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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Stephen M. Gottschalk, M.D.

Stephen M. Gottschalk

Associate Professor
Department of Pediatrics - Hematology and Oncology
Department of Pathology and Immunology
Center for Cell and Gene Therapy

Phone: 832-824-4179
Fax: 832-825-4732
E-mail: smg@bcm.edu

Education

  • M.D., Medical School, University of Göttingen, Germany
  • Research Fellowship, Cell Biology, Baylor College of Medicine, Houston, TX
  • Residency, Pediatrics, Baylor College of Medicine, Houston, TX
  • Postdoctoral Fellowship, Pediatric Hematology and Oncology, Texas Children's Cancer Center and Hematology Service, Texas Children's Hospital and Baylor College of Medicine, Houston, TX

Research Interests

  • Immunotherapy for malignancies including brain tumors, lung cancer, nasopharyngeal carcinoma, and sarcomas
  • Immunotherapy for viral associated diseases

Clinical Focus

  • Stem cell transplantation
  • Epstein Barr virus associated diseases

Selected Publications

  • Ahmed N, Salsman VS, Kew Y, Shaffer D, Powell S, Zhang YJ, Grossman RG, Heslop HE, Gottschalk S. HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors. Clin Cancer Res. 2010. 16(2):474-85.
  • Ahmed N, Salsman VS, Yvon E, Louis CU, Perlaky L, Wels WS, Dishop MK, Kleinerman EE, Pule M, Rooney CM, Heslop HE, Gottschalk S. Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol Ther. 2009. 17(10):1779-87.
  • Louis CU, Straathof K, Bollard CM, Gerken C, Huls MH, Gresik MV, Wu MF, Weiss HL, Gee AP, Brenner MK, Rooney CM, Heslop HE, Gottschalk S. Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood. 2009. 113(11):2442-50.
  • Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007. 67(12):5957-64.
  • Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, Khalil M, Wu MF, Huls MH, Chang CC, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE. Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 2007. 110(8):2838-45.
  • Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE. Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood. 2006. 108(9):2942-9.
  • Gottschalk S, Rooney CM, Heslop HE. Post-transplant lymphoproliferative disorders. Annu Rev Med. 2005. 56:29-44.

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