
  Course: GS-GS-513: Science as a Profession
Course Director(s): Smith, Carolyn L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Aug 042:30 PMN315Organization of the literatureOrganization and purpose of a paper, how to read the current literature, what is contained in the various sections of a paper, computer searching vs browsing, parts of a scientific paper and what you can learn from each
  2Tue Aug 112:30 PMN315The Scientific Method - thinking and talking like a scientistThe scientific method (hypothesis vs results-driven science), elements of experimental design (developing models/hypotheses), designing experimental tests of your hypotheses, fishing expeditions, controls , replication of experiments and data selection -
  3Tue Aug 182:30 PMN315The funding structure of science and public policyGovernment organizations, private funding sources, applying for fellowships, structure of a grant, grant review system, science advocacy
  4Tue Aug 252:30 PMN315Setting goals for your scientific development and coping with challengesCareer paths for the professional scientist, career decisions (how and when to make them), what to do in your first year to ensure your success, developing curiosity, coursework(what to expect in gradschool), lifelong learning, the scientific literature,
  
  Course: GS-GS-514: Ethics - Year 1
Course Director(s): Smith, Carolyn L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Thu Sep 032:30 PMN315(1L2) Responsible authorship and publicationgiving credit when credit is due, when to cite or not, how to use direct quotes, paraphrasing, plagiarism, copyright and copyright permissionSmith, Carolyn L
  2Thu Sep 102:30 PMN315(1M) The Mentor/Student relationshipSelecting a lab and developing a group of mentors, what to look for in rotations, keeping on track toward your degree
  3Thu Sep 172:30 PMN315(1C) Case Studies Data Management/Plagiarismrecord keeping, ownership of research materials, responsible citation, and plagiarism
  4Thu Sep 242:30 PMN315(1L1) Data aquisition and record keeping responsibilitiesresponsibilities for record keeping, challenges in keeping accurate and understandable notebooks, ownership of research materials, reagent/data sharing
  
  
Term 2
  
  Course: GS-GS-504: Genetics B
Course Director(s): Zhou, Zheng
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Oct 131:15 PMN315IntroductionForward and reverse genetics.Strengths of model systems.Nomenclature.The concept of maternal effect.
  2Thu Oct 151:15 PMN315Yeast IBasic molecular manipulations in reverse genetics: cloning by complementation, plasmid gap repair, gene disruption/replacement, plasmid shuffle
  3Tue Oct 201:15 PMN315Yeast IIGenome analysis and functional genomics.The impact of the yeast genome project.Systematic manipulation of entire gene sets to monitor mRNA expression and protein localization in vivo.
  1Wed Oct 215:15 PMN315GB-TA1Held in N315
  4Thu Oct 221:15 PMN315C.elegans IAdvantages and special considerations of hermaphrodite genetics.How to construct strains, strategies of genetic screens, cloning genes, balancers.
  5Thu Oct 222:30 PMN315C.elegans IIC.elegans transformation.Impact of the C.elegans genome project.Reverse genetics using RNA interference and gene deletions.Studies of gene interaction.
  6Tue Oct 271:15 PMN315Drosophila IIntroduction.Nomenclature and markers; chromosome cytology(polytene chromosomes) and chromosome rearrangements; using balancer chromosomes to follow segregation and to isolate mutations; P-elements and transformation; site-specific integration using th
  2Wed Oct 285:15 PMN315GB-TA2Held in N315
  7Tue Nov 031:15 PMN315Drosophila IIGenetic screens.Mutagens: ems, x-rays and P-elements; classic genetic screens to identify mutations in Drosophila: F1, F2, F3 screens; modifier(suppressor and enhancer) screens; isolating mutations, mapping lethal mutations; deficiency mapping; high-th
  8Thu Nov 051:15 PMN315Drosophila IIIGene function.Mosaic analysis; autonomy versus non-autonomy; mitotic recombination using the FLP/FRT system, methods of marking clones; ectopic expression using heat shock, GAL4-UAS, and flp-out; MARCM analysis.
  3Fri Nov 065:15 PMN315GB-TA3Held in 201A
  1Tue Nov 102:30 PMN315Faculty Review
  1Thu Nov 121:15 PMN315GB Midterm Exam1:00-4:00
  9Tue Nov 171:15 PMN315Mouse Genetics IInbred mice. Microsatellite markers. Mapping genes in mice using crosses.
  10Thu Nov 191:15 PMN315Mouse Genetics IIInsertion of DNA and retrotransposons.Knock-outs and ins.Conditional knock-outs.
  4Fri Nov 205:15 PMN315GB-TA4Held in 201A
  11Mon Nov 231:15 PMN315Human Genetics IDisease loci and pedigrees.
  12Thu Dec 031:15 PMN315Human Genetics IIMapping with DNA markers.Sources of polymorphisms. Simple vs. complex traits. Genome scans for quantitative trait loci.
  13Fri Dec 041:15 PMN315Human Genetics IIIEffect of imprinting on pedigrees.Models for specific mechanisms of imprinting.Model for evolutionary significance.
  5Fri Dec 045:15 PMN315GB-TA5Held in 201A
  1Wed Dec 091:15 PMN315Faculty Review
  1Fri Dec 111:15 PMN315GB Final Exam1:00-4:00
  
