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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Helen E. Heslop, M.D.

Helen E. Heslop

Professor
Department of Medicine
Department of Pediatrics - Hematology and Oncology
Center for Cell and Gene Therapy
Director of Adult Stem Cell Transplant Program

Phone: 832-824-4662
Fax: 832-825-4668
E-mail: hheslop@bcm.edu

Education

  • M.D., Otago University Medical School, New Zealand
  • Fellowship, Department of Haematology, Royal Free Hospital, London, England

Research Interests

  • Adoptive immunotherapy
  • Lymphoproliferative disorders

Clinical Focus

  • Hemopoietic stem cell transplantation
  • Lymphoma

Selected Publications

  • Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels W, Bhattacharjee MB, Gilbertson RJ, Shine DH, Weiss HL, Rooney CM, Heslop HE, Gottschalk SM. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007. 67:5957-64.
  • Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, Khalil M, Wu MF, Huls MH, Chang CC, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE. Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 2007. 110(8):2838-45.
  • Leen A, Myers GD, Sili U, Huls MH, Leung K, Carrum G, Krance RA, Weiss H, Gee AP, Brenner MK, Heslop HE, Rooney CM, Bollard CM. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised patients. Nat Med. 2006. 12:1160-6.
  • Savoldo B, Goss JA, Hammer M, Zhang L, Lopez T, Gee AP, Lin Y-F, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold M, Brenner MK, Rooney CM, Heslop HE. Autologous Epstein Barr virus-specific cytotoxic T lymphocyte (CTL) infusions for solid organ transplant recipients. Blood. 2006. 108:2942-9.
  • Straathof KC, Bollard CM, Popat U, Huls MH, Lopez T, Morriss MC, Gresik MV, Gee AP, Russell HV, Brenner MK, Rooney CM, Heslop HE. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes. Blood. 2005. 105:1898-904.
  • Bollard CM, Aguilar L, Straathof KC, Gahn B, Huls MH, Rousseau A, Sixbey J, Gresik MV, Carrum G, Hudson M, Dilloo D, Gee AP, Brenner MK, Rooney CM, Heslop HE. Cytotoxic T lymphocyte therapy for EBV-positive Hodgkin's disease. J Exp Med. 2004. 200:1623-33.
  • Wagner HJ, Cheng YC, Huls MH, Gee AP, Kuehnle I, Krance RA, Brenner MK, Rooney CM, Heslop HE. Prompt versus pre-emptive Intervention for EBV- lymphoproliferative disease. Blood. 2004. 103:3979-81.

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