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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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David Sheikh-Hamad, M.D., F.A.H.A., F.A.S.N.

David Shiekh-Hamad

Professor
Department of Medicine - Nephrology
Department of Molecular and Cellular Biology
Chief of Renal Services at Ben Taub Hospital

Phone: 713-798-1301
Fax: 713-798-5010
Email: sheikh@bcm.edu

Education

  • M.D., Hadassah Medical School, Jerusalem, Israel
  • Residency, Internal Medicine, University of California, Los Angeles, San Fernando Valley Program
  • Fellowship, Clinical Nephrology, University of California, Los Angeles
  • Fellowship, Molecular Mechanisms of the Adaptive Response of Kidney Cells to Osmotic Stress, Lab of Kidney and Electrolytes Mechanisms, National Institutes of Health

Research Interests

  • Stanniocalcin-1
  • Regulation of mitochondrial superoxide
  • Inflammation and kidney injury
  • Adaptation to osmotic stress
  • Cardiac failure: mechanisms

Clinical Focus

  • General nephrology
  • Toxic nephropathy
  • CKD and cardiovascular disease
  • Dysnatremias; salt and water homeostasis

Selected Publications

  • Huang L, Garcia G, Lou Y, Zhou Q, Truong LD, DiMattia G, Lan XR, Lan HY, Wang Y, Sheikh-Hamad D. Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis. Am J Pathol. 2009. 174(4):1368-78.
  • Wang Y, Huang L, Abdelrahim M, Cai Q, Truong A, Bick R, Poindexter B, Sheikh-Hamad D. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. J Leukoc Biol. 2009. 86(4):981-8.
  • Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008. 28(5):906-12.
  • Chakraborty A, Brooks H, Zhang P, Smith W, McReynolds MR, Hoying JB, Bick R, Truong L, Poindexter B, Lan H, Elbjeirami W, Sheikh-Hamad D. Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes. Am J Physiol Renal Physiol. 2007. 292(2):F895-904.
  • Padda R, Wamsley-Davis A, Gustin MC, Ross R, Yu C, Sheikh-Hamad D. MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells. Am J Physiol Renal Physiol. 2006. 291(4):F874-81.
  • Kanellis J, Bick R, Garcia G, Truong L, Tsao CC, Etemadmoghadam D, Poindexter B, Feng L, Johnson RJ, Sheikh-Hamad D. Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis. Am J Physiol Renal Physiol. 2004. 286(2):F356-62.
  • Wamsley-Davis A, Padda R, Truong LD, Tsao CC, Zhang P, Sheikh-Hamad D. AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan. Am J Physiol Renal Physiol. 2004. 287(3):F474-80.

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