  Course: GS-GS-505: Cell Division
Course Director(s): Ira, Grzegorz \ Chang, Eric C
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Wed Oct 141:15 PMN315Course Introduction/Cell Cycle OverviewDiscovery of cell cycle regulation--Cell cycle stages, mitosis and meiosis, discovery of CDK/cyclin/MPF
  2Fri Oct 161:15 PMN315S phaseInitiation and control of DNA replication at origins of replications
  3Mon Oct 191:15 PMN315Principles of cell cycle regulation ICDKs, cyclins, CKIs, and proteolysis
  1Tue Oct 205:15 PMN315CD-TA1Review of cell cycle basics, S phase
  4Wed Oct 211:15 PMN315Principles of cell cycle regulation IICell cycle transitions, G1/S and G2M
  5Fri Oct 231:15 PMN315Cell Cycle CheckpointsIntroduction to cell cycle checkpoints, the DNA damage checkpoint
  6Mon Oct 261:15 PMN315DNA DamageDNA damage and repair
  1Mon Oct 262:30 PMN315Faculty Review MidtermLectures 1-7
  2Tue Oct 275:15 PMN315CD-TA2Review of DNA recombination and repair
  1Wed Oct 281:15 PMN315CD Midterm ExamLectures 1-7
  7Fri Oct 301:15 PMN315DNA RepairRepair of double strand breaks by homologous and non-homologous recombination
  8Mon Nov 021:15 PMN315ChromosomesChromatin duplication and M phase chromosomes organization
  9Fri Nov 061:15 PMN315TelomeresStructure and synthesis.Telomere dysfunction-induced DNA damage checkpoint response.Crisis and survival in the absence of telomerase.
  10Mon Nov 091:15 PMN315M phase spindleMechanisms of spindle formation and function, kinetochore/spindle attachment
  3Tue Nov 105:15 PMN315CD-TA3Review of chromosome/chromatin/telomeres
  11Wed Nov 111:15 PMN315CytokinesisCytokinesis mechanisms
  12Fri Nov 131:15 PMN315Growth regulationThe cell cycle in growth regulation, development and cancer
  1Tue Nov 172:30 PMN315Faculty ReviewLecture 8-12
  4Tue Nov 175:15 PMN315CD-TA4Review of cytokinesis, spindle & kinetochore assembly and growth regulation
  1Wed Nov 181:15 PMN315CD Final ExamLectures 8-12. (1:00-4:00 PM)
  
  Course: GS-GS-506: Development
Course Director(s): Groves, Andrew Kelton
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Wed Oct 142:30 PMN315DE Seminar
  2Fri Oct 162:30 PMN315Core Concepts in Developmental Biology
  3Mon Oct 192:30 PMN315Setting up the vertebrate body plan IAxis determination and gastrulation
  4Wed Oct 212:30 PMN315Setting up the vertebrate body plan IIMammalian development and embryonic stem cells
  1Thu Oct 225:15 PMN315TA-DE1
  5Fri Oct 232:30 PMN315Patterning the embryo from head to tail
  2Thu Oct 295:15 PMN315TA-DE2
  1Mon Nov 022:30 PMN315Mid-Term Faculty Review
  1Wed Nov 041:15 PMN315DE Midterm Exam1:00-4:00
  6Fri Nov 062:30 PMN315ES cells, pluripotency and reprogramming / iPS
  7Mon Nov 092:30 PMN315Stem cells in the adult
  8Wed Nov 112:30 PMN315Introduction to Drosophila embryogenesisOverview of Drosophila oogenesis and embryogenesis
  3Thu Nov 125:15 PMN315TA-DE3
  9Fri Nov 132:30 PMN315Embryonic patterning in Drosophila - IMaternal-effect genes and the establishment of the anteroposterior axes
  10Mon Nov 162:30 PMN315Embryonic patterning in Drosophila IIMaternal-effect genes and the establishment of the dorsoventral axes
  11Thu Nov 192:30 PMN315Limb DevelopmentA model system to illustrate developmental concepts
  1Fri Nov 202:30 PMN315Faculty Review
  1Tue Nov 241:15 PMN315DE Final Exam1:00-4:00
  
  Course: GS-GS-508: Cancer
Course Director(s): Pangas, Stephanie A
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Nov 161:15 PMN315Introduction to Cancer CourseMouse models of cancer using lung cancer as an example
  2Fri Nov 201:15 PMN315Oncogenes
  3Mon Nov 232:30 PMN315Cancer as a Multi-Step Process
  4Mon Nov 302:30 PMN315Tumor Cell - Stromal Interactions
  5Wed Dec 022:30 PMN315Metastasis
  6Fri Dec 042:30 PMN315Cancer Stem Cells
  1Mon Dec 071:15 PMN315Faculty Review
  1Tue Dec 081:15 PMN315CA Final Exam1:00-4:00
  
