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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Aaron E. Foster, Ph.D.

Aaron E. Foster, Ph.D.Assistant Professor
Department of Pediatrics - Hematology and Oncology
Center for Cell and Gene Therapy

Phone: 832-824-4734
Fax: 832-825-4732
E-mail: aaronf@bcm.edu

Education

  • Ph.D., University of Sydney
  • Postdoctoral Fellow, University of Sydney, Westmead Millennium Institute
  • Postdoctoral Fellow, Baylor College of Medicine, Center for Cell and Gene Therapy

Research Interests

  • Tumor biology and adoptive immunotherapy
  • Identification and characterization of tumor stem cells in neuroblastoma and lymphoma
  • Tumor vaccines

Selected Publications

  • Di Stasi A, De Angelis B, Rooney CM, Zhang L, Mahendravada A, Foster AE, Heslop HE, Brenner MK, Dotti G, Savoldo B. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood. 2009. 113(25):6392-402.
  • Foster AE, Leen AM, Lee T, Okamura T, Lu A, Vera J, Atkinson R, Dotti G, Rooney CM. Autologous designer antigen presenting cells by genetic modification of T lymphocyte blasts with IL-7 and IL-12. J Immunother. 2007. 30:506-16.
  • Leen AM, Ratnayake M, Foster AE, Rooney CM, Gottschalk S. Contact activated Monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cells. J Immunother. 2007. 30:96-107.
  • Leen AM, Rooney CM, Foster AE. Improving T cell therapy for cancer. Annu Rev Immunol. 2007. 25:243-65.
  • Quintarelli C, Vera JF, Savoldo B, Giordano Attianese GM, Pule M, Foster AE, Heslop HE, Rooney CM, Brenner MK, Dotti G. Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood. 2007.110:2793-802.
  • Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE, Zhang L, Heslop HE, Brenner MK, Dotti G. Epstein barr virus-specific cytotoxic T lymphocytes expressing the anti-CD30{zeta} artificial chimeric T-cell receptor for immunotherapy of Hodgkin's disease. Blood. 2007. 110:2620-30.

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