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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Nancy L. Weigel, Ph.D.

Nancy L. Weigel

Professor
Department of Molecular and Cellular Biology

Phone: 713-798-6234
Fax: 713-790-1275
E-mail: nweigel@bcm.edu

Education

  • Ph.D., Johns Hopkins University, Baltimore, MD
  • Postdoctoral, Baylor College of Medicine, Houston, TX

Research Interests

  • Coactivators and androgen receptors in prostate cancer
  • Vitamin D receptor target genes

Selected Publications

  • Washington MN, Kim JS, Weigel NL. 1alpha,25-dihydroxyvitamin D(3) inhibits C4-2 prostate cancer cell growth via a retinoblastoma protein (Rb)-independent G(1) arrest. Prostate. 2010 Jul 14. [Epub ahead of print]
  • Washington MN, Weigel NL. 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion. Endocrinology. 2010. 151(4):1409-17.
  • Agoulnik IU, Weigel NL. Coactivator selective regulation of androgen receptor activity. Steroids. 2009. 74(8):669-74.
  • Rohan JN, Weigel NL. 1Alpha,25-dihydroxyvitamin D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells. Endocrinology. 2009. 150(5):2046-54.
  • Agoulnik IU, Bingman WE 3rd, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL. Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase. Mol Endocrinol. 2008. 22(11):2420-32.
  • Weigel NL, Moore NL. Kinases and protein phosphorylation as regulators of steroid hormone action. Nucl Recept Signal. 2007. 5:e005.
  • Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman WE 3rd, Erdem H, Frolov A, Smith CL, Ayala GE, Ittmann MM, Weigel NL. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res. 2006. 66(21):10594-602.

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