  Course: GS-GS-515: Ethics - Year 2
Course Director(s): Smith, Carolyn L \ Smith, Carolyn L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Oct 1910:00 AMN315(2L1) Research misconduct - (NIH b3) Safe Practices in the LaboratoryDefinitions - Falsification, fabrication, plagiarism – whistleblowers, allegations, investigations, penalties. College policy and mechanisms for handling misconduct allegations, federal policies and procedures. (NIH b3) Safe Practices in the Laboratory
  2Mon Oct 2610:00 AMN315(2M) MentorshipMeeting with 2nd year students and their mentors, matching expectations between mentor student, developing communication channels, picking an appropriate thesis topic, the thesis committee as a resource
  3Mon Nov 0210:00 AMN315(2L2) Ethics of Experiments with Animalswhen can animals be used ethically in research, avoiding unnecessary pain/suffering and euthanasia, appropriate selection of numbers/types of animals in research, animal use approval
  
  Course: GS-GS-523: Method and Logic in Molecular Biology
Course Director(s): Mardon, Graeme
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Thu Oct 1511:00 AMN315Method and Logic MeetingAttendance at this class (to be held in N315) is mandatory for all students who intend to take this course.This organizational meeting begins at 10:15 and runs until 11:45 AM.
  2Tue Oct 2011:00 AMN315Method and Logic MeetingClasses will be held in N302, N304, N310, N317 and M303 from this class onwards. Classes begin at 10 AM and end at noon.
  3Thu Oct 2211:00 AMN315Method and Logic Meeting
  4Tue Oct 2711:00 AMN315Method and Logic Meeting
  5Fri Oct 3011:00 AMN315Method and Logic Meeting
  6Tue Nov 0311:00 AMN315Method and Logic Meeting
  7Thu Nov 0511:00 AMN315Method and Logic Meeting
  8Tue Nov 1011:00 AMN315Method and Logic Meeting
  9Thu Nov 1211:00 AMN315Method and Logic Meeting
  10Tue Nov 1711:00 AMN315Method and Logic Meeting
  11Thu Nov 1911:00 AMN315Method and Logic Meeting
  12Tue Dec 0111:00 AMN315Method and Logic Meeting
  13Thu Dec 0311:00 AMN315Method and Logic Meeting
  
  Course: GS-GS-527: ABC-Applications to Biology of Computation
Course Director(s): Lichtarge, Olivier \ Milosavljevic, Aleksandar
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Oct 139:00 AMN315Big Data GeneticsThis lecture will introduce genome interpretation and will cover(1) opportunities for genetics-driven biology that will be opened by the sequencing of millions of genomes during this decade; (2) efforts by the Clinical Genome Resource project to develop
  1Wed Oct 145:15 PMN315TA Session 1Hardware and Contemporary Computing Infrastructure.This TA session will be held in 301A.
  2Thu Oct 159:00 AMN315Network BiologyInference and knowledge representation.This lecture will focus on (1) inference of pathways, networks, and network modules; (2) Interpretation of Big Data experiments using networks, pathways, and modules as background knowledge; (3) Computational repres
  2Fri Oct 165:15 PMN315TA Session 2A Beginner’s guide to UNIX / Linux and qsub commands.This TA session will be held in 301A.
  3Tue Oct 209:00 AMN315A Primer in Network Biology IElements in transcription networks, network motif and graph theory.
  4Thu Oct 229:00 AMN315A Primer in Network Biology IINetwork inference from genomics data. This class will be held in 201A
  5Tue Oct 279:00 AMN315Computational Analysis of Networks and Pathways IIntroduction to computational methods to analyze biological information from networks.
  6Fri Oct 309:00 AMN315Computational Analysis of Networks and Pathways IIComputational methods to decode and to analyze biological information from networks - advanced topics.
  7Tue Nov 039:00 AMN315Big Data GeneticsThis lecture will introduce genome interpretation and will cover(1) opportunities for genetics-driven biology that will be opened by the sequencing of millions of genomes during this decade; (2) efforts by the Clinical Genome Resource project to develop
  8Thu Nov 059:00 AMN315Cancer GenomicsApplication of NGS variation analysis onto tumor samples.How do tumor genomes differentiate from normal genomes? What have we learned from large- scale cancer genome sequencing such as TCGA, etc.?
  9Tue Nov 109:00 AMN315Recent Developments in Gene MappingFocused on gene mapping approach and current approach and challenges in functional annotation, interpretation and prioritization.It will review the basic disease models (common vs rare) and gene mapping frameworks(GWAS, Exome, CVAS vs RVAS). It will als
  10Thu Nov 129:00 AMN315Cancer Genomic MedicinePractical challenges on implementing NGS-based tests in a cancer clinics.Why is it important(some case examples)? Progresses made so far.What are the missing pieces? Opportunities for biomedical computational science.
  11Tue Nov 179:00 AMN315NGS Variation AnalysisFocused on the SNP calling algorithms in NGS datasets, for both personal genome(when N = 1) and population genomic studies(when N = many). It will serve as an introduction lecture and review the most popular SNP callers applied the NGS data analysis, inclu
  12Thu Nov 199:00 AMN315From Sequence to StructureA brief overview of the sequence-based tools and algorithms used to interpret protein structure and function.This lecture will also highlight current approaches in homology and template-free modeling.
  13Mon Nov 239:00 AMN315Macromolecular StructureThis lecture focuses on methods for interpreting and modeling macromolecular structure and function, as well as validation methods commonly used with these techniques.A particular emphasis will be on integrative or hybrid methods that combine multiple ty
  14Tue Nov 249:00 AMN315Sequence-Structure-Function IThis lecture will be an overview of common tools utilized in evolutionary analysis: BLAST, alignments, substitution matrices, and phylogenetic trees.
  15Tue Dec 019:00 AMN315Sequence-Structure-Function IIThis lecture will focus on tools that take advantage of evolutionary information in order identify function and functional sites.
  16Thu Dec 039:00 AMN315Evolutionary AnalysisA formal approach to the genotype-phenotype relationship with molecular, clinical and population genetics applications.This class will be held in N315
  1Thu Dec 109:00 AMN315ABC - Final ExamFinal Exam will be held in N315.
  
