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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Lynn Zechiedrich, Ph.D.

E. Lynn Zechiedrich

Associate Professor
Department of Molecular Virology and Microbiology

Phone: 713-798-5126
Fax: 713-798-7375
E-mail: elz@bcm.edu
Lab Web Site: Zechiedrich Lab

Education

  • Ph.D., Vanderbilt University
  • Postdoctoral, University of California, Berkeley

Research Interests

  • Drug resistance
  • Genetic alterations
  • DNA topoisomerase function

Selected Publications

  • Zechiedrich L, Osheroff N. Topoisomerase IB-DNA interactions: X marks the spot. Structure. 2010. 18(6):661-3.
  • Becnel Boyd L, Maynard MJ, Morgan-Linnell SK, Horton LB, Sucgang R, Hamill RJ, Jimenez JR, Versalovic J, Steffen D, Zechiedrich L. Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009. 53(1):229-34.
  • Morgan-Linnell SK, Becnel Boyd L, Steffen D, Zechiedrich L. Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009. 53(1):235-41.
  • Randall GL, Zechiedrich L, Pettitt BM. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form. Nucleic Acids Res. 2009. 37(16):5568-77.
  • Boyd LB, Atmar RL, Randall GL, Hamill RJ, Steffen D, Zechiedrich L. Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location. BMC Infect Dis. 2008. 8:4.
  • Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. Assessing sensitivity to antibacterial topoisomerase II inhibitors. Curr Protoc Pharmacol. 2007. 39:3.13.1-3.13.26.
  • Morgan-Linnell SK, Zechiedrich L. Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother. 2007. 51(11):4205-8.

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