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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Xander H.T. Wehrens, M.D., Ph.D.

Xander H.T. Wehrens

Professor
Department of Molecular Physiology and Biophysics
Department of Medicine - Cardiology
Juanita P. Quigley Endowed Chair in Cardiology

Phone: 713-798-4261
Fax: 713-798-3475
E-mail: wehrens@bcm.edu

Education

  • M.D./Ph.D., Maastricht University, the Netherlands
  • Postdoctoral, Columbia University, New York

Research Interests

  • Molecular mechanisms and mouse models of cardiac arrhythmias and heart failure
  • Intracellular calcium homeostasis
  • New drug development

Clinical Focus

  • Electrophysiology
  • Heart failure

Selected Publications

  • Jeyaraj D, Halder SM, Wan X, McCauley MD, Lu Y, Eapen B, Ripperger JA, Albrecht U, Sharma N, Cutler M, Gulick J, Sanbe A, Robbins J, Wehrens XH, Rosenbaum DS, Jain MK. Circadian Clock regulates cardiac repolarization and susceptibility to arrhythmias. Nature; in press.
  • Li N, Wang T, Wang W, Culter MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XHT. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knock-out mice. Circ Res. 2012; 110(3): 465-70.
  • van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 8;123(9):979-88
  • Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar;4(2):214-23. Epub 2011 Jan 7.
  • McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun;32(6):749-57.
  • van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 8;123(9):979-88.
  • Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar 1;4(2):214-23.
  • van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure. Circulation. 2010 Dec 21;122(25):2669-79.
  • Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2010 Nov 3.
  • Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2010 Sep 29.
    Garbino A, Wehrens XH. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep;31(9):1019-21.

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