  
Term 3
  
  Course: GS-GS-509: Gene Regulation
Course Director(s): Cooper, Thomas
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Jan 041:15 PMN315Introduction to Gene RegulationSites of Gene Regulation: transcription initiation, termination, alternative RNA splicing, 3' end processing, nuclear export, cytoplasmic mRNA stability, translational regulation, protein degradation. Analysis of gene expression.Cooper, Thomas
  2Wed Jan 061:15 PMN315RNA Polymerasethe bacterial enzyme summarizing the kinetics and thermodynamics of the protein and its interactions with DNA, subunit function of the bacterial enzyme compared with the subunit structure of the eukaryotic enzyme.Regulatory functions of the polymerase.Herman, Christophe
  3Fri Jan 081:15 PMN315Control of transcription in bacteriadegradation and sequestration of initiation factors, riboswitches, noise in transcription and logic of transcriptional circuits.Herman, Christophe
  4Mon Jan 111:15 PMN315Eukaryotic RNA polymerase and transcriptional initiationStructures and activities of the 3 eukaryotic RNA polymerases.Pathways for transcription initiation by RNA pol II holoenzyme plus general transcription factors.Foulds, Charles E
  5Wed Jan 131:15 PMN315Modes of DNA binding and basic transcription factorsStructures of DNA binding domains and the molecular basis for DNA sequence recognition.How do transcription factors find their sites? Genome wide networks of transcriptional regulation.Foulds, Charles E
  1Wed Jan 135:15 PMN315GRTA1Overview of regulation of transcription and translation including review of overall process of transcription and translation, introduce reporter genes(rationale)
  6Fri Jan 151:15 PMN315Coactivators and corepressorsIdentification of transcriptional coregulators and evolution of understanding of transcriptional activation.Enymatic activities of coactivators and corepressors.Post-transcriptional modulation of coregulator function.Why are there so many coregulatoFoulds, Charles E
  7Wed Jan 201:15 PMN315Chromatin 1 - LocalHistones, nucleosomes, covalent modification of histones, DNA accessibility, insulators, locus control regions, polytene/lapbrush chromosomes.Lonard, David
  8Fri Jan 221:15 PMN315Chromatin 2 - GlobalChromatin subdomains, gene silencing, position effect variegation, epigenetic inheritance, X-inactivation, gene imprinting.Lonard, David
  9Mon Jan 251:15 PMN315Chromatin - Relationship between DNA sequence genes, transcription and ChromatinEmerging pictures of genes and chromosomes.Enabling technologies for global chromatin and transcriptome analysis, evolving understanding of gene structure, promoters, enhancers, relationship between primary DNA sequence, chromatin and transcription.Lonard, David
  10Wed Jan 271:15 PMN315Regulation of RNA Polymerase II ElongationTranscriptional elongation.Negative factors that limit elongation (NELF, DSIF); Positive factor that activates elongation(P-TEFb); HIV system(Tat, TAR RNA, P-TEFb); Drosophila heat shock genes and elongation; Current questions in this areaRice, Andrew Patrick
  2Wed Jan 275:15 PMN315GR TA2Review of assembly of transcription complex including order and identity of factor loading Identify major transcriptional activator families and mechanisms
  11Mon Feb 011:15 PMN315Nuclear export of RNANuclear pores – structure and dynamics; Retroviral systems: Retroviral life cycle, HIV system(Rev, RRE RNA, CRM1, RAN/GTP), Mason-Pfizer Monkey Virus(MMPV; CTE, TAP); Experimental methods to study RNA export; Export pathways of different classes of cellRice, Andrew Patrick
  12Tue Feb 021:15 PMN315Splicing of Pre-mRNA(I)Overview of RNA chemistry(basis for lability and reactivity), overview of RNA structure, comparisons of intron/exon architecture, Autocatalytic RNA: The spliceosome; U12-dependent introns, domain structure of RNA binding proteins.Cooper, Thomas
  1Wed Feb 031:15 PMN315Midterm Faculty Review
  1Thu Feb 041:15 PMN315GR Midterm Exam
