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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Jason Matthew Shohet, M.D., Ph.D.

Jason Matthew Shohet

Assistant Professor
Department of Pediatrics - Hematology and Oncology
Center for Cell and Gene Therapy

Phone: 832-824-4735
Fax: 832-825-4732
E-mail: jshohet@bcm.edu

Education

  • M.D., Ph.D., Boston University School of Medicine
  • Residency, Pediatrics, Baylor College of Medicine
  • Fellowship, Pediatric Hematology and Oncology, Baylor College of Medicine
  • Fellowship, Pediatric Hematology and Oncology, The University of Texas Southwestern Medical Center

Research Interests

  • Molecular biology of tumor cells

Selected Publications

  • Chen Z, Lin Y, Barbieri E, Burlingame S, Hicks J, Ludwig A, Shohet JM. Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo. Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo. Neoplasia. 2009. 11(8):753-62.
  • Slack AD, Chen Z, Ludwig AD, Hicks J, Shohet JM. MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells. Cancer Res. 2007. 67(6):2448-55.
  • Barbieri E, Mehta P, Chen Z, Zhang L, Slack A, Berg S, Shohet JM. MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death. Mol Cancer Ther. 2006. 5(9):2358-65.
  • Slack A, Lozano G, Shohet JM. MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis. Cancer Lett. 2005. 228(1-2):21-7.
  • Slack A, Shohet JM. MDM2 as a critical effector of the MYCN oncogene in tumorigenesis. Cell Cycle. 2005. 4(7):857-60.
  • Tonelli R, Purgato S, Camerin C, Fronza R, Bologna F, Alboresi S, Franzoni M, Corradini R, Sforza S, Faccini A, Shohet JM, Marchelli R, Pession A. Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis. Mol Cancer Ther. 2005. 4(5):779-86.
  • Vasudevan SA, Nuchtern JG, Shohet JM. Gene profiling of high risk neuroblastoma. World J Surg. 2005. 29(3):317-24.

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