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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Yi Li, Ph.D.

Yi Li

Assistant Professor
Department of Molecular and Cellular Biology
Smith Breast Center

Phone: 713- 798-3963
Fax: 713-798-1673
Lab Web Site: Yi Li Lab


  • Ph.D., Department of Microbiology, Michigan State University, East Lansing, MI
  • Postdoctoral Fellow, Department of Biochemistry, Michigan State University, East Lansing, MI
  • Postdoctoral Fellow, National Cancer Institute, NIH, Bethesda, MD
  • Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, New York, NY

Research Interests

  • Stem cells and breast cancer
  • Wnt signaling and cell fate

Selected Publications

  • Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li Y. Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis in the absence of reproductive hormones. Dev Biol. In press.
  • Tonef M., Du Z, Sinai P, Forman J, Huang J, Hilsenbeck S, Schiff R, Huan S, Li Y. Somatic activation of PyMT or ErbB2 induces estrogen-independent tumor initiation. Neoplasia. In press.
  • Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A. 2010. 107(8):3728-33.
  • Du Z, Podsypanina K, Huang H, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck MM, Allred DC, Lewis MT, Varmus HE, Li Y. Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A. 2006. 103:17396-401.
  • Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006. 281:35081-7.
  • Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE and Varmus HE. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biology. 2005. 6:R84.
  • Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li Y. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene. 2005. 24:4220-31.

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