  13Mon Feb 081:15 PMN315Splicing of Pre-mRNA(II)How the spliceosome finds vertebrate exons, intron definition vs exon definition, splicing enhancers and silencers, SR proteins, Exon junction complex(EJC), Trans-splicing.Cooper, Thomas
  14Wed Feb 101:15 PMN3153’ end formation / Polyadenylation3' end formation of pol II genes, transcription termination; cotranscriptional 3’ end formation; relationship between 3' end formation and splicing, histone 3' end formation.Cooper, Thomas
  15Fri Feb 121:15 PMN315Alternative splicingDrosophila paradigms, yeast and vertebrate systems; splicing microarrays; effects on coding potential; regulatory factors and mechanisms of regulation; signaling pathways; splicing and human disease(direct cause and as genetic modifier)Cooper, Thomas
  16Tue Feb 161:15 PMN315Translational Regulation IReview of protein synthesis and initiation steps, Cap - dependent and cap independent translation. 5'-3' interactions and recycling.Global regulation mechanisms; eIF2 kinase mechanisms, eIF4E inhibitors, viral mechanisms, mTOR, TOP mRNAs.Lloyd, Richard E.
  17Wed Feb 171:15 PMN315Translational Regulation II MechanismsmRNA-specific regulation; scanning blockers, (uORFs, IRE, autoregulatory systems), cellular IRESs, shunt mechanisms, 3' UTR-based regulation (CPEB in oocytes and neurons) - stress mechanisms (stress granules and P bodies), Frameshifting.Lloyd, Richard E.
  3Wed Feb 175:15 PMN315GR TA3Splicing and poyadenylation general overview; define mechanisms for alternative splice-site selection, intron vs exon selection
  18Fri Feb 191:15 PMN315RNA(and DNA) EditingRNA editing, Insertional/deletion editing(Mitochondrial mRNA editing, contrast with trans-esterifiction, editsome complex, spliceosome), tRNA editing and codon recognition, ADAR activity and function, interplay with the microRNA pathway, AMPA receptor, cNeilson, Joel
  19Mon Feb 221:15 PMN315Noncoding RNA FunctionBiogenesis and function of microRNAs.MicroRNA target prediction.RNAi.Modes of effecting RNAi in eukaryotic systems and forward genetic screens with shRNA libraries.LincRNAs and chromatin.Neilson, Joel
  20Wed Feb 241:15 PMN315Posttranscriptional mRNA RegulationThe impact of turnover on steady state RNA levels.e.g.histone gene expression during the cell cycle.Modes and mechanisms of RNA decay.Poly A shortening and 5' -> 3' degradation, P-bodies and mRNA decay. Non-polyA shortening mechanisms.Translation CoNeilson, Joel
  21Fri Feb 261:15 PMN315Regulation of Protein TurnoverUbiquitin-proteosome mediated degradation.Importance of regulation, protein motifs, PEST sequences, etc.Lloyd, Richard E.
  4Fri Feb 265:15 PMN315GR-TA4RNA self-splicing overview, concept of regulating synthesis and degradation of mRNA, review of ribosome assembly and initiation and termination of translation
  1Thu Mar 031:15 PMN315Faculty Review
  1Fri Mar 041:15 PMN315GR Final Exam1:00-4:00
  
  Course: GS-GS-511: Neuroscience
Course Director(s): Jankowsky, Joanna Louisa
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Thu Jan 072:30 PMN315Cellular and Structural NeuroanatomyMajor subdivions of the mammalian brain, their general organization and the specialized cells required for function.Al-Ramahi, Ismael
  2Tue Jan 122:30 PMN315Neuronal BiophysicsStructure and function of the major membrane proteins responsible for establishing ionic gradients in neurons and how they are used to transmit electrical information.Al-Ramahi, Ismael
  1Tue Jan 125:15 PMN315
  3Thu Jan 142:30 PMN315Synaptic PhysiologySpecialized structures and proteins that allow electrical signals to be converted to chemical messengers and then back again to facilitate cell-cell communicationAl-Ramahi, Ismael
  4Tue Jan 192:30 PMN315Learning and MemoryMolecular and cellular requirements for storing new information and reacalling it later.Al-Ramahi, Ismael
  2Tue Jan 195:15 PMN315
  5Thu Jan 212:30 PMN315Neurobiology of DiseaseWhat happens when things go wrong in the brain.Al-Ramahi, Ismael
  1Tue Jan 262:30 PMN315Faculty Review
  1Thu Jan 281:15 PMN315NE Final Exam1:00-4:00
  
