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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Brendan Lee, M.D., Ph.D.

Brendan Lee, M.D., Ph.D.

Department of Molecular and Human Genetics
Director of Texas Children's Skeletal Dysplasia Clinic

Phone: 713-798-8835
Fax: 713-798-5168


  • M.D., Ph.D., State University of New York Health Science Center, Brooklyn, NY
  • Postdoctoral Fellow, Mount Sinai School of Medicine
  • Residency, Pediatrics, Baylor College of Medicine, Houston, TX
  • Fellow, Medical Genetics, Baylor College of Medicine, Houston, TX

Research Interests

  • Genetic pathways that specify development and homeostasis
  • Translational studies of skeletal development
  • Therapy for metabolic diseases

Clinical Focus

  • Cell and gene therapy

Selected Publications

  • Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010. 120(7):2474-85.
  • Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med. 2008. 14(3):299-305.
  • Morello R, Bertin T, Chen Y, Hicks J, Tonachini L, Monticone M, Castagnola P, Rauch F, Glorieux FH, Vranka J, Bächinger HP, Schwarze U, Byers PH, Weis MA, Fernandes RJ, Eyre DR, Yao Z, Boyce BF, Lee B. CRTAP is required for 3-prolyl-hydroxylation and loss of its function causes recessive Osteogenesis Imperfecta. Cell. 2006. 127:291-304.
  • Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B. Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A. 2006. 103:19004-9.
  • Toietta G, Mane V, Norona WS, Finegold MJ, Ng P, McDonagh AF, Beaudet AL, Lee B. Complete, long-term correction of hyperbilirubinemia in the Gunn rat. Proc Natl Acad Sci U S A. 2005. 102:3930-5.
  • Zheng Q, Zhou G, Morello R, Chen Y, Garcia-Rojas X, Lee B. Type X collagen gene regulation by Runx2 contributes to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol. 2003. 162:833-42.
  • Miner JH, Morello R, Li C, Andrews KL, Antignac C, Shaw AS, Lee B. A role for Lmx1b in podocyte development and function as a transcriptional regulator of Cd2ap and Nphs2 (podocin). J Clin Invest. 2002. 109:1065-72.

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