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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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David J. Tweardy, M.D.

David J. Tweardy

Department of Medicine - Infectious Diseases

Phone: 713-798-8918 or 713-798-8908
Fax: 713-798-8948


  • M.D., Harvard Medical School, Boston, MA
  • Residency, Internal Medicine, Case Western Reserve University School of Medicine, Cleveland, OH
  • Fellowship, Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH

Research Interests

  • Innate immunity
  • Signal transducer and activator of transcription (STAT) protein structure and function focusing on Stat3

Clinical Focus

  • Nosocomial infections especially pneumonias

Selected Publications

  • Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol. 2010. 2010:597086.
  • Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010. 115(3):643-52.
  • Kasembeli MM, Xu X, Tweardy DJ. SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci. 2009. 14:1010-22.
  • Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci. 2009. 2(1):41-9.
  • Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med. 2009. 2(1):76-86.
  • Tweardy DJ, Belmont JW. "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. Transl Res. 2009. 154(6):288-94.
  • Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One. 2009. 4(3):e4783

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