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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Huda Y. Zoghbi, M.D.

Huda Y. Zoghbi

Professor
Department of Molecular and Human Genetics

Phone: 713-798-6558
Fax: 713-798-8728
E-mail: hzoghbi@bcm.edu

Education

  • M.D., American University of Beirut/Meharry Medical College
  • Postdoctoral, Baylor College of Medicine, Houston, TX

Research Interests

  • Pathogenesis of neurodegenerative diseases such as ataxias
  • Rett syndrome
  • MECP2 duplication disorders
  • Autism
  • Cerebellar and brain stem development
  • Mouse models

Clinical Focus

  • Rett syndrome and related disorders
  • Inherited ataxias

Selected Publications

  • Flora A, Klisch TJ, Schuster G, Zoghbi HY. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science. 2009. 326(5958):1424-7.
  • Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009. 64(3):341-54. (This paper was reviewed by Faculty of 1000 Biology.)
  • Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY. MeCP2, a key contributor to neurological disease, activates and represses transcription. Science. 2008. 320(5880):1224-9. (This paper was the subject of a Science commentary by Cohen S, Zhou Z, Greenberg ME, May 30; 320(5880):1172-3.)
  • Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008. 452(7188):713-8. (This paper was the subject of a Nature News & Views commentary by Thompson L, Apr 10; 452(7188):707-8.)
  • Bowman AB, Lam YC, Jafar-Nejad P, Chen H-K, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Nat Genet. 2007. 39:373-9.
  • Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY. Mutant ataxin-1 interacts with the transcriptional repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. 2006. 127:1335-47.
  • McGill B, Bundle SF, Yaylaoglu, MB, Carson JP, Thaller C and Zoghbi HY. Enhanced anxiety and stress in a mouse model of Rett syndrome are linked to the regulation of Crh by MeCP2. PNAS. 2005. 103:18267-72.

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