  Course: GS-GS-512: Immunology
Course Director(s): Levitt, Jonathan Michael
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Feb 022:30 PMN315Principles of immunityOverview of the immune system: innate vs.acquired immunity, cells of the immune system, clonal selection principle, strategies for “self-nonself/danger” discriminationLevitt, Jonathan Michael
  2Tue Feb 092:30 PMN315Innate ImmunityThe gateway to defense against the world around us: pattern recognition receptors, PAMPs/DAMPs, phagocytes and chemical mediators of immunityLevitt, Jonathan Michael
  3Thu Feb 112:30 PMN315Antibody structure, antigen receptor diversity and B-cell developmentAntigens for B cells, Antibody receptor structure and genetics, Generation of diversity, Gene rearrangements and class switchingDecker, William K
  1Fri Feb 125:15 PMN315IM TA Review 1Overview of response to pathogen: Anatomy and function of organs of lymphatic system: general overview of B and T cell development and function
  4Tue Feb 162:30 PMN315B-cell activation, MHC and antigen presentationB cell development and selection.Self-nonself recognition, Tolerance, T cell antigen recognition, MHC structure and function.MHC antigen presentation and processing.Decker, William K
  5Thu Feb 182:30 PMN315Role and development of T lymphocytesTypes of T cells, T cell selection and central tolerance, education at thymic university, T cell activation and peripheral tolerance, signaling in T cells, anergy in T cells, apoptosisLevitt, Jonathan Michael
  2Fri Feb 195:15 PMN315IM TA Review 2MHC I and MHC II - functions, derivation; B cells - antibody structure - subtypes, receptors and surface molecules, VDJ recombination; T cells - receptor and surface molecules, maturation, subtypes/function; T and B cell interactions
  6Tue Feb 232:30 PMN315T cell development and signaling: consequences for transplantation and tumorsT cell effector functions, transplantation, autoimmunity, vaccines, tumor immunologyLevitt, Jonathan Michael
  1Thu Feb 252:30 PMN315Faculty Review
  1Mon Feb 291:15 PMN315IM Final Exam1:00-4:00
  
  Course: GS-GS-516: Ethics - Year 3
Course Director(s): Smith, Carolyn L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Thu Jan 079:00 AMN315(3L1) Authorship/Peer Review - NIH a) Other Conflicts of InterestOrganizing your paper, preparing manuscripts, who should be an author?, responsibilities of an author, manuscript review systems, responsibilities of a reviewer, dealing with criticism - (NIH a) Other Conflicts of Interest - conflicts of interest in the pSmith, Carolyn L
  2Thu Jan 149:00 AMN315(3L2) Collaborative research including collaborations with industryThe values/responsibilities of collaboration, establishing collaborative relationships, grants, contracts, intellectual property considerations, impact of industry collaborations on publication, thesis submissionZechiedrich, E. Lynn
  3Thu Jan 219:00 AMN315(3M) MentorshipMeeting with 3rd year students and their mentors, matching expectations between mentor student, developing communication channels, assessing your progress, risky experiments and backup projects, the thesis committee as a resourceSmith, Carolyn L
  4Thu Jan 289:00 AMN315(3C) Case Studies Peer Review/Collaborationpeer review of grants and papers, conflicts of interest, collaboration (small group discussion format with faculty facilitator)
  
  Course: GS-GS-517: Ethics - Year 4
Course Director(s): Smith, Carolyn L
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Thu Feb 049:00 AMN315(4L1) Research with Human Subjectsdefinition of research with human subjects, experiments with human material, confidentiality of medical data, experiments involving humans, informed consentBerg, Stacey L
  2Thu Feb 119:00 AMN315(4L2 The scientist as a responsible member of society.Contemporary ethical issues in biomedical research and the environmental and societal impacts of scientific researchMcguire, Amy Lynn
  3Thu Feb 189:00 AMN315(4C)Case Studies Human Research/Science and Societyresearch with human subjects, societal impact of research (genetics/genomics, stem cells, neuroethics) (small group discussion format with faculty facilitatorJohnson, Deborah L
  4Thu Feb 259:00 AMN315(4M) MentorshipMeeting with 4nd year students and their mentors, matching expectations between mentor student, maintaining communication channels, timeline for graduation, backup projects, the thesis committee as a resource, career decisions, the next step. This ClassJohnson, Deborah L
  
