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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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H. Daniel Lacorazza, Ph.D.

H. Daniel Lacorazza

Assistant Professor
Department of Pathology and Immunology

Phone: 832-824-5103
Fax: 832-825-1032
E-mail: hdl@bcm.edu

Education

  • Ph.D., School of Biochemistry, University of Buenos Aires, Argentina
  • Visiting Fellow, National Institutes of Health (NEI/LI), Bethesda, MD
  • Research Fellow, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY

Research Interests

  • Developmental immunology and hematopoiesis
  • Transcription factor ELF-4
  • Stem cell maintenance

Selected Publications

  • Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer S. The transcription factor MEF (ELF4) regulates the quiescence of primitive hematopoietic cells. Cancer Cell. 2006. 9:175-87.
  • Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTα in T lymphocyte development. Nature Immunology. 2002. 3:483-8.
  • Lacorazza HD, Miyazaki Y, Di Cristofano A, Deblasio T, Hedvat C, Cordon-Cardo C, Mao S, Zhang J, Pandolfi PP, Nimer SD. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer vells and NK-T cells. Immunity. 2002. 17:437-49.
  • Lacorazza HD, Porritt H, Nikolic-Zugic J. Dysregulated expression of pre-Tα reveals the opposite effects of pre-TCR at successive stages of T cell development. Journal of Immunology. 2001. 167:5689-96.
  • Lacorazza HD, Tucek C, Vasovic L, Remus K, Nikolic-Zugic J. Premature TCRαβ expression and signaling in pre-thymocytes impair thymocyte expansion and partially block their development. Journal of Immunology. 2001. 166:3184-93.
  • Lacorazza HD, Flax J, Snyder E, Jendoubi M. Expression of human β-hexosaminidase α-subunit gene in mouse brains upon engraftment of transduced progenitor cells. Nature Medicine. 1996. 2:424-9.

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