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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Saul J. Karpen, M.D., Ph.D.

Saul J. Karpen

Professor
Department of Pediatrics - Gastroenterology,
Hepatology and Nutrition
Director of Texas Children's Liver Center

Phone: 832-824-3754
Fax: 832-825-4893
E-mail: skarpen@bcm.edu

Education

  • Ph.D., Mount Sinai School of Medicine
  • M.D., Mount Sinai School of Medicine
  • Residency, Pediatrics, Yale University
  • Fellowship, Gastroenterology/Hepatology, Yale University

Research Interests

  • Molecular mechanisms of cholestasis
  • Nuclear receptors
  • Hepatobiliary transporter genes

Selected Publications

  • Balistreri WF, Bezerra JA, Jansen P, Karpen SJ, Shneider BL, Suchy FJ. Intrahepatic cholestasis: summary of an American Association for the Study of Liver Diseases single-topic conference. Hepatology. 2005. 42(1):222-35.
  • Karpen SJ. Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. Hepatology. 2005. 42(2):266-9.
  • Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid nuclear export of hepatic RXRa. Nucl Recept. 2004. 2:4.
  • Kurbegov A, Karpen SJ. Bile formation and cholestasis. In: W.A Walker, O.L. Goulet, R.E. Kleinman, I.R. Sanderson, P.M. Sherman, B.L. Shneider, eds. Pediatric Gastrointestinal Disease, 4th Edition. Ontario: BC Decker, Inc., 2004, pp. 70-9.
  • Karpen SJ. Transcriptional regulation of hepatobiliary transporters. In: M. Trauner and P. Jansen, eds. Molecular Pathogenesis of Cholestasis. Georgetown, TX: Eurekah.com/Landes Bioscience and Kluwer Academic/Plenum Publishers, 2004, pp. 96-111.
  • Horst D, Karpen SJ. Bile formation and cholestasis. In: R.A. Polin, W.W. Fox, and S.H. Abman, eds. Fetal and Neonatal Physiology, 3rd Edition. Philadelphia: Saunders, 2003, pp. 1186-98.

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