  Course: GS-GS-518: Macromolecules: Structure and Interactions
Course Director(s): Pedersen, Steen E \ Prasad, B V Venkatar
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Jan 042:30 PMN315IntroductionRelationship of known structural principles, structural determination, principles of interaction, thermodynamics, dynamics, and signal transduction based on binding and dynamics.Pedersen, Steen E
  2Wed Jan 062:30 PMN315Protein Structure and FoldingProtein structure elements: from building blocks to quaternary structure; protein topology; "Form follows function; protein taxonomy. Protein folding (Anfinsen theorem); energy landscapes; molecular chaperones; and protein misfolding diseases. Zhou, Ming
  1Thu Jan 075:15 PMN315MSI-TA Review 1
  3Fri Jan 082:30 PMN315Lipid/Membrane StructureLipid classification; micelles and bilayers; membrane structures; membrane proteins; mitochondria.Zhou, Ming
  4Mon Jan 112:30 PMN315DNA StructureA-, B- and Z- DNA structure; building blocks; DNA topology; from DNA to RNAZhou, Ming
  5Wed Jan 132:30 PMN315X-ray - 1Scattering, (diffraction)-based technique, diffraction theory. Reading and interpreting X-ray structure papers.Zhou, Ming
  2Thu Jan 145:15 PMN315MSI-TA Review 2
  6Fri Jan 152:30 PMN315Cryo EMCryo-electron tomography.Schmid, Michael F
  7Wed Jan 202:30 PMN315NMRBasic theory and instrumentation, NOESY, COSY methods, distance geometry, multi-dimensional NMR, sample requirements.Schmid, Michael F
  3Thu Jan 215:15 PMN315MSI-TA Review 3
  8Fri Jan 222:30 PMN315Fluorescence/optical spectroscopyPrinciples of photon absorption and emission, fluorescence energy transfer, anisotropy, lifetime instrumentation, optics. CD/IRSchmid, Michael F
  9Mon Jan 252:30 PMN315Protein – post-translational modificationsCommon reversible and irreversible post-translational modifications: regulation and roles in protein functionWeigel, Nancy L
  1Wed Jan 272:30 PMN315Midterm Faculty Review
  4Thu Jan 285:15 PMN315MSI-TA Review 4
  1Fri Jan 291:15 PMN315MS Midterm Exam1:00-4:00
  10Mon Feb 012:30 PMN315Ligand Binding & Forces in Solution/ThermodynamicsGeneral Principles of ligand binding formalism, mass action, and basic energetics.Basic forces in solution.What holds structures together? Thermodynamics of binding and how this relates to basic forces..Pedersen, Steen E
  11Wed Feb 032:30 PMN315Allostery 1Ligand binding and how it alters protein structure and dynamics; allostery and how it mediates and regulates protein function.Pedersen, Steen E
  5Thu Feb 045:15 PMN315MSI-TA Review 5
  12Fri Feb 052:30 PMN315Allostery and CooperativityHow protein structural changes mediate cooperative effects in enzymes and binding proteinsPedersen, Steen E
  13Mon Feb 082:30 PMN315Binding KineticsBasic kinetics of unimolecular and bimolecular reactions. Introduction to enzyme kinetics.Pedersen, Steen E
  14Wed Feb 102:30 PMN315Enzyme Kinetics/CatalysisMichaelis-Menten kinetics, Inhibition, kcat and kcat/Km, allosteric enzymes. Computational kinetics.Pedersen, Steen E
  6Thu Feb 115:15 PMN315MSI-TA Review 6
  15Fri Feb 122:30 PMN315Mechanisms of CatalysisAcid base catalysis, covalent catalysis, stabilization of transition states, transition state analogs, coenzymes, suicide inhibitorsPedersen, Steen E
  16Wed Feb 172:30 PMN315Single Molecule MethodsMacromolecular motors, single molecule kinetics, examplesPedersen, Steen E
  7Thu Feb 185:15 PMN315MSI-TA Review 7
  17Fri Feb 192:30 PMN315Protein – Small Molecule InteractionsMolecular basis of specificity, protein ligand interactions - structural basis of H-bonding, salt bridges and other interactionsPrasad, B V Venkatar
  18Mon Feb 222:30 PMN315Protein – Protein InteractionsStructural motifs that serve as protein-protein interaction domains, structural basis of surface complimentarity, engineering tight binding.Prasad, B V Venkatar
  19Wed Feb 242:30 PMN315Protein/DNA InteractionsDNA binding motifs, structural basis of base recognition, backbone interactionsPrasad, B V Venkatar
  8Thu Feb 255:15 PMN315MSI-TA Review 8
  20Fri Feb 262:30 PMN315Systems BiologySome principles and examples from systems biology approaches to understanding signaling in regulatory networksPedersen, Steen E
  1Tue Mar 011:15 PMN315Faculty Review
  1Wed Mar 021:15 PMN315MS Final Exam1:00-4:00
  
