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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Martin M. Matzuk, M.D., Ph.D.

Martin M. Matzuk, M.D., Ph.D.

Professor and Stuart A. Wallace Chair
Department of Pathology and Immunology

Phone: 713-798-6451
Fax: 713-798-5838
E-mail: mmatzuk@bcm.edu

Education

  • M.D., Ph.D., Washington University, St. Louis, MO
  • Postdoctoral, Baylor College of Medicine, Houston, TX

Research Interests

  • Germ cell biology and oocyte-somatic cell interactions
  • MicroRNA pathways in reproduction and cancer
  • Transforming growth factor beta signaling pathways

Clinical Focus

  • Endometriosis
  • Infertility and Contraception
  • Ovarian Cancer

Selected Publications

  • Aitken JR, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJK. As the world grows: contraception in the 21st century. J Clin Invest. 2008. 118:1330-43.
  • Li Q, Graff JM, Connor AE, Loveland KL, Matzuk MM. SMAD3 regulates gonadal tumorigenesis. Mol Endocrin. 2007. 10:2472-86.
  • Lin YN, Roy A, Yan W, Burns KH, Matzuk MM. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol. 2007. 27:6794-805.
  • Greenbaum MP, Yan W, Wu MH, Lin YN, Agno JE, Sharma M, Braun RE, Rajkovic A, Matzuk MM. TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A. 2006. 103:4982-87.
  • Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet. 2006. 15:3411-19.
  • McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, Buster JE, Amato P, Matzuk MM. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod. 2004. 19:2869-74.
  • Wu X, Viveiros MM, Eppig JJ, Bai Y, Fitzpatrick SL, Matzuk MM. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet. 2003. 33:187-91.

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