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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Cliona M. Rooney, Ph.D.

Cliona M. Rooney

Professor
Department of Pediatrics - Hematology and Oncology
Department of Pathology and Immunology
Center for Cell and Gene Therapy
Texas Children's Cancer Center

Phone: 832-824-4693
Fax: 832-825-4732
E-mail: crooney@bcm.edu

Education

  • Ph.D., Immunology, University of Cambridge, England
  • Postdoctoral Fellow, Universities of Bristol and Birmingham, England
  • Postdoctoral Fellow, Yale University, New Haven, CT

Research Interests

  • Immunotherapy
  • Cytotoxic T cells
  • Gene therapy

Selected Publications

  • Foster AE, Leen AM, Lee T, Okamura T, Lu A, Vera J, Atkinson R, Dotti G, Rooney CM. Autologous designer antigen presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12. J.Immunotherapy. 2007. 30(5):506-16.
  • Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, Carrum G, Krance RA, Chang C-C, Molldrem JJ, Gee AP, Brenner MK, Heslop HE, Rooney CM, Bollard CM. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006. 12(10):1160-1166.
  • Straathof KC, Pulè MA, Yotnda P, Dotti G, Vanin EF, Brenner MK, Heslop HE, Spencer DM, Rooney CM. An Inducible Caspase 9 Safety Switch For T Cell Therapy. Blood. 2005. 105:4247-4254.
  • Bollard CM, Straathof KC, Huls MH, Leen A, Lacuesta K, Davis A, Gottschalk S, Brenner MK, Heslop HE, Rooney CM. The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease. J Immunother. 2004. 27(4):317-27.
  • Bollard CM, Rossig C, Calonge MJ, Huls MH, Wagner HJ, Massague J, Brenner MK, Heslop HE, Rooney CM. Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood. 2002. 99:3179-87.
  • Savoldo B, Huls MH, Liu Z, Volk HD, Reinke P, Sabat R, Babel N, Jones JF, Webster-Cyriaque J, Gee AP, Brenner MK, Heslop HE, Rooney CM. Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood. 2002. 100:4059-66.
  • Gottschalk S, NG C, Perez M, Smith CA, Sample C, Brenner MK, Heslop HE, Rooney CM. An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsible to therapy with virus-specific CTLs. Blood. 2001. 97:835-43.

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