  
Term 4
  
  Course: GS-GS-519: Introduction to Scientific Writing
Course Director(s): Marriott, Susan Jean
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Mon Mar 142:30 PMN315Getting Prepared to WriteClass meets in N311Marriott, Susan Jean
  2Wed Mar 162:30 PMN315Parts of a Scientific Manuscript - IMarriott, Susan Jean
  3Mon Mar 212:30 PMN315Parts of a Scientific Manuscript - IIMarriott, Susan Jean
  4Wed Mar 232:30 PMN315Writing the First DraftMarriott, Susan Jean
  5Mon Mar 282:30 PMN315Striving for ClarityMarriott, Susan Jean
  6Wed Mar 302:30 PMN315Achieving Brevity through RevisionMarriott, Susan Jean
  7Mon Apr 042:30 PMN315Grammar for ScientistsMarriott, Susan Jean
  8Wed Apr 062:30 PMN315Submitting, Revising and Responding to ReviewsMarriott, Susan Jean
  
  Course: GS-GS-521: Introduction to Biostatistics
Course Director(s): Minard, Charles G.
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Mar 151:15 PMN315IntroductionPlease consult Blackboard for required text book and reading assignment prior to first class.Minard, Charles G.
  2Thu Mar 171:15 PMN315Summarizing DataMinard, Charles G.
  3Tue Mar 221:15 PMN315Probability distributionsMinard, Charles G.
  4Thu Mar 241:15 PMN315CLT and confidence intervalsMinard, Charles G.
  5Tue Mar 291:15 PMN315Hypothesis testing and comparing meansMinard, Charles G.
  6Thu Mar 311:15 PMN315Comparing proportions and sample sizeMinard, Charles G.
  7Tue Apr 051:15 PMN315Analysis of variance (ANOVA)Minard, Charles G.
  8Thu Apr 071:15 PMN315Multi-way ANOVAMinard, Charles G.
  9Tue Apr 121:15 PMN315Regression IMinard, Charles G.
  10Thu Apr 141:15 PMN315Regression IIMinard, Charles G.
  11Tue Apr 191:15 PMN315Regression IIIMinard, Charles G.
  12Thu Apr 211:15 PMN315Repeated measuresMinard, Charles G.
  13Tue Apr 261:15 PMN315Nonparametric methodsMinard, Charles G.
  14Thu Apr 281:15 PMN315Measures of associationSangi-Haghpeykar, Haleh
  15Tue May 031:15 PMN315Experimental designHilsenbeck, Susan G
  16Thu May 051:15 PMN315Experimental DesignMinard, Charles G.
  1Thu May 121:00 PMN311BS Final Exam1:00-4:00
  
  Course: GS-GS-522: Research Design
Course Director(s): Schmid, Michael F \ Schmid, Michael F
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Wed Mar 161:00 PMN311Research Design IntroductionThe application of the scientific method in proposing and designing research projects. The thought processes and methods used in grant applications and qualifying examinations. This class will meet in N311 at 1 PM.Schmid, Michael F
  2Wed Mar 231:00 PMN311Working Groups 1Project selection and design.Room assignments will be provided in the March 18 Introduction session.Zhou, Ming
  3Wed Mar 301:00 PMN311Working Groups 2Project selection and designPrasad, B V Venkatar
  4Wed Apr 061:00 PMN311Working Groups 3Project selection and designSokac, Anna Marie
  5Wed Apr 131:00 PMN311Working Groups 4Project selection and design
  6Wed Apr 201:00 PMN311Working Groups 5Project selection and design
  7Wed Apr 271:00 PMN311Working Groups 6
  8Wed May 041:00 PMN311Working Groups 7
  9Wed May 111:00 PMN311Research Design SymposiumA competitive, judged, symposium in which each of the student groups presents the design of their research project and answers questions about it.
  
  Course: GS-GS-525: Introduction to Intellectual Property
Course Director(s): Turley, C. Patrick
  No.DateStart TimeRoomLectureDescriptionLecturer
  1Tue Mar 229:00 AMN315Introduction & OverviewBrief introduction to law, including discussion of statutes, regulations, guidelines, and judicial interpretation(case law). Also included will be a brief discussion of the US Courts and how case law is made.Note: Classes will be held in N311.Turley, C. Patrick
  2Thu Mar 249:00 AMN315Patent OverviewWhat patents are and how to obtain a patent.Turley, C. Patrick
  3Tue Mar 299:00 AMN315Patents in DepthWhat can be patented, how to read and understand a patent.Discussion of cases involving patentablility of life forms and genes.Turley, C. Patrick
  4Thu Mar 319:00 AMN315Patent Infringement and International PatentingWhat constitutes infringement.How to obtain patents outside of the USA.Turley, C. Patrick
  5Tue Apr 059:00 AMN315Trademarks, Trade Secrets and AgreementsOverview of trademarks and trade secrets and how these differ from patents.Overview of the different types of intellectual property agreements you may encounter as an inventor.Turley, C. Patrick
  6Thu Apr 079:00 AMN315CopyrightsCopyright law, particularly with regard to course content and articles and other faculty publications.Turley, C. Patrick
  7Tue Apr 129:00 AMN315Exam ReviewReview of key concepts learned in class as applied to real-world situations.Turley, C. Patrick
  8Thu Apr 149:00 AMN315"Now what"Now that you have learned about intellectual property, what can you do with this information?Turley, C. Patrick

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