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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Xinfu Guan, Ph.D.

Xinfu Guan

Assistant Professor
Children's Nutrition Research Center
Department of Pediatrics - Nutrition
Department of Medicine - Diabetes, Endocrinology and Metabolism

Phone: 713-798-9322
Fax: 713-798-7101
E-mail: xguan@bcm.edu

Education

  • Ph.D., Nutrition and Physiology, Michigan State University
  • Postdoctoral Fellowship, Gastroenterology and Nutrition, Baylor College of Medicine

Research Interests

  • Cellular action and signaling network of glucagon-like peptide receptors (GLP-1R and GLP-2R)

Selected Publications

  • Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010. 298(2):E156-66.
  • Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism. 2010. 59(7):967-76.
  • Burrin DG, Stoll B, Guan X, Cui L, Chang X, Hadsell D. GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets. Am J Physiol Endocrinol Metab. 2007. 292(1):E281-91.
  • Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006. 130(1):150-64.
  • Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Burrin DG, Tomé D. Postprandial intestinal and whole body nitrogen kinetics and distribution in piglets fed a single meal. Am J Physiol Endocrinol Metab. 2005. 288(2):E436-46.
  • Burrin DG, Stoll B, Guan X, Cui L, Chang X, Holst JJ. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets. Endocrinology. 2005. 146(1):22-32.
  • Guan X, Stoll B, Lu X, Tappenden KA, Holst JJ, Hartmann B, Burrin DG. GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1. Gastroenterology. 2003. 125(1):136-47.

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