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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Margaret A. Goodell, Ph.D.

Margaret A. GoodellProfessor
Department of Pediatrics - Hematology and Oncology
Center for Cell and Gene Therapy
Director of Stem Cells and Regenerative Medicine Center

Phone: 713-798-1265
Fax: 713-798-1230
Lab Web Site: Goodell Laboratory


  • Ph.D., University of Cambridge, England
  • Postdoctoral, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
  • Postdoctoral, Harvard Medical School

Research Interest

  • Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development

Selected Publications

  • Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010. 465(7299):793-7.
  • Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010. 6(3):265-78.
  • Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MA. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008. 2(1):83-9.
  • Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007. 5(8):e201.

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