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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Jianhua Yang, Ph.D.

Jianhua Yang

Assistant Professor
Department of Pediatrics - Hematology and Oncology

Phone: 832-824-4572
Fax: 832-824-4539
E-mail: jianhuay@bcm.edu

Education

  • Ph.D, University of Texas-Houston, Houston, TX
  • Postdoctoral Fellowship, Baylor College of Medicine, Houston, TX

Research Interests

  • Molecular targets in cancer, protein kinase and phosphatase, protein ubiquitination and deubiquitination

Selected Publications

  • Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Zhang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010. 285(8):5347-60.
  • Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM, Donehower LA, Nuchtern JG, Yang J. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010 Jun 21. [Epub ahead of print]
  • Sun W, Ge N, Yu Y, Burlingame S, Li X, Zhang M, Ye S, Fu S, Yang J. Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. J Biol Chem. 2010. 285(11):7911-8.
  • Sun W, Tan X, Shi Y, Xu G, Mao R, Gu X, Fan Y, Yu Y, Burlingame S, Zhang H, Rednam SP, Lu X, Zhang T, Fu S, Cao G, Qin J, Yang J. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. Cell Signal. 2010. 22(3):386-94.
  • Sun W, Wang H, Zhao X, Yu Y, Fan Y, Wang H, Wang X, Lu X, Zhang G, Fu S, Yang J. Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. J Biol Chem. 2010. 285(28):21341-8.
  • Sun W, Yang J. Molecular basis of lysophosphatidic acid-induced NF-kappaB activation. Cell Signal. 2010 May 12. [Epub ahead of print]
  • Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J. Ubiquitin specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem. 2010. 285:969-78.

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