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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Xin-Hua Feng, Ph.D.

Xin-Huag Feng

Professor
Department of Molecular and Cellular Biology
Department of Surgery - General Surgery

Phone: 713-798-4756
Fax: 713-798-4093
E-mail: xfeng@bcm.edu

Education

  • Ph.D., University of Maryland, College Park
  • Postdoctoral, University of California, San Francisco

Research Interests

  • Proteins modifications and signaling mechanisms in cell growth control
  • Tissue differentiation and tumorigenesis
  • TGFß/SMAD signaling and human diseases
  • Protein phosphatases
  • Ubiquitination, sumoylation and proteasome-dependent degradation

Selected Publications

  • Dai F, Lin X, Chang C, Feng X-H. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-ß signaling. Dev Cell. 2009. 16:345-57.
  • Wrighton K, Lin X, Feng X-H. Critical role of chaperone HSP90 in TGF-ß signaling. Proc Natl Acad Sci U S A. 2008. 105:9244-49.
  • Dai F, Chang C, Lin X, Dai G, Mei L, Feng X-H. Erbin inhibits TGF-ß signaling through a novel Smad-interacting domain. Mol Cell Biol. 2007. 27:6183-94.
  • Wang D, Long J, Dai F, Liang M, Feng X-H, Lin X. Bcl6 represses Smad signaling in TGF-ß resistance. Cancer Res. 2007. 68:783-9.
  • Lin X, Duan X, Liang Y, Su Y, Wrighton K, Hu M, Long J, Davis C, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng X-H. PPM1A functions a Smad phosphatase to terminate TGF-ß signaling. Cell. 2006. 125:915-28.
  • Wrighton K, Willis D, Long J, Liu F, Lin X, Feng X-H. Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-ß signaling. J Biol Chem. 2006. 281:38365–75.
  • Feng X-H, Derynck R. Specificity and versatility of TGF-ß signaling through Smads. Ann Rev Cell Dev Biol. 2005. 12:659-93.

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