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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Susan L. Hamilton, Ph.D.

Susan L. Hamilton

Professor and Chair
Department of Molecular Physiology and Biophysics

Phone: 713-798-5704
Fax: 713-798-5441


  • Ph.D., University of Colorado Medical Center
  • Postdoctoral, Columbia University

Research Interests

  • Molecular mechanisms of ryandoine receptor mutations
  • Malignant hypertheria
  • Congenital arrhythmias

Selected Publications

  • Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J. 2006. 20(2):329-30.
  • Kannankeril PJ, Goonasekera SA, Mitchell BM, Chelu MG, Zhang W, Kearney DK, De Biasi M, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and mild cardiomyopathy. Proc Natl Acad Sci U S A. 2006. 10332:12179-84.
  • Xiong LW, Zhang JZ, He R, Hamilton SL. A Ca2+ binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity. Biophysical J. 2006. 901:173-82.
  • Fallon JL, Halling DB, Hamilton SL, Quiocho FA. Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Cav1.2 calcium channel. Structure. 2005 131:1881-6.
  • Halling DB, Aracena-Parks P, Hamilton SL. Regulation of voltage gated Ca2+ channels by calmodulin. Science STKE. 2005. 315:re15.
  • Hamilton SL. Ryanodine receptors. Cell Calcium. 2005. 38:253-60.
  • Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. The pore structure of the closed RyR1 channel. Structure. 2005. 13:1203-11.

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