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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Brett H. Graham, M.D., Ph.D.

Brett H. Graham, M.D., Ph.D.

Assistant Professor
Department of Molecular and Human Genetics

Phone: 713-798-6209
Fax: 713-798-4329


  • M.D., Ph.D. Emory University
  • Residency, Pediatrics, Baylor College of Medicine
  • Fellowship, Medical Genetics, Baylor College of Medicine

Research Interests

  • Genetic models of mitochondrial disorders in Drosophila and mouse
  • Mitochondrial biology
  • Energy metabolism

Clinical Focus

  • Inborn errors of metabolism
  • Human genetic disorders
  • Mitochondrial diseases

Selected Publications

  • Graham BH, Li Z, Alesii EP, Versteken P, Lee C, Wang J, Craigen WJ. Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease. J Biol Chem. 2010. 285(15):11143-53.
  • El-Hattab AW, Li FY, Shen J, Powell BR, Bawle EV, Adams DJ, Wahl E, Kobori JA, Graham B, Scaglia F, Wong LJ. Maternal systemic primary carnitine deficiency uncovered by newborn screening: clinical, biochemical, and molecular aspects. Genet Med. 2010. 12(1):19-24.
  • Wong LJ, Scaglia F, Graham BH, Craigen WJ. Current molecular diagnostic algorithm for mitochondrial disorders. Mol Genet Metab. 2010. 100(2):111-7.
  • Li L, Shen JJ, Bournat JC, Huang L, Chattopadhyay A, Li Z, Shaw C, Graham BH, Brown CW. Activin signaling: effects on body composition and mitochondrial energy metabolism. Endocrinology. 2009. 150(8):3521-9.
  • Wang J, Brautbar A, Chan AK, Dzwiniel T, Li FY, Waters PJ, Graham BH, Wong LJ. Two mtDNA mutations 14487T>C (M63V, ND6) and 12297T>C (tRNA Leu) in a Leigh syndrome family. Mol Genet Metab. 2009. 96(2):59-65.
  • Brautbar A, Wang J, Abdenur JE, Chang RC, Thomas JA, Grebe TA, Lim C, Weng SW, Graham BH, Wong LJ. The mitochondrial 13513G>A mutation is associated with Leigh disease phenotypes independent of complex I deficiency in muscle. Mol Genet Metab. 2008. 94(4):485-90.
  • Craigen WJ, Graham BH. Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions. J Bioenerg Biomembr. 2008. 40(3):207-12.

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