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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Lawrence A. Donehower, Ph.D.

Lawrence A. Donehower

Department of Molecular Virology and Microbiology

Phone: 713-798-3594
Fax: 713-798-3490


  • Ph.D., George Washington University
  • Postdoctoral, University of California, San Francisco

Research Interests

  • p53 in cancer and aging
  • Genetic alterations in osteosarcomas
  • Wip1 function and chemotherapy

Selected Publications

  • Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA. Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem. 2010. 285:12935-47.
  • Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nature Rev Cancer. 2009. 9:831-41.
  • Hinkal G, Parikh N, Donehower LA. Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression. PLoS One. 2009. 4:e6654.
  • Lu X, Nguyen TA, Moon SH, Darlington Y, Sommer M, Donehower LA. The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev. 2008. 27:123-35.
  • Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007. 12:342-54.
  • Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes & Dev. 2005. 19:1162-74.
  • Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002. 415:45-53.

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